Search Results - "Plowman, Gregory D."

Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers by Peng, Sheng-Bin, Henry, James R., Kaufman, Michael D., Lu, Wei-Ping, Smith, Bryan D., Vogeti, Subha, Rutkoski, Thomas J., Wise, Scott, Chun, Lawrence, Zhang, Youyan, Van Horn, Robert D., Yin, Tinggui, Zhang, Xiaoyi, Yadav, Vipin, Chen, Shih-Hsun, Gong, Xueqian, Ma, Xiwen, Webster, Yue, Buchanan, Sean, Mochalkin, Igor, Huber, Lysiane, Kays, Lisa, Donoho, Gregory P., Walgren, Jennie, McCann, Denis, Patel, Phenil, Conti, Ilaria, Plowman, Gregory D., Starling, James J., Flynn, Daniel L.

“…LY3009120 is a pan-RAF and RAF dimer inhibitor that inhibits all RAF isoforms and occupies both protomers in RAF dimers. Biochemical and cellular analyses…”
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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen by Poole, Andrew, Karuppiah, Vijaykumar, Hartt, Annabelle, Haidar, Jaafar N., Moureau, Sylvie, Dobrzycki, Tomasz, Hayes, Conor, Rowley, Christopher, Dias, Jorge, Harper, Stephen, Barnbrook, Keir, Hock, Miriam, Coles, Charlotte, Yang, Wei, Aleksic, Milos, Lin, Aimee Bence, Robinson, Ross, Dukes, Joe D., Liddy, Nathaniel, Van der Kamp, Marc, Plowman, Gregory D., Vuidepot, Annelise, Cole, David K., Whale, Andrew D., Chillakuri, Chandramouli

“…Neoantigens derived from somatic mutations are specific to cancer cells and are ideal targets for cancer immunotherapy. KRAS is the most frequently mutated…”
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Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade by Holmgaard, Rikke B, Schaer, David A, Li, Yanxia, Castaneda, Stephen P, Murphy, Mary Y, Xu, Xiaohong, Inigo, Ivan, Dobkin, Julie, Manro, Jason R, Iversen, Philip W, Surguladze, David, Hall, Gerald E, Novosiadly, Ruslan D, Benhadji, Karim A, Plowman, Gregory D, Kalos, Michael, Driscoll, Kyla E

“…TGFβ signaling plays a pleotropic role in tumor biology, promoting tumor proliferation, invasion and metastasis, and escape from immune surveillance…”
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Evolution of protein kinase signaling from yeast to man by Manning, Gerard, Plowman, Gregory D, Hunter, Tony, Sudarsanam, Sucha

“…Protein phosphorylation controls many cellular processes, especially those involved in intercellular communication and coordination of complex functions. To…”
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Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models by Hamilton, Patricia, Devasthali, Vidusha, Bou Reslan, Hani, Nannini, Michelle A, Cheng, Jason H, Johnson, Leisa, Ho, Calvin C K, Lee, Chingwei V, Fuh, Germaine, Forrest, William F, Molina, Rafael, Clermont, Anne C, Cao, Timothy C, Carano, Richard A D, Yu, Ron X, Koeppen, Hartmut, Plowman, Gregory D, Singh, Mallika, Lima, Anthony, Thompson, Jennifer D

“…Genetically engineered mouse models of cancer simulate the spontaneous development of tumors in their native tissue environment. Singh et al . establish their…”
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Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung by Holzer, Timothy R, Fulford, Angie D, Nedderman, Drew M, Umberger, Tara S, Hozak, Rebecca R, Joshi, Adarsh, Melemed, Symantha A, Benjamin, Laura E, Plowman, Gregory D, Schade, Andrew E, Ackermann, Bradley L, Konrad, Robert J, Nasir, Aejaz

“…A robust immunohistochemical (IHC) assay for VEGFR2 was developed to investigate its utility for patient tailoring in clinical trials. The sensitivity,…”
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The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis by Bischoff, James R, Plowman, Gregory D

“…Members of the Aurora/Ipl1p family of mitotically regulated serine/threonine kinases are emerging as key regulators of chromosome segregation and cytokinesis…”
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The Protein Kinases of Caenorhabditis elegans: A Model for Signal Transduction in Multicellular Organisms by Plowman, Gregory D., Sudarsanam, Sucha, Bingham, Jonathan, Whyte, David, Hunter, Tony

“…Caenorhabditis elegans should soon be the first multicellular organism whose complete genomic sequence has been determined. This achievement provides a unique…”
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Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene by Gong, Xueqian, Du, Jian, Parsons, Stephen H, Merzoug, Farhana F, Webster, Yue, Iversen, Philip W, Chio, Li-Chun, Van Horn, Robert D, Lin, Xi, Blosser, Wayne, Han, Bomie, Jin, Shaoling, Yao, Sufang, Bian, Huimin, Ficklin, Chris, Fan, Li, Kapoor, Avnish, Antonysamy, Stephen, Mc Nulty, Ann M, Froning, Karen, Manglicmot, Danalyn, Pustilnik, Anna, Weichert, Kenneth, Wasserman, Stephen R, Dowless, Michele, Marugán, Carlos, Baquero, Carmen, Lallena, María José, Eastman, Scott W, Hui, Yu-Hua, Dieter, Matthew Z, Doman, Thompson, Chu, Shaoyou, Qian, Hui-Rong, Ye, Xiang S, Barda, David A, Plowman, Gregory D, Reinhard, Christoph, Campbell, Robert M, Henry, James R, Buchanan, Sean G

“…Loss-of-function mutations in the retinoblastoma gene are common in several treatment-refractory cancers such as small-cell lung cancer and triple-negative…”
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Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120 by Chen, Shih-Hsun, Zhang, Youyan, Van Horn, Robert D, Yin, Tinggui, Buchanan, Sean, Yadav, Vipin, Mochalkin, Igor, Wong, Swee Seong, Yue, Yong Gang, Huber, Lysiane, Conti, Ilaria, Henry, James R, Starling, James J, Plowman, Gregory D, Peng, Sheng-Bin

“…We have identified previously undiscovered BRAF in-frame deletions near the αC-helix region of the kinase domain in pancreatic, lung, ovarian, and thyroid…”
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ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine by Bhagwat, Shripad V, McMillen, William T, Cai, Shufen, Zhao, Baohui, Whitesell, Matthew, Shen, Weihua, Kindler, Lisa, Flack, Robert S, Wu, Wenjuan, Anderson, Bryan, Zhai, Yan, Yuan, Xiu-Juan, Pogue, Meghann, Van Horn, Robert D, Rao, Xi, McCann, Denis, Dropsey, Andrew J, Manro, Jason, Walgren, Jennie, Yuen, Eunice, Rodriguez, Michael J, Plowman, Gregory D, Tiu, Ramon V, Joseph, Sajan, Peng, Sheng-Bin

“…The ERK pathway is critical in oncogenesis; aberrations in components of this pathway are common in approximately 30% of human cancers. ERK1/2 (ERK) regulates…”
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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy by Du, Jian, Yan, Lei, Torres, Raquel, Gong, Xueqian, Bian, Huimin, Marugán, Carlos, Boehnke, Karsten, Baquero, Carmen, Hui, Yu-Hua, Chapman, Sonya C, Yang, Yanzhu, Zeng, Yi, Bogner, Sarah M, Foreman, Robert T, Capen, Andrew, Donoho, Gregory P, Van Horn, Robert D, Barnard, Darlene S, Dempsey, Jack A, Beckmann, Richard P, Marshall, Mark S, Chio, Li-Chun, Qian, Yuewei, Webster, Yue W, Aggarwal, Amit, Chu, Shaoyou, Bhattachar, Shobha, Stancato, Louis F, Dowless, Michele S, Iversen, Phillip W, Manro, Jason R, Walgren, Jennie L, Halstead, Bartley W, Dieter, Matthew Z, Martinez, Ricardo, Bhagwat, Shripad V, Kreklau, Emiko L, Lallena, Maria Jose, Ye, Xiang S, Patel, Bharvin K R, Reinhard, Christoph, Plowman, Gregory D, Barda, David A, Henry, James R, Buchanan, Sean G, Campbell, Robert M

“…Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression…”
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Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations by Yao, Yung-Mae M, Donoho, Gregory P, Iversen, Philip W, Zhang, Youyan, Van Horn, Robert D, Forest, Amelie, Novosiadly, Ruslan D, Webster, Yue Wang, Ebert, Philip, Bray, Steven, Ting, Jason C, Aggarwal, Amit, Henry, James R, Tiu, Ramon V, Plowman, Gregory D, Peng, Sheng-Bin

“…To evaluate the antitumor efficacy of cetuximab in combination with LSN3074753, an analog of LY3009120 and pan-RAF inhibitor in 79 colorectal cancer…”
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Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity by Kotanides, Helen, Sattler, Rose Marie, Lebron, Maria B, Carpenito, Carmine, Shen, Juqun, Li, Jingxing, Surguladze, David, Haidar, Jaafar N, Burns, Colleen, Shen, Leyi, Inigo, Ivan, Pennello, Anthony L, Forest, Amelie, Chen, Xinlei, Chin, Darin, Sonyi, Andreas, Topper, Michael, Boucher, Lauren, Sharma, Prachi, Zhang, Yiwei, Burtrum, Douglas, Novosiadly, Ruslan D, Ludwig, Dale L, Plowman, Gregory D, Kalos, Michael

“…The CD137 receptor plays a key role in mediating immune response by promoting T cell proliferation, survival, and memory. Effective agonism of CD137 has the…”
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Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome by Friedman, Lori, Deal, Jennifer E, Howie, Elizabeth, Tan, Lory R, Edgar, Kyle A, Plowman, Gregory D, Marcinko, Marie, Winter, Christopher G, Milash, Brett, Winner, Millicent A, Cook, Kevin R, Parks, Annette L, Belvin, Marcia, Fawcett, Robert, Andrade, Rachel S, Kopczynski, Casey, Killpack, Keith, Duyk, Geoffrey, Grant, Deanna, Shaw, Kenneth J, Huppert, Kari, Miyazaki, Wesley Y, Margolis, Jonathan, Tabios, Mariano, Thao, Doua, Vysotskaia, Valentina, Kaufman, Thomas C, Zhao, Lora, Francis-Lang, Helen L, Robertson, Stephanie, Dompe, Nicholas A, Curtis, Daniel, Whittaker, Kellie, Deal-Herr, Megan E, Norton, Amanda, Bogart, Kevin P, Singer, Matthew A

“…In fruit fly research, chromosomal deletions are indispensable tools for mapping mutations, characterizing alleles and identifying interacting loci. Most…”
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Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family by Shoyab, Mohammed, Plowman, Gregory D., McDonald, Vicki L., Bradley, J. Garrett, Todaro, George J.

“…The complete amino acid sequence of amphiregulin, a bifunctional cell growth modulator, was determined. The truncated form contains 78 amino acids, whereas a…”
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The protein kinases of budding yeast: six score and more by Hunter, Tony, Plowman, Gregory D.

“…The completion of the budding yeast genome sequencing project has made it possible to determine not only the total number of genes, but also the exact number…”
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Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions by Peles, Elior, Nativ, Moshe, Lustig, Marc, Grumet, Martin, Schilling, James, Martinez, Ricardo, Plowman, Gregory D., Schlessinger, Joseph

“…Receptor protein tyrosine phosphatase β (RPTPβ) expressed on the surface of glial cells binds to the glycosylphosphatidylinositol (GPI)‐anchored recognition…”
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The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin by Peles, Elior, Nativ, Moshe, Campbell, Phillip L, Sakurai, Takeshi, Martinez, Ricardo, Levt, Sima, Clary, Douglas O, Schilling, James, Barnea, Gilad, Plowman, Gregory D, Grumet, Martin, Schlessinger, Joseph

“…Receptor-type protein tyrosine phosphatase β (RPTPβ) is expressed in the developing nervous system and contains a carbonic anhydrase (CAH) domain as well as a…”
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Neuregulins Signaling via a Glial erbB-2-erbB-4 Receptor Complex Contribute to the Neuroendocrine Control of Mammalian Sexual Development by Ma, Ying J, Hill, Diane F, Creswick, Kimberly E, Costa, Maria E, Cornea, Anda, Lioubin, Mario N, Plowman, Gregory D, Ojeda, Sergio R

“…Activation of erbB-1 receptors by glial TGFalpha has been shown to be a component of the developmental program by which the neuroendocrine brain controls…”
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