Search Results - "Plotsky, Paul"

Forced swimming-induced oxytocin release into blood and brain: Effects of adrenalectomy and corticosterone treatment by Torner, Luz, Plotsky, Paul M, Neumann, Inga D, De Jong, Trynke R

“…Highlights • Adrenalectomy (ADX) caused an exaggerated secretion of OXT into the blood in response to forced swim stress (FS), which was not reversed by acute…”
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Long-term behavioural and molecular alterations associated with maternal separation in rats by Lippmann, Melanie, Bress, Aaron, Nemeroff, Charles B., Plotsky, Paul M., Monteggia, Lisa M.

“…In this study we addressed whether certain behavioural measures, endocrine levels and specific stress‐related proteins exhibit long‐term alterations in adult…”
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Importance of Studying the Contributions of Early Adverse Experience to Neurobiological Findings in Depression by HEIM, Christine, PLOTSKY, Paul M, NEMEROFF, Charles B

“…Almost four decades of intensive research have sought to elucidate the neurobiological bases of depression. Epidemiological studies have revealed that both…”
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Locus Coeruleus Noradrenergic Modulation of Diurnal Corticosterone, Stress Reactivity, and Cardiovascular Homeostasis in Male Rats by Thrivikraman, K V, Kinkead, Becky, Owens, Michael J, Rapaport, Mark H, Plotsky, Paul M

“…Activation of the locus coeruleus-noradrenergic (LC-NA) system during awakening is associated with an increase in plasma corticosterone and cardiovascular…”
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Long-Term Consequences of Neonatal Rearing on Central Corticotropin-Releasing Factor Systems in Adult Male Rat Offspring by PLOTSKY, Paul M, THRIVIKRAMAN, K. V, NEMEROFF, Charles B, CALDJI, Christian, SHARMA, Shakti, MEANEY, Michael J

“…In a series of studies on the long-term consequences of neonatal rearing, we compared hypothalamic and extrahypothalamic central corticotropin-releasing factor…”
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Environmental Enrichment Reverses the Effects of Maternal Separation on Stress Reactivity by Francis, Darlene D, Diorio, Josie, Plotsky, Paul M, Meaney, Michael J

“…Postnatal maternal separation increases hypothalamic corticotropin-releasing factor (CRF) gene expression and hypothalamic-pituitary-adrenal (HPA) and…”
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Long-term adaptations in glucocorticoid receptor and mineralocorticoid receptor mrna and negative feedback on the hypothalamo-pituitary-adrenal axis following neonatal maternal separation by Ladd, Charlotte O, Huot, Rebecca L, Thrivikraman, K.V, Nemeroff, Charles B, Plotsky, Paul M

“…Maternally separated rats exhibit exaggerated hypothalamic-pituitary-adrenal responses to an acute stressor but normal diurnal trough functioning. We…”
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Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats by Huot, Rebecca L, Plotsky, Paul M, Lenox, Robert H, McNamara, Robert K

“…Neonatal maternal separation of rat pups leads to a stable stress hyper-responsive phenotype characterized by increased basal levels of corticotropin releasing…”
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International Union of Pharmacology. XXXVI. Current Status of the Nomenclature for Receptors for Corticotropin-Releasing Factor and Their Ligands by Hauger, Richard L, Grigoriadis, Dimitri E, Dallman, Mary F, Plotsky, Paul M, Vale, Wylie W, Dautzenberg, Frank M

“…Receptors for corticotropin-releasing factor (CRF) are members of a family of G protein-coupled receptors (“Family B”) that respond to a variety of…”
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Chronic maternal stress inhibits the capacity to up-regulate placental 11β-hydroxysteroid dehydrogenase type 2 activity by Welberg, Leonie A M, Thrivikraman, K V, Plotsky, Paul M

“…This study investigated the effects of acute and chronic restraint stress during the third week of pregnancy on placental 11β-hydroxysteroid dehydrogenase type…”
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Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression by Gardner, Katherine L, Hale, Matthew W, Lightman, Stafford L, Plotsky, Paul M, Lowry, Christopher A

“…Abstract Anxiety disorders, depression and animal models of vulnerability to a depression-like syndrome have been associated with dysregulation of serotonergic…”
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Early adverse experience as a developmental risk factor for later psychopathology: evidence from rodent and primate models by Sánchez, M M, Ladd, C O, Plotsky, P M

“…Increasing evidence supports the view that the interaction of perinatal exposure to adversity with individual genetic liabilities may increase an individual's…”
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Maternal separation alters drug intake patterns in adulthood in rats by Moffett, M.C., Vicentic, A., Kozel, Marie, Plotsky, Paul, Francis, D.D., Kuhar, M.J.

“…Maternal separation/handling (MS/H) is an animal model of early life stress that causes profound neurochemical and behavioral alterations in pups that persist…”
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Effects of early adverse experiences on brain structure and function: clinical implications by Kaufman, Joan, Plotsky, Paul M, Nemeroff, Charles B, Charney, Dennis S

“…Child abuse is associated with markedly elevated rates of major depression and other psychiatric disorders in adulthood. This article reviews preclinical…”
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Pendrin localizes to the adrenal medulla and modulates catecholamine release by Lazo-Fernandez, Yoskaly, Aguilera, Greti, Pham, Truyen D, Park, Annie Y, Beierwaltes, William H, Sutliff, Roy L, Verlander, Jill W, Pacak, Karel, Osunkoya, Adeboye O, Ellis, Carla L, Kim, Young Hee, Shipley, Gregory L, Wynne, Brandi M, Hoover, Robert S, Sen, Shurjo K, Plotsky, Paul M, Wall, Susan M

“…Pendrin (Slc26a4) is a Cl(-)/HCO3 (-) exchanger expressed in renal intercalated cells and mediates renal Cl(-) absorption. With pendrin gene ablation, blood…”
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Alterations in Central Neuropeptide Expression, Release, and Receptor Binding in Rats Bred for High Anxiety: Critical Role of Vasopressin by WIGGER, Alexandra, SANCHEZ, Mar M, LANDGRAF, Rainer, MATHYS, Kenneth C, EBNER, Karl, FRANK, Elisabeth, DONG LIU, KRESSE, Adelheid, NEUMANN, Inga D, HOLSBOER, Florian, PLOTSKY, Paul M

“…To model aspects of trait anxiety/depression, Wistar rats were bred for extremes in either hyper (HAB)- or hypo(LAB)-anxiety as measured on the elevated…”
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Maternal Care, Hippocampal Glucocorticoid Receptors, and Hypothalamic- Pituitary-Adrenal Responses to Stress by Liu, Dong, Diorio, Josie, Tannenbaum, Beth, Caldji, Christian, Francis, Darlene, Freedman, Alison, Sharma, Shakti, Pearson, Deborah, Plotsky, Paul M., Meaney, Michael J.

“…Variations in maternal care affect the development of individual differences in neuroendocrine responses to stress in rats. As adults, the offspring of mothers…”
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Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long–Evans rats by Kalinichev, Mikhail, Easterling, Keith W, Plotsky, Paul M, Holtzman, Stephen G

“…Early neonatal environmental factors appear to have powerful and long-lasting influences on an organism's physiology and behavior. Long–Evans male rats…”
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Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment by Huot, R L, Thrivikraman, K V, Meaney, M J, Plotsky, P M

“…This study was based on the findings of a high comorbidity among anxiety and depression as well as with alcohol abuse. To evaluate first exposure alcohol…”
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Alterations in diurnal cortisol rhythm and acoustic startle response in nonhuman primates with adverse rearing by Sánchez, Mar M., Noble, Pamela M., Lyon, Casie K., Plotsky, Paul M., Davis, Michael, Nemeroff, Charles B., Winslow, James T.

“…Early adverse experiences represent risk factors for the development of anxiety and mood disorders. Studies in nonhuman primates have largely focused on the…”
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