Search Results - "Plowman, Jacqueline"

Preclinical antitumor activity of batracylin (NSC 320846) by PLOWMAN, J, PAULL, K. D, ATASSI, G, HARRISON, S. D. JR, DYKES, D. J, KABBE, H. J, NARAYANAN, V. L, YODER, O. C

“…Batracylin (NSC 320846, BAY H 2049), given ip on days 2 and 9 at a dose 400 mg/kg, inhibited tumor growth completely in 80-100% of mice with early-stage colon…”
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Echinomycin: the first bifunctional intercalating agent in clinical trials by Foster, B J, Clagett-Carr, K, Shoemaker, D D, Suffness, M, Plowman, J, Trissel, L A, Grieshaber, C K, Leyland-Jones, B

“…Echinomycin is a quinoxaline antibiotic that was originally isolated from Streptomyces echinatus. Based on its antitumor activity against two i.p. implanted…”
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Antitumor 2,3-dihydro-2-(aryl)-4(1 H)-quinazolinone derivatives : Interactions with tubulin by Hamel, Ernest, Lin, Chii M., Plowman, Jacqueline, Wang, Hui-Kang, Lee, Kuo-Hsiung, D. Paull, Kenneth

“…A series of derivatives of 2,3-dihydro-2-(aryl)-4(1 H)-quinazolinone (DHQZ) with known antitumor activity was re-evaluated in the National Cancer Institute…”
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Studies on synthesis and anticancer activity of selected N-(2-fluoroethyl)-N-nitrosoureas by Johnston, Thomas P, Kussner, Conrad L, Carter, Ronald L, Frye, Jerry L, Lomax, Nancita R, Plowman, Jacqueline, Narayanan, V. L

“…An activated carbamate, 2-nitrophenyl (2-fluoroethyl)nitrosocarbamate (3), was used to advantage in the synthesis of the water-soluble…”
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Purification and Properties of Guanosine Triphosphate Cyclohydrolase and a Stimulating Protein from Comamonas Sp. (ATCC 11299a) by Cone, J E, Plowman, J, Guroff, G

“…GTP cyclohydrolase and a stimulating protein were purified from extracts of Comamonas sp. (ATCC 11299a). The enzyme, designated Fraction A, catalyzed the…”
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Identification of d-erythro-Dihydroneopterin Triphosphate, the First Product of Pteridine Biosynthesis in Comamonas Sp. (ATCC 11299a) by Plowman, J, Cone, J E, Guroff, G

“…GTP cyclohydrolase, purified from extracts of Comamonas sp., was shown to convert GTP to formic acid and a single fluorescent compound. The fluorescent product…”
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Preclinical antitumor activity of temozolomide in mice : efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-1-nitrosourea by PLOWMAN, J, WAUD, W. R, KOUTSOUKOS, A. D, RUBINSTEIN, L. V, MOORE, T. D, GREVER, M. R

“…Temozolomide, a methylating agent with clinical activity against brain tumors, demonstrated excellent antitumor activity following p.o. administration to…”
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Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione by Ozols, R F, Louie, K G, Plowman, J, Behrens, B C, Fine, R L, Dykes, D, Hamilton, T C

“…The development of acquired resistance to alkylating agents frequently limits the effectiveness of chemotherapy in the treatment of ovarian cancer. While the…”
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Antitumor activity and biochemical effects of aphidicolin glycinate (NSC 303812) alone and in combination with cisplatin in vivo by O'DWYER, P. J, MOYER, J. D, SUFFNESS, M, HARRISON, S. D, CYSYK, R, HAMILTON, T. C, PLOWMAN, J

“…Aphidicolin, an inhibitor of DNA polymerases alpha and delta, is cytotoxic in vitro against tumor cells. The poor solubility of aphidicolin has led to the…”
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Antitumor 2,3-dihydro-2-(aryl)-4(1H)-quinazolinone derivatives by Hamel, Ernest, Lin, Chii M., Plowman, Jacqueline, Wang, Hui-Kang, Lee, Kuo-Hsiung, D. Paull, Kenneth

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2-(Aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines, a new class of anticancer agents by Capps, David B, Dunbar, James, Kesten, Suzanne R, Shillis, Joan, Werbel, Leslie M, Plowman, Jacqueline, Ward, Donald L

“…2-(Aminoalkyl)-5-nitropyrazolo[3,4,5-kl]acridines were prepared from substituted anilines via the 1-chloro-4-nitroacridones followed by condensation with…”
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Efficacy of the quinocarmycins KW2152 and DX-52-1 against human melanoma lines growing in culture and in mice by PLOWMAN, J, DYKES, D. J, NARAYANAN, V. L, ABBOTT, B. J, SAITO, H, HIRATA, T, GREVER, M. R

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Synthesis, antitumor activity, and chemical properties of silaplatin and related platinum(II) and platinum(IV) complexes derived from .beta.-silyl amines by Anderson, Wayne K, Kasliwal, Ravindra, Houston, D. Michael, Wang, Yueh-sha, Narayanan, Ven L, Haugwitz, Rudiger D, Plowman, Jacqueline

“…Platinum (II) and platinum (IV) coordination complexes derived from beta-silyl-substituted amines were prepared. The solubility of selected complexes in water…”
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Preclinical antitumor activity of bizelesin in mice by CARTER, C. A, WAUD, W. R, LI, L. H, DEKONING, T. F, MCGOVREN, J. P, PLOWMAN, J

“…Bizelesin (U-77779, NSC 615291), a synthetic analogue of the cytotoxic antibiotic CC-1065, is a bifunctional alkylating agent that produces DNA interstrand…”
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Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogs by Driscoll, John S, Marquez, Victor E, Plowman, Jacqueline, Liu, Paul S, Kelley, James A, Barchi, Joseph J

“…2(1H)-Pyrimidinone riboside (zebularine, 1b) and its 5-fluoro (6b) and 2'-ara-fluoro (7b) analogues have been synthesized and evaluated in vivo as antitumor…”
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Anthrapyrazoles, a new class of intercalating agents with high-level, broad spectrum activity against murine tumors by LEOPOLD, W. R, NELSON, J. M, PLOWMAN, J, JACKSON, R. C

“…A series of 5-[(aminoalkyl)amino]-substituted anthra[1,9-cd] pyrazol-6(2H)ones (anthrapyrazoles) were synthesized. These compounds, which differ from the…”
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Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties by Marquez, Victor E, Lim, Mu Ill, Treanor, Susan P, Plowman, Jacqueline, Priest, Matthew A, Markovac, Anica, Khan, M. Sami, Kaskar, Bashir, Driscoll, John S

“…Cyclopentenylcytosine (CPE-C, 2), a pyrimidine analogue of the fermentation derived carbocyclic nucleoside neplanocin A, has been synthesized from the…”
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L-histidinol : preclinical therapeutic studies in combination with antitumor agents and pharmacokinetic studies in mice by ZAHARKO, D, PLOWMAN, J, WAUD, W, DYKES, D, MALSPEIS, L

“…Therapeutic studies were conducted with L-histidinol, in combination with cyclophosphamide, bischloroethylnitrosourea, 5-fluorouracil, phenylalanine mustard,…”
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Activity of flavone acetic acid (NSC-347512) against solid tumors of mice by Corbett, T H, Bissery, M C, Wozniak, A, Plowman, J, Polin, L, Tapazoglou, E, Dieckman, J, Valeriote, F

“…Flavone acetic acid (FAA) is a new antitumor agent that has recently entered Phase I clinical trials. In preclinical studies, we have found that FAA was…”
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In vitro and in vivo evaluation of US-NCI compounds in human tumor xenografts by Fiebig, H H, Berger, D P, Winterhalter, B R, Plowman, J

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