Search Results - "Pleticha, Josef"

Future Directions in Pain Management by Pleticha, Josef, MD, Maus, Timothy P., MD, Beutler, Andreas S., MD

“…Abstract Treatment for chronic, locoregional pain ranks among the most prevalent unmet medical needs. The failure of systemic analgesic drugs, such as opioids,…”
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Preclinical Toxicity Evaluation of AAV for Pain: Evidence from Human AAV Studies and from the Pharmacology of Analgesic Drugs by Pleticha, Josef, Heilmann, Lukas F, Evans, Christopher H, Asokan, Aravind, Samulski, Richard Jude, Beutler, Andreas S

“…Gene therapy with adeno-associated virus (AAV) has advanced in the last few years from promising results in animal models to >100 clinical trials (reported or…”
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Caffeine supplementation as part of enhanced recovery after surgery pathways: a narrative review of the evidence and knowledge gaps by Pleticha, Josef, Niesen, Adam D., Kopp, Sandra L., Johnson, Rebecca L.

“…Caffeine is used daily by 85% of United States adults and caffeine withdrawal is a major cause of perioperative headache. Studies have shown that caffeine…”
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Future Directions in Pain Management: Integrating Anatomically Selective Delivery Techniques With Novel Molecularly Selective Agents by Pleticha, Josef, Maus, Timothy P, Beutler, Andreas S

“…Treatment for chronic, locoregional pain ranks among the most prevalent unmet medical needs. The failure of systemic analgesic drugs, such as opioids, is often…”
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Association of the Charcot–Marie–Tooth disease gene ARHGEF10 with paclitaxel induced peripheral neuropathy in NCCTG N08CA (Alliance) by Boora, Ganesh K, Kulkarni, Amit A, Kanwar, Rahul, Beyerlein, Peter, Qin, Rui, Banck, Michaela S, Ruddy, Kathryn J, Pleticha, Josef, Lynch, Cynthia A, Behrens, Robert J, Züchner, Stephan, Loprinzi, Charles L, Beutler, Andreas S

“…Abstract The predisposition of patients to develop polyneuropathy in response to toxic exposure may have a genetic basis. The previous study Alliance N08C1…”
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Exome-level comparison of primary well-differentiated neuroendocrine tumors and their cell lines by Boora, Ganesh K, Kanwar, Rahul, Kulkarni, Amit A, Pleticha, Josef, Ames, Matthew, Schroth, Gary, Beutler, Andreas S, Banck, Michaela S

“…Neuroendocrine cancer cell lines are used to investigate therapeutic targets in neuroendocrine tumors (NET) and have been instrumental in the design of…”
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Intraneural convection enhanced delivery of AAVrh20 for targeting primary sensory neurons by Pleticha, Josef, Jeng-Singh, Christian, Rezek, Rahaf, Zaibak, Manal, Beutler, Andreas S.

“…Gene therapy using adeno-associated virus (AAV) is an attractive strategy to treat disorders of the peripheral nervous system (PNS), such as chronic pain or…”
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Neurotoxicity to DRG neurons varies between rodent strains treated with cisplatin and bortezomib by Podratz, Jewel L, Kulkarni, Amit, Pleticha, Josef, Kanwar, Rahul, Beutler, Andreas S, Staff, Nathan P, Windebank, Anthony J

“…Abstract Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose limiting side effect that can lead to long-term morbidity. Approximately one-third…”
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Unilateral Epidural Targeting of Resiniferatoxin Induces Bilateral Neurolysis of Spinal Nociceptive Afferents by Unger, Mark D, Pleticha, Josef, Steinauer, Joanne, Kanwar, Rahul, Diehn, Felix, LaVallee, Katherine T, Banck, Michaela S, Jones, Bryan, Yaksh, Tony L, Maus, Timothy P, Beutler, Andreas S

“…Abstract Objective This study modeled image-guided epidural drug delivery to test whether intraprocedural distribution of pre-injected contrast reliably…”
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Human interleukin‐10 delivered intrathecally by self‐complementary adeno‐associated virus 8 induces xenogeneic transgene immunity without clinical neurotoxicity in swine by Unger, Mark D., Pleticha, Josef, Heilmann, Lukas F., Newman, Laura K., Maus, Timothy P., Beutler, Andreas S.

“…Introduction Intrathecal interleukin (IL)‐10 delivered by plasmid or viral gene vectors has been proposed for clinical testing because it is effective for…”
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Fatal Meningitis in Swine after Intrathecal Administration of Adeno-associated Virus Expressing Syngeneic Interleukin-10 by Unger, Mark D., Pleticha, Josef, Collins, James E., Armien, Anibal G., Brazzell, Jennifer L., Newman, Laura K., Heilmann, Lukas F., Scholz, Jodi A., Maus, Timothy P., Beutler, Andreas S.

“…Interleukin-10 (IL-10) delivered by intrathecal (i.t.) gene vectors is a candidate investigational new drug (IND) for several chronic neurological disorders…”
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Pig lumbar spine anatomy and imaging-guided lateral lumbar puncture: A new large animal model for intrathecal drug delivery by Pleticha, Josef, Maus, Timothy P., Jeng-Singh, Christian, Marsh, Michael P., Al-Saiegh, Fadi, Christner, Jodie A., Lee, Kendall H., Beutler, Andreas S.

“…•The development of a novel method for intrathecal drug administration in the pig.•CT-anatomy demonstrates constraints underlying the failure of human LP…”
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High cerebrospinal fluid levels of interleukin-10 attained by AAV in dogs by Pleticha, J, Malkmus, S A, Heilmann, L F, Veesart, S L, Rezek, R, Xu, Q, Yaksh, T L, Beutler, A S

“…Intrathecal (IT) gene transfer using adeno-associated virus (AAV) may be clinically promising as a treatment for chronic pain if it can produce sufficiently…”
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Minimally invasive convection-enhanced delivery of biologics into dorsal root ganglia: validation in the pig model and prospective modeling in humans. Technical note by Pleticha, Josef, Maus, Timothy P, Christner, Jodie A, Marsh, Michael P, Lee, Kendall H, Hooten, W Michael, Beutler, Andreas S

“…Dorsal root ganglia (DRG) are critical anatomical structures involved in nociception. Intraganglionic (IG) drug delivery is therefore an important route of…”
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Intraoperative Pulmonary Embolism: A Case Report Emphasizing the Utility of Electrocardiogram by Pleticha, Josef, Sutton, Evan M

“…Pulmonary embolism (PE) is an important cause of perioperative morbidity and mortality. In patients with suspected PE, electrocardiogram (ECG) alone is thought…”
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