Search Results - "Ploegh, H."

Nanobodies as non-invasive imaging tools by Rashidian, M., Ploegh, H.

“…Antibodies and antibody fragments have found wide application for therapeutic and diagnostic purposes. Single-domain antibody fragments, also known as…”
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Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction by WIERTZ, E. J. H, TORTORELLA, D, BOGYO, M, YU, J, MOTHES, W, JONES, T. R, RAPOPORT, T. A, PLOEGH, H. L

“…The human cytomegalovirus genome encodes proteins that trigger destruction of newly synthesized major histocompatibility complex (MHC) class I molecules. The…”
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Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity by Walters, B.J., Campbell, S.L., Chen, P.C., Taylor, A.P., Schroeder, D.G., Dobrunz, L.E., Artavanis-Tsakonas, K., Ploegh, H.L., Wilson, J.A., Cox, G.A., Wilson, S.M.

“…The ubiquitin proteasome pathway has been implicated in the pathogenesis of many neurodegenerative diseases, and alterations in two different deubiquitinating…”
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Viral Strategies of Immune Evasion by Ploegh, Hidde L.

“…The vertebrate body is an ideal breeding ground for viruses and provides the conditions that promote their growth, survival, and transmission. The immune…”
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A proteolytic system that compensates for loss of proteasome function by Ploegh, Hidde L, Glas, Rickard, Bogyo, Matthew, McMaster, John S, Gaczynska, Maria

“…Proteolysis is essential for the execution of many cellular functions. These include removal of incorrectly folded or damaged proteins, the activation of…”
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Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol by Shamu, C E, Flierman, D, Ploegh, H L, Rapoport, T A, Chau, V

“…The human cytomegalovirus protein US11 induces the dislocation of MHC class I heavy chains from the endoplasmic reticulum (ER) into the cytosol for degradation…”
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Isolation and characterization of the intracellular MHC class II compartment by Tulp, Abraham, Verwoerd, Desirée, Dobberstein, Bernhard, Ploegh, Hidde L, Pieters, Jean

“…An intracellular compartment has been isolated to which MHC class II molecules are transported on their way to the plasma membrane. They arrive with an…”
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TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells by Van Kaer, L, Ashton-Rickardt, P G, Ploegh, H L, Tonegawa, S

“…The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for a transporter, presumed to be involved in the delivery of peptides…”
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T-cell engagement of dendritic cells rapidly rearranges MHC class II transport by Ploegh, Hidde L, Boes, Marianne, Cerny, Jan, Massol, Ramiro, Op den Brouw, Marjolein, Kirchhausen, Tom, Chen, Jianzhu

“…Assembly of major histocompatibility complex (MHC) molecules, which present antigen in the form of short peptides to T lymphocytes, occurs in the endoplasmic…”
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Human Cytomegalovirus US3 Impairs Transport and Maturation of Major Histocompatibility Complex Class I Heavy Chains by Jones, Thomas R., Emmanuel J. H. J. Wiertz, Sun, Lei, Fish, Kenneth N., Nelson, Jay A., Ploegh, Hidde L.

“…The human cytomegalovirus (HCMV) early glycoprotein products of the US11 and US2 open reading frames cause increased turnover of major histocompatibility…”
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Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas by CROMME, F. V, AIREY, J, HEEMELS, M.-T, PLOEGH, H. L, KEATING, P. J, STERN, P. L, MEIJER, C. J. L. M, WALBOOMERS, J. M. M

“…Malignant tumor cells can escape CD8+ cytotoxic T cell killing by downregulating class I major histocompatibility complex (MHC) expression. Stable class I MHC…”
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A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14 by Borodovsky, Anna, Kessler, Benedikt M., Casagrande, Rocco, Overkleeft, Herman S., Wilkinson, Keith D., Ploegh, Hidde L.

“…A C‐terminally modified ubiquitin (Ub) derivative, ubiquitin vinyl sulfone (UbVS), was synthesized as an active site‐directed probe that irreversibly modifies…”
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A role for N-glycanase in the cytosolic turnover of glycoproteins by Hirsch, Christian, Blom, Daniël, Ploegh, Hidde L.

“…Successful maturation determines the intracellular fate of secretory and membrane proteins in the endoplasmic reticulum (ER). Failure of proteins to fold or…”
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Human Cytomegalovirus Open Reading Frame TRL11/IRL11 Encodes an Immunoglobulin G Fc-Binding Protein by Lilley, B N, Ploegh, H L, Tirabassi, R S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Varicella-Zoster Virus Retains Major Histocompatibility Complex Class I Proteins in the Golgi Compartment of Infected Cells by Abendroth, A, Lin, I, Slobedman, B, Ploegh, H, Arvin, A M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Viral Subversion of the Immune System by Tortorella, Domenico, Gewurz, Benjamin E, Furman, Margo H, Schust, Danny J, Ploegh, Hidde L

“…This review describes the diverse array of pathways and molecular targets that are used by viruses to elude immune detection and destruction. These include…”
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Neuronal Loss and Brain Atrophy in Mice Lacking Cathepsins B and L by Felbor, Ute, Kessler, Benedikt, Mothes, Walther, Goebel, Hans H., Ploegh, Hidde L., Bronson, Roderick T., Olsen, Bjorn R.

“…Cathepsins B and L are widely expressed cysteine proteases implicated in both intracellular proteolysis and extracellular matrix remodeling. However, specific…”
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Secreted cathepsin L generates endostatin from collagen XVIII by Felbor, Ute, Dreier, Lars, Bryant, Rebecca A.R., Ploegh, Hidde L., Olsen, Bjorn R., Mothes, Walther

“…Endostatin, an inhibitor of angiogenesis and tumor growth, was identified originally in conditioned media of murine hemangioendothelioma (EOMA) cells…”
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Stable binding of the herpes simplex virus ICP47 protein to the peptide binding site of TAP by Tomazin, R., Hill, A. B., Jugovic, P., York, I., Endert, P., Ploegh, H. L., Andrews, D. W., Johnson, D. C.

“…The herpes simplex virus (HSV) ICP47 protein inhibits the MHC class I antigen presentation pathway by inhibiting the transporter associated with antigen…”
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Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization by Kropshofer, Harald, Röhn, Till A, Boes, Marianne, Wolters, Dirk, Spindeldreher, Sebastian, Müller, Bernd, Langen, Hanno, Ploegh, Hidde, Vogt, Anne B

“…Dendritic cells (DCs) initiate and regulate immunity against foreign and self antigens. Here we identified more than 200 individual major histocompatibility…”
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