Search Results - "Plumb, R.S."

High Performance Thin-Layer Chromatography of Plant Ecdysteroids Coupled with Desorption Electrospray Ionisation–Ion Mobility–Time of Flight High Resolution Mass Spectrometry (HPTLC/DESI/IM/ToFMS) by Claude, E., Tower, M., Lafont, R., Wilson, I. D., Plumb, R. S.

“…The use of high performance thin-layer chromatography (HPTLC) in combination with high resolution time of flight mass spectrometry (MS) for the detection,…”
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Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct on-line analysis of pharmaceuticals in plasma by Ayrton, J, Dear, G.J, Leavens, W.J, Mallett, D.N, Plumb, R.S

“…The use of ultra-high flow-rate chromatography coupled to mass spectrometry offers great potential for the rapid, on-line analysis of pharmaceutical compounds…”
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Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography–mass spectrometry–nuclear magnetic resonance spectroscopy by Dear, G.J., Plumb, R.S., Sweatman, B.C., Ayrton, J., Lindon, J.C., Nicholson, J.K., Ismail, I.M.

“…Mass spectrometry (both MS and MS–MS) has been used to determine which eluting chromatography peaks in an LC–MS–nuclear magnetic resonance (NMR) experiment…”
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The application of microbore UPLC/oa-TOF-MS and 1H NMR spectroscopy to the metabonomic analysis of rat urine following the intravenous administration of pravastatin by Lenz, E.M., Williams, R.E., Sidaway, J., Smith, B.W., Plumb, R.S., Johnson, K.A., Rainville, P., Shockcor, J., Stumpf, C.L., Granger, J.H., Wilson, I.D.

“…The metabonomic effects of hepatotoxic doses of pravastatin on the urinary metabolic profiles of female rats have been investigated using ultra performance…”
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Direct analysis of a polar pharmaceutical compound in plasma using ultra-high flow rate liquid chromatography/mass spectrometry with a mixed-mode column by Mallett, D.N., Dear, G.J., Plumb, R.S.

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Use of generic fast gradient liquid chromatography–tandem mass spectroscopy in quantitative bioanalysis by Ayrton, J., Dear, G.J., Leavens, W.J., Mallett, D.N., Plumb, R.S.

“…Short narrow analytical HPLC columns have been used successfully with high linear flow-rates and combined with mass spectrometric detection to produce a…”
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Use of reduced sorbent bed and disk membrane solid-phase extraction for the analysis of pharmaceutical compounds in biological fluids, with applications in the 96-well format by Plumb, R.S., Gray, R.D.M., Jones, C.M.

“…Significant improvements in the isolation of pharmaceutical compounds from plasma, serum and urine, have been achieved using ultra low mass sorbent bed and…”
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Use of directly coupled ion-exchange liquid chromatography–mass spectrometry and liquid chromatography–nuclear magnetic resonance spectroscopy as a strategy for polar metabolite identification by Dear, G.J, Plumb, R.S, Sweatman, B.C, Parry, P.S, Roberts, A.D, Lindon, J.C, Nicholson, J.K, Ismail, I.M

“…Ion-exchange LC–MS and LC–NMR have been successfully used to identify a novel N-acetyl metabolite of a highly polar drug candidate…”
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High-performance chromatographic assay for the sulphoxide metabolite of 2′-deoxy-3′-thiacytidine in human urine by Plumb, R.S., Gray, R.D.M., Harker, A.J., Taylor, S.

“…A high-performance liquid chromatographic method is described for the determination in human urine of GI138870X, the sulphoxide metabolite of a novel…”
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Porous graphitic carbon shows promise for the rapid chromatographic analysis of polar drug metabolites by Ayrton, J., Evans, M.B., Harris, A.J., Plumb, R.S.

“…A rapid and simple HPLC method has been developed and used to separate the polar metabolic conjugates of AZT, chloramphenicol, and β-estradiol based upon the…”
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