Search Results - "Pletnikova, O."

Alpha-2 macroglobulin in Alzheimer’s disease: a marker of neuronal injury through the RCAN1 pathway by Varma, V R, Varma, S, An, Y, Hohman, T J, Seddighi, S, Casanova, R, Beri, A, Dammer, E B, Seyfried, N T, Pletnikova, O, Moghekar, A, Wilson, M R, Lah, J J, O'Brien, R J, Levey, A I, Troncoso, J C, Albert, M S, Thambisetty, M

“…Preclinical changes that precede the onset of symptoms and eventual diagnosis of Alzheimer’s disease (AD) are a target for potential preventive interventions…”
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The Nun Study: Clinically silent AD, neuronal hypertrophy, and linguistic skills in early life by IACONO, D, MARKESBERY, W. R, GROSS, M, PLETNIKOVA, O, RUDOW, G, ZANDI, P, TRONCOSO, J. C

“…It is common to find substantial Alzheimer disease (AD) lesions, i.e., neuritic beta-amyloid plaques and neurofibrillary tangles, in the autopsied brains of…”
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Neurodegenerative phenotypes in an A53T  -synuclein transgenic mouse model are independent of LRRK2 by Daher, J. P. L., Pletnikova, O., Biskup, S., Musso, A., Gellhaar, S., Galter, D., Troncoso, J. C., Lee, M. K., Dawson, T. M., Dawson, V. L., Moore, D. J.

“…Mutations in the genes encoding LRRK2 and alpha -synuclein cause autosomal dominant forms of familial Parkinson's disease (PD). Fibrillar forms of alpha…”
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Most cases of dementia with hippocampal sclerosis may represent frontotemporal dementia by HATANPAA, K. J, BLASS, D. M, PLETNIKOVA, O, CRAIN, B. J, BIGIO, E. H, HEDREEN, J. C, WHITE, C. L, TRONCOSO, J. C

“…Hippocampal sclerosis dementia (HSD) is a disease of unknown etiology and pathogenesis. To determine whether HSD cases could be reclassified as variants of…”
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Age and gender-dependent alternative splicing of P/Q-type calcium channel EF-hand by Chang, S.Y, Yong, T.F, Yu, C.Y, Liang, M.C, Pletnikova, O, Troncoso, J, Burgunder, J.-M, Soong, T.W

“…Abstract Cav 2.1 Ca2+ channels (P/Q-type), which participate in various key roles in the CNS by mediating calcium influx, are extensively spliced. One of its…”
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Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study by Guerreiro, Rita, Ross, Owen A, Kun-Rodrigues, Celia, Hernandez, Dena G, Orme, Tatiana, Eicher, John D, Shepherd, Claire E, Parkkinen, Laura, Darwent, Lee, Heckman, Michael G, Scholz, Sonja W, Troncoso, Juan C, Pletnikova, Olga, Ansorge, Olaf, Clarimon, Jordi, Lleo, Alberto, Morenas-Rodriguez, Estrella, Clark, Lorraine, Honig, Lawrence S, Marder, Karen, Lemstra, Afina, Rogaeva, Ekaterina, St George-Hyslop, Peter, Londos, Elisabet, Zetterberg, Henrik, Barber, Imelda, Braae, Anne, Brown, Kristelle, Morgan, Kevin, Troakes, Claire, Al-Sarraj, Safa, Lashley, Tammaryn, Holton, Janice, Compta, Yaroslau, Van Deerlin, Vivianna, Serrano, Geidy E, Beach, Thomas G, Lesage, Suzanne, Galasko, Douglas, Masliah, Eliezer, Santana, Isabel, Pastor, Pau, Diez-Fairen, Monica, Aguilar, Miquel, Tienari, Pentti J, Myllykangas, Liisa, Oinas, Minna, Revesz, Tamas, Lees, Andrew, Boeve, Brad F, Petersen, Ronald C, Ferman, Tanis J, Escott-Price, Valentina, Graff-Radford, Neill, Cairns, Nigel J, Morris, John C, Pickering-Brown, Stuart, Mann, David, Halliday, Glenda M, Hardy, John, Trojanowski, John Q, Dickson, Dennis W, Singleton, Andrew, Stone, David J, Bras, Jose

“…Dementia with Lewy bodies is the second most common form of dementia in elderly people but has been overshadowed in the research field, partly because of…”
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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity by van der Lee, Sven J., Conway, Olivia J., Jansen, Iris, Carrasquillo, Minerva M., Kleineidam, Luca, van den Akker, Erik, Hernández, Isabel, van Eijk, Kristel R., Stringa, Najada, Chen, Jason A., Zettergren, Anna, Andlauer, Till F. M., Diez-Fairen, Monica, Simon-Sanchez, Javier, Lleó, Alberto, Zetterberg, Henrik, Nygaard, Marianne, Blauwendraat, Cornelis, Savage, Jeanne E., Mengel-From, Jonas, Moreno-Grau, Sonia, Wagner, Michael, Fortea, Juan, Keogh, Michael J., Blennow, Kaj, Skoog, Ingmar, Friese, Manuel A., Pletnikova, Olga, Zulaica, Miren, Lage, Carmen, de Rojas, Itziar, Riedel-Heller, Steffi, Illán-Gala, Ignacio, Wei, Wei, Jeune, Bernard, Orellana, Adelina, Then Bergh, Florian, Wang, Xue, Hulsman, Marc, Beker, Nina, Tesi, Niccolo, Morris, Christopher M., Indakoetxea, Begoña, Collij, Lyduine E., Scherer, Martin, Morenas-Rodríguez, Estrella, Ironside, James W., van Berckel, Bart N. M., Wiendl, Heinz, Strickland, Samantha L., Pastor, Pau, Rodríguez Rodríguez, Eloy, Boeve, Bradley F., Petersen, Ronald C., Ferman, Tanis J., van Gerpen, Jay A., Reinders, Marcel J. T., Uitti, Ryan J., Tárraga, Lluís, Maier, Wolfgang, Dols-Icardo, Oriol, Kawalia, Amit, Dalmasso, Maria Carolina, Boada, Mercè, Zettl, Uwe K., van Schoor, Natasja M., Beekman, Marian, Allen, Mariet, Masliah, Eliezer, de Munain, Adolfo López, Pantelyat, Alexander, Wszolek, Zbigniew K., Ross, Owen A., Dickson, Dennis W., Graff-Radford, Neill R., Knopman, David, Rademakers, Rosa, Lemstra, Afina W., Pijnenburg, Yolande A. L., Scheltens, Philip, Gasser, Thomas, Chinnery, Patrick F, Hemmer, Bernhard, Huisman, Martijn A., Troncoso, Juan, Moreno, Fermin, Nohr, Ellen A., Sørensen, Thorkild I. A., Heutink, Peter, Sánchez-Juan, Pascual, Posthuma, Danielle, Clarimón, Jordi, Christensen, Kaare, Ertekin-Taner, Nilüfer, Scholz, Sonja W., Ramirez, Alfredo, Ruiz, Agustín, Slagboom, Eline, van der Flier, Wiesje M., Holstege, Henne

“…The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in…”
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The new neurobiology of dementia by Thambisetty, M., Varma, V., An, Y., Mahajan, U., Oommen, A., Varma, S., Troncoso, J., Pletnikova, O., Legido-Quigley, C.

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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2 by Ramonet, David, Daher, João Paulo L, Lin, Brian M, Stafa, Klodjan, Kim, Jaekwang, Banerjee, Rebecca, Westerlund, Marie, Pletnikova, Olga, Glauser, Liliane, Yang, Lichuan, Liu, Ying, Swing, Deborah A, Beal, M Flint, Troncoso, Juan C, McCaffery, J Michael, Jenkins, Nancy A, Copeland, Neal G, Galter, Dagmar, Thomas, Bobby, Lee, Michael K, Dawson, Ted M, Dawson, Valina L, Moore, Darren J

“…Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to…”
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S-Nitrosylation of Parkin Regulates Ubiquitination and Compromises Parkin's Protective Function by Kenny K. K. Chung, Thomas, Bobby, Li, Xiaojie, Pletnikova, Olga, Troncoso, Juan C., Marsh, Laura, Dawson, Valina L., Dawson, Ted M.

“…Parkin is an E3 ubiquitin ligase involved in the ubiquitination of proteins that are important in the survival of dopamine neurons in Parkinson's disease (PD)…”
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Aggregation Promoting C-Terminal Truncation of α-Synuclein Is a Normal Cellular Process and Is Enhanced by the Familial Parkinson's Disease-Linked Mutations by Li, Wenxue, West, Neva, Colla, Emanuela, Pletnikova, Olga, Troncoso, Juan C., Marsh, Laura, Dawson, Ted M., Jäkälä, Pekka, Hartmann, Tobias, Price, Donald L., Lee, Michael K., Snyder, Solomon H.

“…Abnormal biology of α-synuclein (α-Syn) is directly implicated in the pathogenesis of Parkinson's disease and other α-synucleinopathies. Herein, we demonstrate…”
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Heritability and genetic variance of dementia with Lewy bodies by Guerreiro, Rita, Escott-Price, Valentina, Hernandez, Dena G., Kun-Rodrigues, Celia, Ross, Owen A., Orme, Tatiana, Neto, Joao Luis, Carmona, Susana, Dehghani, Nadia, Eicher, John D., Shepherd, Claire, Parkkinen, Laura, Darwent, Lee, Heckman, Michael G., Scholz, Sonja W., Troncoso, Juan C., Pletnikova, Olga, Dawson, Ted, Rosenthal, Liana, Ansorge, Olaf, Clarimon, Jordi, Lleo, Alberto, Morenas-Rodriguez, Estrella, Clark, Lorraine, Honig, Lawrence S., Marder, Karen, Lemstra, Afina, Rogaeva, Ekaterina, St. George-Hyslop, Peter, Londos, Elisabet, Zetterberg, Henrik, Barber, Imelda, Braae, Anne, Brown, Kristelle, Morgan, Kevin, Troakes, Claire, Al-Sarraj, Safa, Lashley, Tammaryn, Holton, Janice, Compta, Yaroslau, Van Deerlin, Vivianna, Serrano, Geidy E., Beach, Thomas G., Lesage, Suzanne, Galasko, Douglas, Masliah, Eliezer, Santana, Isabel, Pastor, Pau, Diez-Fairen, Monica, Aguilar, Miquel, Tienari, Pentti J., Myllykangas, Liisa, Oinas, Minna, Revesz, Tamas, Lees, Andrew, Boeve, Brad F., Petersen, Ronald C., Ferman, Tanis J., Graff-Radford, Neill, Cairns, Nigel J., Morris, John C., Pickering-Brown, Stuart, Mann, David, Halliday, Glenda M., Hardy, John, Trojanowski, John Q., Dickson, Dennis W., Singleton, Andrew, Stone, David J., Bras, Jose

“…Recent large-scale genetic studies have allowed for the first glimpse of the effects of common genetic variability in dementia with Lewy bodies (DLB),…”
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Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2 by DAHER, Joao Paulo L, PLETNIKOVA, Olga, MOORE, Darren J, BISKUP, Saskia, MUSSO, Alessandra, GELLHAAR, Sandra, GALTER, Dagmar, TRONCOSO, Juan C, LEE, Michael K, DAWSON, Ted M, DAWSON, Valina L

“…Mutations in the genes encoding LRRK2 and α-synuclein cause autosomal dominant forms of familial Parkinson's disease (PD). Fibrillar forms of α-synuclein are a…”
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Neuronal Hypertrophy in Asymptomatic Alzheimer Disease by Iacono, Diego, O'Brien, Richard, Resnick, Susan M, Zonderman, Alan B, Pletnikova, Olga, Rudow, Gay, An, Yang, West, Mark J, Crain, Barbara, Troncoso, Juan C

“…The pathologic changes of Alzheimer disease (AD) evolve very gradually over decades before the disease becomes clinically manifest. Thus, it is not uncommon to…”
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A comprehensive screening of copy number variability in dementia with Lewy bodies by Kun-Rodrigues, Celia, Orme, Tatiana, Carmona, Susana, Hernandez, Dena G., Ross, Owen A., Eicher, John D., Shepherd, Claire, Parkkinen, Laura, Darwent, Lee, Heckman, Michael G., Scholz, Sonja W., Troncoso, Juan C., Pletnikova, Olga, Dawson, Ted, Rosenthal, Liana, Ansorge, Olaf, Clarimon, Jordi, Lleo, Alberto, Morenas-Rodriguez, Estrella, Clark, Lorraine, Honig, Lawrence S., Marder, Karen, Lemstra, Afina, Rogaeva, Ekaterina, St. George-Hyslop, Peter, Londos, Elisabet, Zetterberg, Henrik, Barber, Imelda, Braae, Anne, Brown, Kristelle, Morgan, Kevin, Troakes, Claire, Al-Sarraj, Safa, Lashley, Tammaryn, Holton, Janice, Compta, Yaroslau, Van Deerlin, Vivianna, Serrano, Geidy E., Beach, Thomas G., Lesage, Suzanne, Galasko, Douglas, Masliah, Eliezer, Santana, Isabel, Pastor, Pau, Diez-Fairen, Monica, Aguilar, Miquel, Tienari, Pentti J., Myllykangas, Liisa, Oinas, Minna, Revesz, Tamas, Lees, Andrew, Boeve, Brad F., Petersen, Ronald C., Ferman, Tanis J., Escott-Price, Valentina, Graff-Radford, Neill, Cairns, Nigel J., Morris, John C., Pickering-Brown, Stuart, Mann, David, Halliday, Glenda M., Hardy, John, Trojanowski, John Q., Dickson, Dennis W., Singleton, Andrew, Stone, David J., Guerreiro, Rita, Bras, Jose

“…The role of genetic variability in dementia with Lewy bodies (DLB) is now indisputable; however, data regarding copy number variation (CNV) in this disease has…”
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Aβ deposition is associated with enhanced cortical α-synuclein lesions in Lewy body diseases by Pletnikova, Olga, West, Neva, Lee, Michael K., Rudow, Gay L., Skolasky, Richard L., Dawson, Ted M., Marsh, Laura, Troncoso, Juan C.

“…In order to understand better the neuropathological substrate of dementia in Parkinson's disease (PD) and to examine its interactions with Alzheimer's disease…”
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Regulation of work-related and occupational impacts on workers employed at railroads: experience gained in Russia and other countries by Loginova, V.A., Kas'kov, Yu.N., Zhidkova, E.A., Gurevich, K.G., Smertina, Yu.L., Pletnikova, O.A.

“…The present research is vital as it will allow increasing safety of working conditions for workers employed at railway transport due to reducing impacts…”
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Accumulation of the Authentic Parkin Substrate Aminoacyl-tRNA Synthetase Cofactor, p38/JTV-1, Leads to Catecholaminergic Cell Death by Ko, Han Seok, von Coelln, Rainer, Sriram, Sathya R, Kim, Seong Who, Chung, Kenny K. K, Pletnikova, Olga, Troncoso, Juan, Johnson, Brett, Saffary, Roya, Goh, Eyleen L, Song, Hongjun, Park, Bum-Joon, Kim, Min Jung, Kim, Sunghoon, Dawson, Valina L, Dawson, Ted M

“…Autosomal-recessive juvenile parkinsonism (AR-JP) is caused by loss-of-function mutations of the parkin gene. Parkin, a RING-type E3 ubiquitin ligase, is…”
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Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function by Wang, Cheng, Ko, Han Seok, Thomas, Bobby, Tsang, Fai, Chew, Katherine C.M., Tay, Shiam-Peng, Ho, Michelle W.L., Lim, Tit-Meng, Soong, Tuck-Wah, Pletnikova, Olga, Troncoso, Juan, Dawson, Valina L., Dawson, Ted M., Lim, Kah-Leong

“…Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests that parkin expression…”
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Alpha-2 macroglobulin in Alzheimer%apos;s disease: a marker of neuronal injury through the RCAN1 pathway by Varma, V R, Varma, S, An, Y, Hohman, T J, Seddighi, S, Casanova, R, Beri, A, Dammer, E B, Seyfried, N T, Pletnikova, O, Moghekar, A, Wilson, M R, Lah, J J, O'Brien, R J, Levey, A I, Troncoso, J C, Albert, M S, Thambisetty, M

“…Preclinical changes that precede the onset of symptoms and eventual diagnosis of Alzheimer%apos;s disease (AD) are a target for potential preventive…”
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