Search Results - "Plomann, Markus"

TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy by Zehender, Ariella, Li, Yi-Nan, Lin, Neng-Yu, Stefanica, Adrian, Nüchel, Julian, Chen, Chih-Wei, Hsu, Hsiao-Han, Zhu, Honglin, Ding, Xiao, Huang, Jingang, Shen, Lichong, Györfi, Andrea-Hermina, Soare, Alina, Rauber, Simon, Bergmann, Christina, Ramming, Andreas, Plomann, Markus, Eckes, Beate, Schett, Georg, Distler, Jörg H. W.

“…Activation of fibroblasts is essential for physiological tissue repair. Uncontrolled activation of fibroblasts, however, may lead to tissue fibrosis with organ…”
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A junctional PACSIN2/EHD4/MICAL-L1 complex coordinates VE-cadherin trafficking for endothelial migration and angiogenesis by Malinova, Tsveta S., Angulo-Urarte, Ana, Nüchel, Julian, Tauber, Marina, van der Stoel, Miesje M., Janssen, Vera, de Haan, Annett, Groenen, Anouk G., Tebbens, Merel, Graupera, Mariona, Plomann, Markus, Huveneers, Stephan

“…Angiogenic sprouting relies on collective migration and coordinated rearrangements of endothelial leader and follower cells. VE-cadherin-based adherens…”
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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress by Nüchel, Julian, Tauber, Marina, Nolte, Janica L., Mörgelin, Matthias, Türk, Clara, Eckes, Beate, Demetriades, Constantinos, Plomann, Markus

“…Cells communicate with their environment via surface proteins and secreted factors. Unconventional protein secretion (UPS) is an evolutionarily conserved…”
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PACSIN2 accelerates nephrin trafficking and is up‐regulated in diabetic kidney disease by Dumont, Vincent, Tolvanen, Tuomas A., Kuusela, Sara, Wang, Hong, Nyman, Tuula A., Lindfors, Sonja, Tienari, Jukka, Nisen, Harry, Suetsugu, Shiro, Plomann, Markus, Kawachi, Hiroshi, Lehtonen, Sanna

“…ABSTRACT Nephrin is a core component of podocyte (glomerular epithelial cell) slit diaphragm and is required for kidney ultrafiltration. Down‐regulation or…”
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Dental Pulp Inflammation Initiates the Occurrence of Mast Cells Expressing the α1 and β1 Subunits of Soluble Guanylyl Cyclase by Korkmaz, Yüksel, Plomann, Markus, Puladi, Behrus, Demirbas, Aysegül, Bloch, Wilhelm, Deschner, James

“…The binding of nitric oxide (NO) to heme in the β1 subunit of soluble guanylyl cyclase (sGC) activates both the heterodimeric α1β1 and α2β1 isoforms of the…”
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COMP-assisted collagen secretion--a novel intracellular function required for fibrosis by Schulz, Jan-Niklas, Nüchel, Julian, Niehoff, Anja, Bloch, Wilhelm, Schönborn, Katrin, Hayashi, Shujiro, Kamper, Matthias, Brinckmann, Jürgen, Plomann, Markus, Paulsson, Mats, Krieg, Thomas, Zaucke, Frank, Eckes, Beate

“…Cartilage oligomeric matrix protein (COMP) is an abundant component in the extracellular matrix (ECM) of load-bearing tissues such as tendons and cartilage. It…”
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GRASP55 regulates intra‐Golgi localization of glycosylation enzymes to control glycosphingolipid biosynthesis by Pothukuchi, Prathyush, Agliarulo, Ilenia, Pirozzi, Marinella, Rizzo, Riccardo, Russo, Domenico, Turacchio, Gabriele, Nüchel, Julian, Yang, Jia‐Shu, Gehin, Charlotte, Capolupo, Laura, Hernandez‐Corbacho, Maria Jose, Biswas, Ansuman, Vanacore, Giovanna, Dathan, Nina, Nitta, Takahiro, Henklein, Petra, Thattai, Mukund, Inokuchi, Jin‐Ichi, Hsu, Victor W, Plomann, Markus, Obeid, Lina M, Hannun, Yusuf A, Luini, Alberto, D’Angelo, Giovanni, Parashuraman, Seetharaman

“…The Golgi apparatus, the main glycosylation station of the cell, consists of a stack of discontinuous cisternae. Glycosylation enzymes are usually concentrated…”
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FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets by Begonja, Antonija Jurak, Pluthero, Fred G., Suphamungmee, Worawit, Giannini, Silvia, Christensen, Hilary, Leung, Richard, Lo, Richard W., Nakamura, Fumihiko, Lehman, William, Plomann, Markus, Hoffmeister, Karin M., Kahr, Walter H.A., Hartwig, John H., Falet, Hervé

“…Bin-Amphiphysin-Rvs (BAR) and Fes-CIP4 homology BAR (F-BAR) proteins generate tubular membrane invaginations reminiscent of the megakaryocyte (MK) demarcation…”
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PICK1 interacts with PACSIN to regulate AMPA receptor internalization and cerebellar long-term depression by Anggono, Victor, Koç-Schmitz, Yeliz, Widagdo, Jocelyn, Kormann, Jan, Quan, Annie, Chen, Chih-Ming, Robinson, Phillip J., Choi, Se-Young, Linden, David J., Plomann, Markus, Huganir, Richard L.

“…The dynamic trafficking of AMPA receptors (AMPARs) into and out of synapses is crucial for synaptic transmission, plasticity, learning, and memory. The protein…”
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GRASPing the unconventional secretory machinery to bridge cellular stress signaling to the extracellular proteome by Demetriades, Constantinos, Nüchel, Julian, Plomann, Markus

“…Cellular adaptation to stress is a crucial homeostatic process for survival, metabolism, physiology, and disease. Cells respond to stress stimuli (e.g.,…”
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EHD proteins are associated with tubular and vesicular compartments and interact with specific phospholipids by Blume, Jessica J., Halbach, Arndt, Behrendt, Dieter, Paulsson, Mats, Plomann, Markus

“…The four Eps15 homology (EH) domain-containing proteins, EHD1–EHD4, have recently been ascribed roles in the regulation of the recycling of distinct receptor…”
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ARP-T1-associated Bazex–Dupré–Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathies by Park, Hyun-Sook, Papanastasi, Eirini, Blanchard, Gabriela, Chiticariu, Elena, Bachmann, Daniel, Plomann, Markus, Morice-Picard, Fanny, Vabres, Pierre, Smahi, Asma, Huber, Marcel, Pich, Christine, Hohl, Daniel

“…Actin-Related Protein-Testis1 (ARP-T1)/ ACTRT1 gene mutations cause the Bazex-Dupré-Christol Syndrome (BDCS) characterized by follicular atrophoderma,…”
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The cytoplasmic protein Pacsin 2 in kidney development and injury repair by Yao, Gang, Luyten, Annouck, Takakura, Ayumi, Plomann, Markus, Zhou, Jing

“…The protein kinase C and casein kinase 2 substrate in neurons (Pacsin) is a subfamily of membrane-binding proteins that participates in vesicle trafficking and…”
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Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1 by Pérez-Otaño, Isabel, Ehlers, Michael D, Luján, Rafael, Tavalin, Steven J, Plomann, Markus, Modregger, Jan, Liu, Xiao-Bo, Jones, Edward G, Heinemann, Stephen F, Lo, Donald C

“…A key step in glutamatergic synapse maturation is the replacement of developmentally expressed N-methyl-D-aspartate receptors (NMDARs) with mature forms that…”
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A Hinge in the Distal End of the PACSIN 2 F-BAR Domain May Contribute to Membrane-Curvature Sensing by Plomann, Markus, Wittmann, Julia G., Rudolph, Markus G.

“…The protein kinase C and casein kinase 2 substrates in neurons (PACSINs) represent a subfamily of membrane-binding proteins characterized by an amino-terminal…”
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Casein Kinase 2 Phosphorylation of Protein Kinase C and Casein Kinase 2 Substrate in Neurons (PACSIN) 1 Protein Regulates Neuronal Spine Formation by Schael, Sylvia, Nüchel, Julian, Müller, Stefan, Petermann, Philipp, Kormann, Jan, Pérez-Otaño, Isabel, Martínez, Sonia Marco, Paulsson, Mats, Plomann, Markus

“…The PACSIN (protein kinase C and casein kinase 2 substrate in neurons) adapter proteins couple components of the clathrin-mediated endocytosis machinery with…”
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Fibroblasts in Mechanically Stressed Collagen Lattices Assume a “Synthetic” Phenotype by Kessler, Daniela, Dethlefsen, Silke, Haase, Ingo, Plomann, Markus, Hirche, Frank, Krieg, Thomas, Eckes, Beate

“…Fibroblasts are subjected to changes of the mechanical force balance during physiological as well as pathological situations, such as wound healing,…”
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Loss of SNAP-25 and rabphilin 3a in sensory-motor cortex in Huntington's disease by Smith, Ruben, Klein, Pontus, Koc-Schmitz, Yeliz, Waldvogel, Henry J, Faull, Richard L.M, Brundin, Patrik, Plomann, Markus, Li, Jia-Yi

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG-expansion in the gene encoding the protein huntingtin. The…”
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PACSIN 2 represses cellular migration through direct association with cyclin D1 but not its alternate splice form cyclin D1b by Meng, Hui, Tian, Lifeng, Zhou, Jie, Li, Zhiping, Jiao, Xuanmao, Li, Wayne W., Plomann, Markus, Xu, Zhishun, Lisanti, Michael P., Wang, Chenguang, Pestell, Richard G

“…Cyclin D1 overexpression is a common feature of many human malignancies. Genomic deletion analysis has demonstrated a key role for cyclin D1 in cellular…”
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Identification of neuronal substrates implicates Pak5 in synaptic vesicle trafficking by Strochlic, Todd I, Concilio, Susanna, Viaud, Julien, Eberwine, Ryan A, Wong, Lisa Epstein, Minden, Audrey, Turk, Benjamin E, Plomann, Markus, Peterson, Jeffrey R

“…Synaptic transmission is mediated by a complex set of molecular events that must be coordinated in time and space. While many proteins that function at the…”
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