Search Results - "Plum, G. E."

Conformational Energetics of Stable and Metastable States Formed by DNA Triplet Repeat Oligonucleotides: Implications for Triplet Expansion Diseases by Völker, J., Makube, N., Plum, G. E., Klump, H. H., Breslauer, K. J.

“…We have embedded the hexameric triplet repeats (CAG)6and (CTG)6between two (GC)3domains to produce two 30-mer hairpins with the sequences d[(GC)3(CAG)6(GC)3]…”
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On chip quadruplex priming amplification for quantitative isothermal diagnostics by Pease, C., Plum, G. E., Kankia, B., Kwiek, J. J., Sooryakumar, R.

“…Nucleic acid testing is a common technique for medical diagnostics. For example, it is used to detect HIV treatment failure by monitoring viral load levels…”
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Thermodynamic Characterization of the Stability and the Melting Behavior of a DNA Triplex: A Spectroscopic and Calorimetric Study by Plum, G. Eric, Park, Young-Whan, Singleton, Scott F., Dervan, Peter B., Breslauer, Kenneth J.

“…We report a complete thermodynamic characterization of the stability and the melting behavior of an oligomeric DNA triplex. The triplex chosen for study forms…”
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A More Unified Picture for the Thermodynamics of Nucleic Acid Duplex Melting: A Characterization by Calorimetric and Volumetric Techniques by Chalikian, Tigran V., Völker, Jens, Plum, G. Eric, Breslauer, Kenneth J.

“…We use a combination of calorimetric and volumetric techniques to detect and to characterize the thermodynamic changes that accompany helix-to-coil transitions…”
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Influence of an exocyclic guanine adduct on the thermal stability, conformation, and melting thermodynamics of a DNA duplex by Plum, G. Eric, Grollman, Arthur P, Johnson, Frances, Breslauer, Kenneth J

“…As part of an overall program to characterize the impact of mutagenic lesions on the physiochemical properties of DNA, we report here the results of a…”
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Thermodynamic Consequences of an Abasic Lesion in Duplex DNA Are Strongly Dependent on Base Sequence by Gelfand, Craig A, Plum, G. Eric, Grollman, Arthur P, Johnson, Francis, Breslauer, Kenneth J

“…The abasic site in DNA may arise spontaneously, as a result of nucleotide base damage, or as an intermediate in glycosylase-mediated DNA-repair pathways. It is…”
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Influence of the Oxidatively Damaged Adduct 8-Oxodeoxyguanosine on the Conformation, Energetics, and Thermodynamic Stability of a DNA Duplex by Plum, G. Eric, Grollman, Arthur P, Johnson, Francis, Breslauer, Kenneth J

“…As part of an overall program to characterize the impact of mutagenic lesions on the physiochemical properties of DNA, we report here the results of a…”
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Structural and electrostatic effects on binding of trivalent cations to double-stranded and single-stranded poly[d (AT)] by Plum, G E, Bloomfield, V A

“…We have measured the thermal melting profile for poly[d(AT)].poly[d(TA)] as a function of concentration of three trivalent cations: spermidine, me8spermidine,…”
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Berenil [1,3-bis(4'-amidinophenyl)triazene] binding to DNA duplexes and to a RNA duplex: evidence for both intercalative and minor groove binding properties by Pilch, D S, Kirolos, M A, Liu, X, Plum, G E, Breslauer, K J

“…Berenil is an antitrypanosomal agent that binds to nucleic acid duplexes. The generally accepted mode of berenil binding is via complexation into the minor…”
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Thermodynamics of an Intramolecular DNA Triple Helix: A Calorimetric and Spectroscopic Study of the pH and Salt Dependence of Thermally Induced Structural Transitions by Plum, Eric G., Breslauer, Kenneth J.

“…We have characterized thermodynamically the melting transitions of a DNA 31-mer oligonucleotide (5′-GAAGAGGTTTTTCCTCTTCTTTTTCTTCTCC-3′) which is designed to…”
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Influence of base composition, base sequence, and duplex structure on DNA hydration: apparent molar volumes and apparent molar adiabatic compressibilities of synthetic and natural DNA duplexes at 25 degrees C by Chalikian, T V, Sarvazyan, A P, Plum, G E, Breslauer, K J

“…Using high-precision densitometric and ultrasonic measurements, we have determined, at 25 degrees C, the apparent molar volumes, phi V, and the apparent molar…”
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Effects of spermidine and hexaamminecobalt(III) on thymine imino proton exchange by Plum, G. Eric, Bloomfield, Victor A

“…We examine the influence of spermidine and hexaamminecobalt(III) binding on DNA base pair dynamics. Proton NMR line-width measurements are used to monitor the…”
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Contribution of asymmetric ligand binding to the apparent permanent dipole moment of DNA by Plum, G E, Bloomfield, V A

“…Despite its antiparallel symmetry, DNA often appears to possess a permanent electric dipole moment in transient electro-optical experiments. We propose that…”
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The thermodynamics of DNA structures that contain lesions of guanine tetrads by Pilch, Daniel S, Plum, G Eric, Breslauer, Kenneth J

“…It is becoming increasingly apparent that energetic as well as structural information is required to develop a complete appreciation of the critical…”
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Optical methods by Plum, G E

“…Equilibrium optical melting curves are used in this unit to determine thermodynamic parameters of nucleic acid complex formation. This section contains all of…”
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A Quantitative Method for Evaluating the Stabilities of Nucleic Acids by Gelfand, Craig A., Plum, G. Eric, Mielewczyk, Slawomir, Remeta, David P., Breslauer, Kenneth J.

“…We report a general method for screening, in solution, the impact of deviations from canonical Watson-Crick composition on the thermodynamic stability of…”
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Fluorescence energy transfer monitored competitive equilibria of nucleic acids: Applications in thermodynamics and screening by Plum, G. Eric, Breslauer, Kenneth J.

“…Precise thermodynamic characterization of nucleic acid complex stability is required to understand a variety of biologically significant events as well as to…”
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Calorimetry of proteins and nucleic acids by Plum, G Eric, Breslauer, Kenneth J

“…The availability of sensitive calorimetric instrumentation has led to a considerable increase in thermodynamic studies of proteins, nucleic acids, and their…”
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Effects of 3,N4-ethenodeoxycytidine on duplex stability and energetics by Plum, G E, Gelfand, C A, Breslauer, K J

“…The exocyclic cytosine adduct 3,N4-ethenocytosine is highly mutagenic in mammalian cells. We describe the impact of this adduct on DNA duplex stability. The…”
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The Impact of an Exocyclic Cytosine Adduct on DNA Duplex Properties:  Significant Thermodynamic Consequences Despite Modest Lesion-Induced Structural Alterations by Gelfand, Craig A, Plum, G. Eric, Grollman, Arthur P, Johnson, Francis, Breslauer, Kenneth J

“…The exocyclic base adduct 3,N 4-deoxyethenocytosine (εC) is a common DNA lesion that can arise from carcinogen exposure and/or as a biproduct of cellular…”
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