Search Results - "Pluta, Ryszard M"

The importance of early brain injury after subarachnoid hemorrhage by Sehba, Fatima A, Hou, Jack, Pluta, Ryszard M, Zhang, John H

“…Aneurysmal subarachnoid hemorrhage (aSAH) is a medical emergency that accounts for 5% of all stroke cases. Individuals affected are typically in the prime of…”
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Metamorphosis of Subarachnoid Hemorrhage Research: from Delayed Vasospasm to Early Brain Injury by Sehba, Fatima A, Pluta, Ryszard M, Zhang, John H

“…Delayed vasospasm that develops 3-7 days after aneurysmal subarachnoid hemorrhage (SAH) has traditionally been considered the most important determinant of…”
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Cerebral vasospasm following subarachnoid hemorrhage: time for a new world of thought by Pluta, Ryszard M., Hansen-Schwartz, Jacob, Dreier, Jens, Vajkoczy, Peter, Macdonald, R. Loch, Nishizawa, Shigeru, Kasuya, Hideotoshi, Wellman, George, Keller, Emanuela, Zauner, Alois, Dorsch, Nicholas, Clark, Joseph, Ono, Shigeki, Kiris, Talat, LeRoux, Peter, Zhang, John H.

“…Objective: Delayed cerebral vasospasm has long been recognized as an important cause of poor outcome after an otherwise successful treatment of a ruptured…”
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Safety and feasibility of long-term intravenous sodium nitrite infusion in healthy volunteers by Pluta, Ryszard M, Oldfield, Edward H, Bakhtian, Kamran D, Fathi, Ali Reza, Smith, René K, Devroom, Hetty L, Nahavandi, Masoud, Woo, Sukyung, Figg, William D, Lonser, Russell R

“…Infusion of sodium nitrite could provide sustained therapeutic concentrations of nitric oxide (NO) for the treatment of a variety of vascular disorders. The…”
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To Be-et, or Not to Be-et, That is the Question: The Role(s) of Nitrate and Nitrite in Health and Illness by Pluta, Ryszard M

“…This manuscript addresses the multilevel role of dietary nitrate and nitrite in health and diseases because of increased interest in dietary supplementation…”
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Dysfunction of nitric oxide synthases as a cause and therapeutic target in delayed cerebral vasospasm after SAH by Pluta, Ryszard M.

“…Nitric oxide (NO), also known as endothelium-derived relaxing factor, is produced by endothelial nitric oxide synthase (eNOS) in the intima and by neuronal…”
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Aneurysmal Subarachnoid Hemorrhage Models: Do They Need a Fix? by Sehba, Fatima A., Pluta, Ryszard M.

“…The discovery of tissue plasminogen activator to treat acute stroke is a success story of research on preventing brain injury following transient cerebral…”
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The role of nitric oxide donors in treating cerebral vasospasm after subarachnoid hemorrhage by Fathi, Ali R, Bakhtian, Kamran D, Pluta, Ryszard M

“…Reduced intra- and perivascular availability of nitric oxide (NO) significantly contributes to the multifactorial pathophysiology of cerebral vasospasm after…”
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Validation of Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Derived Vascular Permeability Measurements Using Quantitative Autoradiography in the RG2 Rat Brain Tumor Model by Ferrier, Moira C., Sarin, Hemant, Fung, Steve H., Schatlo, Bawarjan, Pluta, Ryszard M., Gupta, Sandeep N., Choyke, Peter L., Oldfield, Edward H., Thomasson, David, Butman, John A.

“…Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is widely used to evaluate tumor permeability, yet measurements have not been directly validated…”
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Association between cerebrospinal fluid levels of asymmetric dimethyl-L-arginine, an endogenous inhibitor of endothelial nitric oxide synthase, and cerebral vasospasm in a primate model of subarachnoid hemorrhage by JUNG, Carla S, IULIANO, Brian A, HARVEY-WHITE, Judith, ESPEY, Michael G, OLDFIELD, Edward H, PLUTA, Ryszard M

“…Decreased availability of nitric oxide (NO) has been proposed to evoke delayed cerebral vasospasm after sub-arachnoid hemorrhage (SAH). Asymmetric…”
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Delayed cerebral vasospasm and nitric oxide: review, new hypothesis, and proposed treatment by Pluta, Ryszard M

“…Despite years of research, delayed cerebral vasospasm remains the feared complication of a ruptured intracranial aneurysm. Worldwide effort has led to many…”
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Endothelial dysfunction in a primate model of cerebral vasospasm by IULIANO, Brian A, PLUTA, Ryszard M, JUNG, Carla, OLDFIELD, Edward H

“…Although abnormalities in the control of endothelial vasomotility have been reported in both experimental and clinical studies, the mechanism of the…”
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Brain Injury after Transient Global Cerebral Ischemia and Subarachnoid Hemorrhage by Sehba, Fatima A., Pluta, Ryszard M., Macdonald, R. Loch

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Nitrite infusion in humans and nonhuman primates : Endocrine effects, pharmacokinetics, and tolerance formation by DEJAM, André, HUNTER, Christian J, SCHECHTER, Alan N, GLADWIN, Mark T, TREMONTI, Carole, PLUTA, Ryszard M, YUEN YI HON, GRIMES, George, PARTOVI, Kristine, PELLETIER, Mildred M, OLDFIELD, Edward H, CANNON, Richard O

“…The recent discovery that nitrite is an intrinsic vasodilator and signaling molecule at near-physiological concentrations has raised the possibility that…”
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Nitrite Infusions to Prevent Delayed Cerebral Vasospasm in a Primate Model of Subarachnoid Hemorrhage by Pluta, Ryszard M, Dejam, Andre, Grimes, George, Gladwin, Mark T, Oldfield, Edward H

“…CONTEXT Delayed cerebral vasospasm causes permanent neurological deficits or death in at least 15% of patients following otherwise successful treatment for…”
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Cerebral vasospasm after subarachnoid hemorrhage: the emerging revolution by Macdonald, R Loch, Pluta, Ryszard M, Zhang, John H

“…Cerebral vasospasm is the classic cause of delayed neurological deterioration after aneurysmal subarachnoid hemorrhage, leading to cerebral ischemia and…”
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The emerging biology of the nitrite anion by Hogg, Neil, Cannon, Richard O, Kelm, Malte, Espey, Michael Graham, Schechter, Alan N, Lancaster, Jack R, Oldfield, Edward H, Feelisch, Martin, Wink, David A, Freeman, Bruce A, Gladwin, Mark T, Kim-Shapiro, Daniel B, Shiva, Sruti, Lundberg, Jon O, Patel, Rakesh P, Pluta, Ryszard M

“…Nitrite has now been proposed to play an important physiological role in signaling, blood flow regulation and hypoxic nitric oxide homeostasis. A recent…”
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Molsidomine for the prevention of vasospasm-related delayed ischemic neurological deficits and delayed brain infarction and the improvement of clinical outcome after subarachnoid hemorrhage: a single-center clinical observational study by Ehlert, Angelika, Schmidt, Christoph, Wölfer, Johannes, Manthei, Gerd, Jacobs, Andreas H, Brüning, Roland, Heindel, Walter, Ringelstein, E Bernd, Stummer, Walter, Pluta, Ryszard M, Hesselmann, Volker

“…OBJECT Delayed ischemic neurological deficits (DINDs) and cerebral vasospasm (CVS) are responsible fora poor outcome in patients with aneurysmal subarachnoid…”
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Prolonged intravenous infusion of sodium nitrite delivers nitric oxide (NO) in humans by Pluta, Ryszard M

“…In preclinical studies, infusion of sodium nitrite delivers nitric oxide (NO) as treatment of vasospasm after subarachnoid hemorrhage. We evaluated safety and…”
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Reversal of cerebral vasospasm via intravenous sodium nitrite after subarachnoid hemorrhage in primates: Laboratory investigation by REZA FATHI, Ali, PLUTA, Ryszard M, BAKHTIAN, Kamran D, MENG QI, LONSER, Russell R

“…Object Subarachnoid hemorrhage (SAH)-induced vasospasm is a significant underlying cause of aneurysm rupture-related morbidity and death. While long-term…”
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