Search Results - "Plum, Lori A."

Antibody production in mice requires neither vitamin D, nor the vitamin D receptor by Plum, Lori A., Blaser, William, Peter, Logan, Prahl, Jean, Seeman, Jeremy, DeLuca, Hector F.

“…The vitamin D receptor as well as its ligand have been localized to various immune tissues and cells. These observations have led researchers to hypothesize a…”
Get full text

Highlights from the 24th workshop on vitamin D in Austin, September 2022 by Meyer, Mark B., Bernal-Mizrachi, Carlos, Bikle, Daniel D., Biyani, Madhu, Campbell, Moray J., Chaudhari, Snehal N., Christakos, Sylvia, Ingles, Sue A., Knuth, Megan M., Lee, Seong Min, Lisse, Thomas S., Liu, Eva S., Piec, Isabelle, Plum, Lori A., Rao, Sudhaker D., Reynolds, Carmen J., Thacher, Tom D., White, John H., Cantorna, Margherita T.

“…The 24th Workshop on Vitamin D was held September 7-9, 2022 in Austin, Texas and covered a wide diversity of research in the vitamin D field from across the…”
Get full text

Vitamin D binding protein greatly improves bioactivity but is not essential for orally administered vitamin D by Duchow, Elizabeth G., Duchow, Mark W., Plum, Lori A., DeLuca, Hector F.

“…Vitamin D3 is a prohormone that is essential for calcium homeostasis. It is naturally produced in the skin by ultraviolet‐B (UVB) irradiation of…”
Get full text

Vitamin D deficiency in the ApcPirc/+ rat does not exacerbate colonic tumorigenesis, while low dietary calcium might be protective by Irving, Amy A., Duchow, Elizabeth G., Plum, Lori A., DeLuca, Hector F.

“…Human studies have shown that individuals with colon cancer tend to have lower serum 25-hydroxy-vitamin D3 [25(OH)D3] levels compared with healthy controls,…”
Get full text

Vitamin D receptor absence does not enhance intestinal tumorigenesis in ApcPirc/+ rats by Irving, Amy A, Waters, Bayley J, Seeman, Jeremy R, Plum, Lori A, DeLuca, Hector F

“…Epidemiological observations have prompted some to posit that elevated circulating vitamin D is responsible for reduced colon cancer in individuals residing…”
Get full text

Vitamin D, disease and therapeutic opportunities by DeLuca, Hector F, Plum, Lori A

“…Key Points The discovery of the vitamin D endocrine system in 1970 sparked a new interest in the relationship between vitamin D and metabolic bone disease. In…”
Get full text

Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase by Chiellini, Grazia, Rapposelli, Simona, Zhu, Jinge, Massarelli, Ilaria, Saraceno, Marilena, Bianucci, Anna Maria, Plum, Lori A., Clagett-Dame, Margaret, DeLuca, Hector F.

“…[Display omitted] ► Potent vitamin D-like CYP24 inhibitors are efficiently prepared in convergent syntheses. ► The 25- N-cyclopropylamine side chain modified…”
Get full text

2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 Potently Stimulates Gene-specific DNA Binding of the Vitamin D Receptor in Osteoblasts by Yamamoto, Hironori, Shevde, Nirupama K., Warrier, Anjali, Plum, Lori A., DeLuca, Hector F., Pike, J.Wesley

“…2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 (2MD) is a highly potent analog of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) whose actions are mediated through…”
Get full text

1-Desoxy analog of 2MD: Synthesis and biological activity of (20S)-25-hydroxy-2-methylene-19-norvitamin D3 by SIBILSKA, Izabela, BARYCKA, Katarzyna M, SICINSKI, Rafal R, PLUM, Lori A, DELUCA, Hector F

“…During our ongoing structure-activity studies in the vitamin D area, we obtained (20S)-1alpha,25-dihydroxy-2-methylene-19-norvitamin D3 (5). This analog,…”
Get full text

Vitamin D binding protein is required to utilize skin-generated vitamin D by Duchow, Elizabeth G., Cooke, Nancy E., Seeman, Jeremy, Plum, Lori A., DeLuca, Hector F.

“…Vitamin D is produced in the skin following exposure to sunlight. Ultraviolet (UV) B (UVB, 280–310 nm) results in isomerization of 7-dehydrocholesterol to…”
Get full text

UV light suppression of EAE (a mouse model of multiple sclerosis) is independent of vitamin D and its receptor by Irving, Amy A., Marling, Steven J., Seeman, Jeremy, Plum, Lori A., DeLuca, Hector F.

“…Vitamin D and sunlight have each been reported to protect against the development of experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple…”
Get full text

Design, synthesis, and biological activity of D-bishomo-1α,25-dihydroxyvitamin D3 analogs and their crystal structures with the vitamin D nuclear receptor by Fabisiak, Adrian, Brzeminski, Pawel, Sicinski, Rafal R., Rochel, Natacha, Maj, Ewa, Filip-Psurska, Beata, Wietrzyk, Joanna, Plum, Lori A., DeLuca, Hector F.

“…The biologically active metabolite of vitamin D3 - calcitriol – is a hormone involved in the regulation of calcium-phosphate homeostasis, immunological…”
Get full text

Design, synthesis, and biological activity of D-bishomo-1α,25-dihydroxyvitamin D 3 analogs and their crystal structures with the vitamin D nuclear receptor by Fabisiak, Adrian, Brzeminski, Pawel, Sicinski, Rafal R, Rochel, Natacha, Maj, Ewa, Filip-Psurska, Beata, Wietrzyk, Joanna, Plum, Lori A, DeLuca, Hector F

“…The biologically active metabolite of vitamin D - calcitriol - is a hormone involved in the regulation of calcium-phosphate homeostasis, immunological…”
Get full text

Synthesis and Biological Activity of 2,22-Dimethylene Analogues of 19-Norcalcitriol and Related Compounds by Sibilska-Kaminski, Izabela K, Sicinski, Rafal R, Plum, Lori A, DeLuca, Hector F

“…Continuing our search for vitamin D analogues, we explored the modification of the steroidal side chain and inserted a methylene moiety in position C-22…”
Get full text

1,25-Dihydroxyvitamin D is not responsible for toxicity caused by vitamin D or 25-hydroxyvitamin D by DeLuca, Hector F., Prahl, Jean M., Plum, Lori A.

“…► 1,25-Dihydroxyvitamin D is not responsible for vitamin D intoxication. ► 25-Hydroxyvitamin D is likely responsible for vitamin D3 intoxication. ► CYP27B1…”
Get full text

A New 1,25 Dihydroxy Vitamin D Analog with Strong Bone Anabolic Activity in OVX Rats with Little or no Bone Resorptive Activity by Plum, Lori A, Zella, Julia, Clagett‐Dame, Margaret, DeLuca, Hector F

“…ABSTRACT A new 1α,25‐dihydroxy vitamin D3 analog (2‐methylene‐22(E)‐(24R)‐22‐dehydro‐1α,24,25‐trihydroxy‐19‐norvitamin D3 or WT‐51) has been tested as a…”
Get full text

Vitamin D deficiency independent of hypocalcemia elevates blood pressure in rats by Sundersingh, Flora, Plum, Lori A., DeLuca, Hector F.

“…Essential hypertension is a polygenic disorder with a complex and multifactorial nature. Although no single gene is responsible, multiple genes provide…”
Get full text

Salate derivatives found in sunscreens block experimental autoimmune encephalomyelitis in mice by Wang, Yanping, Marling, Steven J., Plum, Lori A., DeLuca, Hector F.

“…UV light suppresses experimental autoimmune encephalomyelitis (EAE), a widely used animal model of MS, in mice and may be responsible for the decreased…”
Get full text

Vitamin D deficiency diminishes the severity and delays onset of experimental autoimmune encephalomyelitis by DeLuca, Hector F., Plum, Lori A.

“…► Severe vitamin D deficiency reduces severity and onset of EAE in susceptible mice. ► Administration of vitamin D largely restores susceptibility to EAE. ►…”
Get full text

2MD, a new anabolic agent for osteoporosis treatment by PLUM, L. A, FITZPATRICK, L. A, MA, X, BINKLEY, N. C, ZELLA, J. B, CLAGETT-DAME, M, DELUCA, H. F

“…2-Methylene-19-nor-(20S)-1alpha,25-dihydroxyvitamin D3 (2MD) is a new analog of 1alpha,25-dihydroxyvitamin D3 (1,25-(OH)2D3) that has unique properties…”
Get full text