Search Results - "Plenge, Robert M."

Disciplined approach to drug discovery and early development by Plenge, Robert M

“…Our modern health care system demands therapeutic interventions that improve the lives of patients. Unfortunately, decreased productivity in therapeutics…”
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Validating therapeutic targets through human genetics by Plenge, Robert M., Scolnick, Edward M., Altshuler, David

“…Key Points Existing preclinical models have a limited ability to test 'therapeutic hypotheses'; that is, whether perturbing a target in a given manner would…”
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Principal components analysis corrects for stratification in genome-wide association studies by Price, Alkes L, Patterson, Nick J, Plenge, Robert M, Weinblatt, Michael E, Shadick, Nancy A, Reich, David

“…Population stratification--allele frequency differences between cases and controls due to systematic ancestry differences-can cause spurious associations in…”
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Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis by Raychaudhuri, Soumya, Sandor, Cynthia, Stahl, Eli A, Freudenberg, Jan, Lee, Hye-Soon, Jia, Xiaoming, Alfredsson, Lars, Padyukov, Leonid, Klareskog, Lars, Worthington, Jane, Siminovitch, Katherine A, Bae, Sang-Cheol, Plenge, Robert M, Gregersen, Peter K, de Bakker, Paul I W

“…Soumya Raychaudhuri, Paul de Bakker and colleagues report fine mapping of the rheumatoid arthritis associations within the MHC by combining genome-wide SNP…”
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Defining the role of the MHC in autoimmunity: a review and pooled analysis by Fernando, Michelle M A, Stevens, Christine R, Walsh, Emily C, De Jager, Philip L, Goyette, Philippe, Plenge, Robert M, Vyse, Timothy J, Rioux, John D

“…The major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this…”
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Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts by Liao, Katherine P, Ananthakrishnan, Ashwin N, Kumar, Vishesh, Xia, Zongqi, Cagan, Andrew, Gainer, Vivian S, Goryachev, Sergey, Chen, Pei, Savova, Guergana K, Agniel, Denis, Churchill, Susanne, Lee, Jaeyoung, Murphy, Shawn N, Plenge, Robert M, Szolovits, Peter, Kohane, Isaac, Shaw, Stanley Y, Karlson, Elizabeth W, Cai, Tianxi

“…Typically, algorithms to classify phenotypes using electronic medical record (EMR) data were developed to perform well in a specific patient population. There…”
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Recent progress in rheumatoid arthritis genetics: one step towards improved patient care by Plenge, Robert M

“…PURPOSE OF REVIEWRecent human genetic discoveries have increased our understanding of rheumatoid arthritis (RA) susceptibility. These discoveries are reviewed…”
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The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1 by Li, Gang, Cunin, Pierre, Wu, Di, Diogo, Dorothée, Yang, Yu, Okada, Yukinori, Plenge, Robert M, Nigrovic, Peter A

“…Understanding the implications of genome-wide association studies (GWAS) for disease biology requires both identification of causal variants and definition of…”
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Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity by Han, Buhm, Diogo, Dorothée, Eyre, Steve, Kallberg, Henrik, Zhernakova, Alexandra, Bowes, John, Padyukov, Leonid, Okada, Yukinori, González-Gay, Miguel A., Rantapää-Dahlqvist, Solbritt, Martin, Javier, Huizinga, Tom W.J., Plenge, Robert M., Worthington, Jane, Gregersen, Peter K., Klareskog, Lars, de Bakker, Paul I.W., Raychaudhuri, Soumya

“…Despite progress in defining human leukocyte antigen (HLA) alleles for anti-citrullinated-protein-autoantibody-positive (ACPA+) rheumatoid arthritis (RA),…”
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X Chromosome–Inactivation Patterns of 1,005 Phenotypically Unaffected Females by Amos-Landgraf, James M., Cottle, Amy, Plenge, Robert M., Friez, Mike, Schwartz, Charles E., Longshore, John, Willard, Huntington F.

“…X-chromosome inactivation is widely believed to be random in early female development and to result in a mosaic distribution of cells, approximately half with…”
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Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients by Dargham, Soha R, Zahirovic, Sumeja, Hammoudeh, Mohammed, Al Emadi, Samar, Masri, Basel K, Halabi, Hussein, Badsha, Humeira, Uthman, Imad, Mahfoud, Ziyad R, Ashour, Hadil, Gad El Haq, Wissam, Bayoumy, Karim, Kapiri, Marianthi, Saxena, Richa, Plenge, Robert M, Kazkaz, Layla, Arayssi, Thurayya

“…There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe…”
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Automatic prediction of rheumatoid arthritis disease activity from the electronic medical records by Lin, Chen, Karlson, Elizabeth W, Canhao, Helena, Miller, Timothy A, Dligach, Dmitriy, Chen, Pei Jun, Perez, Raul Natanael Guzman, Shen, Yuanyan, Weinblatt, Michael E, Shadick, Nancy A, Plenge, Robert M, Savova, Guergana K

“…We aimed to mine the data in the Electronic Medical Record to automatically discover patients' Rheumatoid Arthritis disease activity at discrete rheumatology…”
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Quantifying missing heritability at known GWAS loci by Gusev, Alexander, Bhatia, Gaurav, Zaitlen, Noah, Vilhjalmsson, Bjarni J, Diogo, Dorothée, Stahl, Eli A, Gregersen, Peter K, Worthington, Jane, Klareskog, Lars, Raychaudhuri, Soumya, Plenge, Robert M, Pasaniuc, Bogdan, Price, Alkes L

“…Recent work has shown that much of the missing heritability of complex traits can be resolved by estimates of heritability explained by all genotyped SNPs…”
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Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus by Taylor, Kimberly E, Remmers, Elaine F, Lee, Annette T, Ortmann, Ward A, Plenge, Robert M, Tian, Chao, Chung, Sharon A, Nititham, Joanne, Hom, Geoffrey, Kao, Amy H, Demirci, F Yesim, Kamboh, M Ilyas, Petri, Michelle, Manzi, Susan, Kastner, Daniel L, Seldin, Michael F, Gregersen, Peter K, Behrens, Timothy W, Criswell, Lindsey A

“…Systemic lupus erythematosus (SLE) is a genetically complex disease with heterogeneous clinical manifestations. A polymorphism in the STAT4 gene has recently…”
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Genetic Basis of Autoantibody Positive and Negative Rheumatoid Arthritis Risk in a Multi-ethnic Cohort Derived from Electronic Health Records by Kurreeman, Fina, Liao, Katherine, Chibnik, Lori, Hickey, Brendan, Stahl, Eli, Gainer, Vivian, Li, Gang, Bry, Lynn, Mahan, Scott, Ardlie, Kristin, Thomson, Brian, Szolovits, Peter, Churchill, Susanne, Murphy, Shawn N., Cai, Tianxi, Raychaudhuri, Soumya, Kohane, Isaac, Karlson, Elizabeth, Plenge, Robert M.

“…Discovering and following up on genetic associations with complex phenotypes require large patient cohorts. This is particularly true for patient cohorts of…”
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Analysis and application of European genetic substructure using 300 K SNP information by Tian, Chao, Plenge, Robert M, Ransom, Michael, Lee, Annette, Villoslada, Pablo, Selmi, Carlo, Klareskog, Lars, Pulver, Ann E, Qi, Lihong, Gregersen, Peter K, Seldin, Michael F

“…European population genetic substructure was examined in a diverse set of >1,000 individuals of European descent, each genotyped with >300 K SNPs. Both…”
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Genetic analysis of human traits in vitro: drug response and gene expression in lymphoblastoid cell lines by Choy, Edwin, Yelensky, Roman, Bonakdar, Sasha, Plenge, Robert M, Saxena, Richa, De Jager, Philip L, Shaw, Stanley Y, Wolfish, Cara S, Slavik, Jacqueline M, Cotsapas, Chris, Rivas, Manuel, Dermitzakis, Emmanouil T, Cahir-McFarland, Ellen, Kieff, Elliott, Hafler, David, Daly, Mark J, Altshuler, David

“…Lymphoblastoid cell lines (LCLs), originally collected as renewable sources of DNA, are now being used as a model system to study genotype-phenotype…”
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A Multinational Arab Genome‐Wide Association Study Identifies New Genetic Associations for Rheumatoid Arthritis by Saxena, Richa, Plenge, Robert M., Bjonnes, Andrew C., Dashti, Hassan S., Okada, Yukinori, Gad El Haq, Wessam, Hammoudeh, Mohammed, Al Emadi, Samar, Masri, Basel K., Halabi, Hussein, Badsha, Humeira, Uthman, Imad W., Margolin, Lauren, Gupta, Namrata, Mahfoud, Ziyad R., Kapiri, Marianthi, Dargham, Soha R., Aranki, Grace, Kazkaz, Layla A., Arayssi, Thurayya

“…Objective Genetic factors underlying susceptibility to rheumatoid arthritis (RA) in Arab populations are largely unknown. This genome‐wide association study…”
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Priority index for human genetics and drug discovery by Plenge, Robert M.

“…Although human genetics can help identify new drug targets, the best way to prioritize genes as therapeutic targets is uncertain. A new study describes a…”
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Modeling disease severity in multiple sclerosis using electronic health records by Xia, Zongqi, Secor, Elizabeth, Chibnik, Lori B, Bove, Riley M, Cheng, Suchun, Chitnis, Tanuja, Cagan, Andrew, Gainer, Vivian S, Chen, Pei J, Liao, Katherine P, Shaw, Stanley Y, Ananthakrishnan, Ashwin N, Szolovits, Peter, Weiner, Howard L, Karlson, Elizabeth W, Murphy, Shawn N, Savova, Guergana K, Cai, Tianxi, Churchill, Susanne E, Plenge, Robert M, Kohane, Isaac S, De Jager, Philip L

“…To optimally leverage the scalability and unique features of the electronic health records (EHR) for research that would ultimately improve patient care, we…”
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