Search Results - "Plog, Benjamin"

The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future by Plog, Benjamin A, Nedergaard, Maiken

“…The central nervous system (CNS) is unique in being the only organ system lacking lymphatic vessels to assist in the removal of interstitial metabolic waste…”
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Understanding the functions and relationships of the glymphatic system and meningeal lymphatics by Louveau, Antoine, Plog, Benjamin A, Antila, Salli, Alitalo, Kari, Nedergaard, Maiken, Kipnis, Jonathan

“…Recent discoveries of the glymphatic system and of meningeal lymphatic vessels have generated a lot of excitement, along with some degree of skepticism. Here,…”
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Impairment of glymphatic pathway function promotes tau pathology after traumatic brain injury by Iliff, Jeffrey J, Chen, Michael J, Plog, Benjamin A, Zeppenfeld, Douglas M, Soltero, Melissa, Yang, Lijun, Singh, Itender, Deane, Rashid, Nedergaard, Maiken

“…Traumatic brain injury (TBI) is an established risk factor for the early development of dementia, including Alzheimer's disease, and the post-traumatic brain…”
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Cerebral arterial pulsation drives paravascular CSF-interstitial fluid exchange in the murine brain by Iliff, Jeffrey J, Wang, Minghuan, Zeppenfeld, Douglas M, Venkataraman, Arun, Plog, Benjamin A, Liao, Yonghong, Deane, Rashid, Nedergaard, Maiken

“…CSF from the subarachnoid space moves rapidly into the brain along paravascular routes surrounding penetrating cerebral arteries, exchanging with brain…”
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Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system by Plog, Benjamin A, Dashnaw, Matthew L, Hitomi, Emi, Peng, Weiguo, Liao, Yonghong, Lou, Nanhong, Deane, Rashid, Nedergaard, Maiken

“…The nonspecific and variable presentation of traumatic brain injury (TBI) has motivated an intense search for blood-based biomarkers that can objectively…”
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Impairment of paravascular clearance pathways in the aging brain by Kress, Benjamin T., Iliff, Jeffrey J., Xia, Maosheng, Wang, Minghuan, Wei, Helen S., Zeppenfeld, Douglas, Xie, Lulu, Kang, Hongyi, Xu, Qiwu, Liew, Jason A., Plog, Benjamin A., Ding, Fengfei, Deane, Rashid, Nedergaard, Maiken

“…Objective In the brain, protein waste removal is partly performed by paravascular pathways that facilitate convective exchange of water and soluble contents…”
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Aquaporin-4-dependent glymphatic solute transport in the rodent brain by Mestre, Humberto, Hablitz, Lauren M, Xavier, Anna Lr, Feng, Weixi, Zou, Wenyan, Pu, Tinglin, Monai, Hiromu, Murlidharan, Giridhar, Castellanos Rivera, Ruth M, Simon, Matthew J, Pike, Martin M, Plá, Virginia, Du, Ting, Kress, Benjamin T, Wang, Xiaowen, Plog, Benjamin A, Thrane, Alexander S, Lundgaard, Iben, Abe, Yoichiro, Yasui, Masato, Thomas, John H, Xiao, Ming, Hirase, Hajime, Asokan, Aravind, Iliff, Jeffrey J, Nedergaard, Maiken

“…The glymphatic system is a brain-wide clearance pathway; its impairment contributes to the accumulation of amyloid-β. Influx of cerebrospinal fluid (CSF)…”
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When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow by Plog, Benjamin A, Lou, Nanhong, Pierre, Clifford A, Cove, Alex, Kenney, H Mark, Hitomi, Emi, Kang, Hongyi, Iliff, Jeffrey J, Zeppenfeld, Douglas M, Nedergaard, Maiken, Vates, G Edward

“…Cranial neurosurgical procedures can cause changes in brain function. There are many potential explanations, but the effect of simply opening the skull has not…”
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The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathy by Petraglia, Anthony L, Plog, Benjamin A, Dayawansa, Samantha, Chen, Michael, Dashnaw, Matthew L, Czerniecka, Katarzyna, Walker, Corey T, Viterise, Tyler, Hyrien, Ollivier, Iliff, Jeffrey J, Deane, Rashid, Nedergaard, Maiken, Huang, Jason H

“…There has been an increased focus on the neurological sequelae of repetitive mild traumatic brain injury (TBI), particularly neurodegenerative syndromes, such…”
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Paravascular microcirculation facilitates rapid lipid transport and astrocyte signaling in the brain by Thrane, Vinita Rangroo, Thrane, Alexander S., Plog, Benjamin A., Thiyagarajan, Meenakshisundaram, Iliff, Jeffrey J., Deane, Rashid, Nagelhus, Erlend A., Nedergaard, Maiken

“…In the brain, a paravascular space exists between vascular cells and astroglial end-foot processes, creating a continuous sheath surrounding blood vessels…”
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Filtering the muddied waters of brain edema by Thrane, Alexander S., Rangroo Thrane, Vinita, Plog, Benjamin A., Nedergaard, Maiken

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Why have we not yet developed a simple blood test for TBI? by Plog, Benjamin A, Nedergaard, Maiken

“…In recent years, traumatic brain injury (TBI) has emerged as a rapidly growing public health challenge. Annually, approximately 1.7 million people will sustain…”
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The pathophysiology underlying repetitive mild traumatic brain injury in a novel mouse model of chronic traumatic encephalopathy by Petraglia, AnthonyL, Plog, BenjaminA, Dayawansa, Samantha, Dashnaw, MatthewL, Czerniecka, Katarzyna, Walker, CoreyT, Chen, Michael, Hyrien, Ollivier, Iliff, JeffreyJ, Deane, Rashid, Huang, JasonH, Nedergaard, Maiken

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Restorative Treatments for Cervical Spinal Cord Injury, a Narrative Review by Kaleem, Muhammad I, Javeed, Saad, Plog, Benjamin A, Gupta, Vivek P, Ray, Wilson Z

“…A narrative review. To summarize relevant data from representative studies investigating upper limb restorative therapies for cervical spinal cord injury…”
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Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain by Plog, Benjamin A, Mestre, Humberto, Olveda, Genaro E, Sweeney, Amanda M, Kenney, H Mark, Cove, Alexander, Dholakia, Kosha Y, Tithof, Jeffrey, Nevins, Thomas D, Lundgaard, Iben, Du, Ting, Kelley, Douglas H, Nedergaard, Maiken

“…Despite the initial promise of immunotherapy for CNS disease, multiple recent clinical trials have failed. This may be due in part to characteristically low…”
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A novel technique for morphometric quantification of subarachnoid hemorrhage-induced microglia activation by Plog, Benjamin A., Moll, Katherine M., Kang, Hongyi, Iliff, Jeffrey J., Dashnaw, Matthew L., Nedergaard, Maiken, Vates, G. Edward

“…•Development of a novel morphometric analysis to quantify microglia activation following SAH.•This analysis revealed a decrease in microglial process…”
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Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain by Plog, Benjamin A, Mestre, Humberto, Olveda, Genaro E, Sweeney, Amanda M, Kenney, H Mark, Cove, Alexander, Dholakia, Kosha Y, Tithof, Jeffrey, Nevins, Thomas D, Lundgaard, Iben, Du, Ting, Kelley, Douglas H, Nedergaard, Maiken

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Neurologic injury in snowmobiling by Plog, BenjaminA, Pierre, CliffordA, Srinivasan, Vasisht, Srinivasan, Kaushik, Petraglia, AnthonyL, Huang, JasonH

“…Background: Snowmobiles are increasingly popular recreational, all-terrain utility vehicles that require skill and physical strength to operate given their…”
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Tree stand falls: A persistent cause of neurological injury in hunting by Pierre, Clifford A, Plog, Benjamin A, Srinivasan, Vasisht, Srinivasan, Kaushik, Petraglia, Anthony L, Huang, Jason H

“…To characterize and compare our current series of patients to prior reports in order to identify any changes in the incidence of neurological injury related to…”
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The glymphatic system in CNS health and disease: past, present and future by Plog, Benjamin A., Nedergaard, Maiken

“…The central nervous system (CNS) is unique in being the only organ system lacking lymphatic vessels to assist in the removal of interstitial metabolic waste…”
Get full text