Search Results - "Plieth, David"
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Contribution of Epithelial-derived Fibroblasts to Bleomycin-induced Lung Fibrosis
Published in American journal of respiratory and critical care medicine (01-10-2009)“…Lung fibroblasts are key mediators of fibrosis resulting in accumulation of excessive interstitial collagen and extracellular matrix, but their origins are not…”
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A proximal activator of transcription in epithelial-mesenchymal transition
Published in The Journal of clinical investigation (01-02-2007)“…Epithelial-mesenchymal transition (EMT) is an important mechanism for phenotypic conversion in normal development and disease states such as tissue fibrosis…”
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Transcriptional networks in epithelial-mesenchymal transition
Published in PloS one (30-09-2011)“…Epithelial-mesenchymal transition (EMT) changes polarized epithelial cells into migratory phenotypes associated with loss of cell-cell adhesion molecules and…”
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Characterization of Fibroblast-specific Protein 1 in Pulmonary Fibrosis
Published in American journal of respiratory and critical care medicine (15-04-2005)“…Because fibroblasts produce collagen and other extracellular matrix components that are deposited during tissue fibrosis, defining the behavior of these cells…”
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Conditional Abatement of Tissue Fibrosis Using Nucleoside Analogs to Selectively Corrupt DNA Replication in Transgenic Fibroblasts
Published in Molecular therapy (01-02-2001)“…Progressive tissue fibrosis can compromise epithelial function resulting in organ failure. Appreciating evidence suggests that fibroblasts provide fibrogenic…”
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Evidence that fibroblasts derive from epithelium during tissue fibrosis
Published in The Journal of clinical investigation (01-08-2002)“…Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver. While some view fibroblasts in adult tissues as nothing…”
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EGFR Signaling Promotes TGFβ-Dependent Renal Fibrosis
Published in Journal of the American Society of Nephrology (01-02-2012)“…The mechanisms by which angiotensin II (Ang II) promotes renal fibrosis remain incompletely understood. Ang II both stimulates TGFβ signaling and activates the…”
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TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Published in Science (American Association for the Advancement of Science) (06-02-2004)“…Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor–β (TGF-β) signaling in…”
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TGF-β Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia
Published in Science (American Association for the Advancement of Science) (06-02-2004)“…Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth$factor-\beta$($TGF-\beta$)…”
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The gatekeeper effect of epithelial-mesenchymal transition regulates the frequency of breast cancer metastasis
Published in Cancer research (Chicago, Ill.) (15-06-2003)“…When carcinoma cells metastasize, they change their phenotype to enhance motility. Cells making this switch selectively express S100A4, a p53-associated,…”
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Antibodies against macrophages that overlap in specificity with fibroblasts
Published in Kidney international (01-06-2005)“…Antibodies against macrophages that overlap in specificity with fibroblasts. Fibroblasts can be misidentified as macrophages because both cell types share…”
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Phosphatidylinositol 3-kinase signaling determines kidney size
Published in The Journal of clinical investigation (01-06-2015)“…Kidney size adaptively increases as mammals grow and in response to the loss of 1 kidney. It is not clear how kidneys size themselves or if the processes that…”
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Detection of human papillomavirus in squamous neoplasm of the penis
Published in The Journal of urology (01-02-1992)“…Infection of the external human urogenital system with human papillomavirus has been implicated with the development of genital cancer. A modified polymerase…”
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TECHNICAL NOTE: Antibodies against macrophages that overlap in specificity with fibroblasts
Published in Kidney international (01-06-2005)“…Background. Fibroblasts can be misidentified as macrophages because both cell types share antigens that are associated with popular antibodies targeting the…”
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Evidence that fibroblasts derive from epithelium during tissue fibrosis
Published in The Journal of clinical investigation (01-08-2002)“…Interstitial fibroblasts are principal effector cells of organ fibrosis in kidneys, lungs, and liver. While some view fibroblasts in adult tissues as nothing…”
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TGF-[beta] signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
Published in Science (American Association for the Advancement of Science) (06-02-2004)“…Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor-[beta] (TGF-[beta])…”
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