Search Results - "Plitas, George"

ASO Author Reflections: Clinical Importance of Histologic Subtype for Metaplastic Breast Cancer by Tadros, Audree B., Plitas, George

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Survival Outcomes for Metaplastic Breast Cancer Differ by Histologic Subtype by Tadros, Audree B., Sevilimedu, Varadan, Giri, Dilip D., Zabor, Emily C., Morrow, Monica, Plitas, George

“…Background Metaplastic breast carcinoma (MBC) is a rare, aggressive subtype of breast cancer associated with poorer overall survival than other triple-negative…”
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Pretreatment neutrophil-to-lymphocyte ratio and mutational burden as biomarkers of tumor response to immune checkpoint inhibitors by Valero, Cristina, Lee, Mark, Hoen, Douglas, Weiss, Kate, Kelly, Daniel W., Adusumilli, Prasad S., Paik, Paul K., Plitas, George, Ladanyi, Marc, Postow, Michael A., Ariyan, Charlotte E., Shoushtari, Alexander N., Balachandran, Vinod P., Hakimi, A. Ari, Crago, Aimee M., Long Roche, Kara C., Smith, J. Joshua, Ganly, Ian, Wong, Richard J., Patel, Snehal G., Shah, Jatin P., Lee, Nancy Y., Riaz, Nadeem, Wang, Jingming, Zehir, Ahmet, Berger, Michael F., Chan, Timothy A., Seshan, Venkatraman E., Morris, Luc G. T.

“…Treatment with immune checkpoint inhibitors (ICI) has demonstrated clinical benefit for a wide range of cancer types. Because only a subset of patients…”
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Reply to: Metaplastic Breast Carcinoma and Other Triple-Negative Subtype Breast Cancers: Which is the Worst? by Tadros, Audree B., Sevilimedu, Varadan, Plitas, George

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Improved prediction of immune checkpoint blockade efficacy across multiple cancer types by Chowell, Diego, Yoo, Seong-Keun, Valero, Cristina, Pastore, Alessandro, Krishna, Chirag, Lee, Mark, Hoen, Douglas, Shi, Hongyu, Kelly, Daniel W., Patel, Neal, Makarov, Vladimir, Ma, Xiaoxiao, Vuong, Lynda, Sabio, Erich Y., Weiss, Kate, Kuo, Fengshen, Lenz, Tobias L., Samstein, Robert M., Riaz, Nadeem, Adusumilli, Prasad S., Balachandran, Vinod P., Plitas, George, Ari Hakimi, A., Abdel-Wahab, Omar, Shoushtari, Alexander N., Postow, Michael A., Motzer, Robert J., Ladanyi, Marc, Zehir, Ahmet, Berger, Michael F., Gönen, Mithat, Morris, Luc G. T., Weinhold, Nils, Chan, Timothy A.

“…Only a fraction of patients with cancer respond to immune checkpoint blockade (ICB) treatment, but current decision-making procedures have limited accuracy. In…”
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Axillary Downstaging in Occult Primary Breast Cancer After Neoadjuvant Chemotherapy by Botty Van den Bruele, Astrid, Lavery, Jessica, Plitas, George, Pilewskie, Melissa L.

“…Background Neoadjuvant chemotherapy (NAC) is increasingly used for clinically node-positive (cN+) tumors with intact primary breast cancer (IPBC) to downstage…”
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Poor response to neoadjuvant chemotherapy in metaplastic breast carcinoma by Wong, Willard, Brogi, Edi, Reis-Filho, Jorge S., Plitas, George, Robson, Mark, Norton, Larry, Morrow, Monica, Wen, Hannah Y.

“…Metaplastic breast carcinoma (MpBC) is a rare special histologic subtype of breast carcinoma characterized by the presence of squamous and/or mesenchymal…”
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Enhancing mucosal immunity by transient microbiota depletion by Becattini, Simone, Littmann, Eric R., Seok, Ruth, Amoretti, Luigi, Fontana, Emily, Wright, Roberta, Gjonbalaj, Mergim, Leiner, Ingrid M., Plitas, George, Hohl, Tobias M., Pamer, Eric G.

“…Tissue resident memory CD8 +  T cells (Trm) are poised for immediate reactivation at sites of pathogen entry and provide optimal protection of mucosal…”
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Microscopic Extracapsular Extension in Sentinel Lymph Nodes Does Not Mandate Axillary Dissection in Z0011-Eligible Patients by Barrio, Andrea V., Downs-Canner, Stephanie, Edelweiss, Marcia, Van Zee, Kimberly J., Cody, Hiram S., Gemignani, Mary L., Pilewskie, Melissa L., Plitas, George, El-Tamer, Mahmoud, Kirstein, Laurie, Capko, Deborah, Patil, Sujata, Morrow, Monica

“…Background In the ACOSOG ( American College of Surgeons Oncology Group ) Z0011 trial and the AMAROS ( After Mapping of the Axilla: Radiotherapy or Surgery? )…”
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Toll‐like receptor 9 inhibition confers protection from liver ischemia–reperfusion injury by Bamboat, Zubin M., Balachandran, Vinod P., Ocuin, Lee M., Obaid, Hebroon, Plitas, George, DeMatteo, Ronald P.

“…Endogenous ligands such as high‐mobility group box 1 (HMGB1) and nucleic acids are released by dying cells and bind Toll‐like receptors (TLRs). Because TLR9…”
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Conventional DCs reduce liver ischemia/reperfusion injury in mice via IL-10 secretion by Bamboat, Zubin M, Ocuin, Lee M, Balachandran, Vinod P, Obaid, Hebroon, Plitas, George, DeMatteo, Ronald P

“…TLRs are recognized as promoters of tissue damage, even in the absence of pathogens. TLR binding to damage-associated molecular patterns (DAMPs) released by…”
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Opioids and immune checkpoint inhibitors differentially regulate a common immune network in triple-negative breast cancer by Scarpa, Joseph R., Montagna, Giacomo, Plitas, George, Gulati, Amitabh, Fischer, Gregory W., Mincer, Joshua S.

“…Background Opioids are the primary analgesics for cancer pain. Recent clinical evidence suggests opioids may counteract the effect of immune checkpoint…”
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Genetic and epigenetic variation in the lineage specification of regulatory T cells by Arvey, Aaron, van der Veeken, Joris, Plitas, George, Rich, Stephen S, Concannon, Patrick, Rudensky, Alexander Y

“…Regulatory T (Treg) cells, which suppress autoimmunity and other inflammatory states, are characterized by a distinct set of genetic elements controlling their…”
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Toll-like receptor 9 inhibition reduces mortality in polymicrobial sepsis by Plitas, George, Burt, Bryan M, Nguyen, Hoang M, Bamboat, Zubin M, DeMatteo, Ronald P

“…The high rate of mortality in patients with sepsis results from an inappropriately amplified systemic inflammatory response to infection. Toll-like receptors…”
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Neutrophil IL-10 suppresses peritoneal inflammatory monocytes during polymicrobial sepsis by Ocuin, Lee M., Bamboat, Zubin M., Balachandran, Vinod P., Cavnar, Michael J., Obaid, Hebroon, Plitas, George, DeMatteo, Ronald P.

“…Using a depleting antibody, the authors demonstrate that neutrophils are dispensable for survival in polymicrobial sepsis and regulate inflammatory monocytes…”
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Vancomycin-resistant enterococci exploit antibiotic-induced innate immune deficits by BRANDL, Katharina, PLITAS, George, MIHU, Coralia N, UBEDA, Carles, TING JIA, FLEISHER, Martin, SCHNABL, Bernd, DEMATTEO, Ronald P, PAMER, Eric G

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Preoperative immune checkpoint inhibition and cryoablation in early-stage breast cancer by Comen, Elizabeth, Budhu, Sadna, Elhanati, Yuval, Page, David, Rasalan-Ho, Teresa, Ritter, Erika, Wong, Phillip, Plitas, George, Patil, Sujata, Brogi, Edi, Jochelson, Maxine, Bryce, Yolanda, Solomon, Stephen B., Norton, Larry, Merghoub, Taha, McArthur, Heather L.

“…Local cryoablation can engender systemic immune activation/anticancer responses in tumors otherwise resistant to immune checkpoint blockade (ICB). We evaluated…”
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Tumor resident regulatory T cells by Glasner, Ariella, Plitas, George

“…The immune system mediates powerful effector mechanisms to protect against a diversity of pathogens and equally as important regulatory functions, to limit…”
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NK Dendritic Cells Are Innate Immune Responders to Listeria monocytogenes Infection by Plitas, George, Chaudhry, Umer I, Kingham, T. Peter, Raab, Jesse R, DeMatteo, Ronald P

“…NK dendritic cells (NKDC) are recently described immunologic cells that possess both lytic and Ag-presenting function and produce prolific quantities of…”
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CD11c identifies a subset of murine liver natural killer cells that responds to adenoviral hepatitis by Burt, Bryan M., Plitas, George, Stableford, Jennifer A., Nguyen, Hoang M., Bamboat, Zubin M., Pillarisetty, Venu G., DeMatteo, Ronald P.

“…The liver contains a unique repertoire of immune cells and a particular abundance of NK cells. We have found that CD11c defines a distinct subset of NK cells…”
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