Search Results - "Plumbly, William"

L-type voltage-gated calcium channel regulation of in vitro human cortical neuronal networks by Plumbly, William, Brandon, Nick, Deeb, Tarek Z., Hall, Jeremy, Harwood, Adrian J.

“…The combination of in vitro multi-electrode arrays (MEAs) and the neuronal differentiation of stem cells offers the capability to study human neuronal networks…”
Get full text

Unravelling cell type-specific responses to Parkinson's Disease at single cell resolution by Martirosyan, Araks, Ansari, Rizwan, Pestana, Francisco, Hebestreit, Katja, Gasparyan, Hayk, Aleksanyan, Razmik, Hnatova, Silvia, Poovathingal, Suresh, Marneffe, Catherine, Thal, Dietmar R, Kottick, Andrew, Hanson-Smith, Victor J, Guelfi, Sebastian, Plumbly, William, Belgard, T Grant, Metzakopian, Emmanouil, Holt, Matthew G

“…Parkinson's Disease (PD) is the second most common neurodegenerative disorder. The pathological hallmark of PD is loss of dopaminergic neurons and the presence…”
Get full text

Genome-wide CRISPR/Cas9 screen shows that loss of GET4 increases mitochondria-endoplasmic reticulum contact sites and is neuroprotective by Wilson, Emma L., Yu, Yizhou, Leal, Nuno S., Woodward, James A., Patikas, Nikolaos, Morris, Jordan L., Field, Sarah F., Plumbly, William, Paupe, Vincent, Chowdhury, Suvagata R., Antrobus, Robin, Lindop, Georgina E., Adia, Yusuf M., Loh, Samantha H. Y., Prudent, Julien, Martins, L. Miguel, Metzakopian, Emmanouil

“…Organelles form membrane contact sites between each other, allowing for the transfer of molecules and signals. Mitochondria-endoplasmic reticulum (ER) contact…”
Get full text

Correction: Unravelling cell type-specific responses to Parkinson's Disease at single cell resolution by Martirosyan, Araks, Ansari, Rizwan, Pestana, Francisco, Hebestreit, Katja, Gasparyan, Hayk, Aleksanyan, Razmik, Hnatova, Silvia, Poovathingal, Suresh, Marneffe, Catherine, Thal, Dietmar R, Kottick, Andrew, Hanson-Smith, Victor J, Guelfi, Sebastian, Plumbly, William, Belgard, T Grant, Metzakopian, Emmanouil, Holt, Matthew G

Get full text

Cortical neuronal hyperexcitability and synaptic changes in SGCE mutation-positive myoclonus dystonia by Sperandeo, Alessandra, Tamburini, Claudia, Noakes, Zoe, de la Fuente, Daniel Cabezas, Keefe, Francesca, Petter, Olena, Plumbly, William, Clifton, Nicholas E, Li, Meng, Peall, Kathryn J

“…Abstract Myoclonus dystonia is a childhood-onset hyperkinetic movement disorder with a combined motor and psychiatric phenotype. It represents one of the few…”
Get full text

Derivation of nociceptive sensory neurons from hiPSCs with early patterning and temporally controlled NEUROG2 overexpression by Plumbly, William, Patikas, Nikolaos, Field, Sarah F., Foskolou, Stefanie, Metzakopian, Emmanouil

“…Despite development of protocols to differentiate human pluripotent stem cells (hPSCs), those used to produce sensory neurons remain difficult to replicate and…”
Get full text

The creation of a platform for investigating the network function of human pluripotent stem cell derived neurons in development and disease by Plumbly, William

“…The formation and function of neural networks is a key aspect of normal brain development, while a converging body of evidence from human genetic and…”
Get full text