Search Results - "Plenge, Robert"

Disciplined approach to drug discovery and early development by Plenge, Robert M

“…Our modern health care system demands therapeutic interventions that improve the lives of patients. Unfortunately, decreased productivity in therapeutics…”
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Priority index for human genetics and drug discovery by Plenge, Robert M.

“…Although human genetics can help identify new drug targets, the best way to prioritize genes as therapeutic targets is uncertain. A new study describes a…”
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Validating therapeutic targets through human genetics by Plenge, Robert M., Scolnick, Edward M., Altshuler, David

“…Key Points Existing preclinical models have a limited ability to test 'therapeutic hypotheses'; that is, whether perturbing a target in a given manner would…”
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Molecular Underpinnings of Severe Coronavirus Disease 2019 by Plenge, Robert M

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JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease by O'Shea, John J., Plenge, Robert

“…The discovery of the Janus kinase (JAK)-signal transducer and activator of transcripton (STAT) signaling pathway, a landmark in cell biology, provided a simple…”
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Genomic atlas of the human plasma proteome by Sun, Benjamin B., Maranville, Joseph C., Peters, James E., Stacey, David, Staley, James R., Blackshaw, James, Burgess, Stephen, Jiang, Tao, Paige, Ellie, Surendran, Praveen, Oliver-Williams, Clare, Kamat, Mihir A., Prins, Bram P., Wilcox, Sheri K., Zimmerman, Erik S., Chi, An, Bansal, Narinder, Spain, Sarah L., Wood, Angela M., Morrell, Nicholas W., Bradley, John R., Janjic, Nebojsa, Roberts, David J., Ouwehand, Willem H., Todd, John A., Soranzo, Nicole, Suhre, Karsten, Paul, Dirk S., Fox, Caroline S., Plenge, Robert M., Danesh, John, Runz, Heiko, Butterworth, Adam S.

“…Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control…”
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Defining the role of the MHC in autoimmunity: a review and pooled analysis by Fernando, Michelle M A, Stevens, Christine R, Walsh, Emily C, De Jager, Philip L, Goyette, Philippe, Plenge, Robert M, Vyse, Timothy J, Rioux, John D

“…The major histocompatibility complex (MHC) is one of the most extensively studied regions in the human genome because of the association of variants at this…”
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Sequential immunotherapy: towards cures for autoimmunity by Ramírez-Valle, Francisco, Maranville, Joseph C., Roy, Sophie, Plenge, Robert M.

“…Despite major progress in the treatment of autoimmune diseases in the past two decades, most therapies do not cure disease and can be associated with increased…”
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Author Correction: Sequential immunotherapy: towards cures for autoimmunity by Ramírez-Valle, Francisco, Maranville, Joseph C., Roy, Sophie, Plenge, Robert M.

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Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts by Liao, Katherine P, Ananthakrishnan, Ashwin N, Kumar, Vishesh, Xia, Zongqi, Cagan, Andrew, Gainer, Vivian S, Goryachev, Sergey, Chen, Pei, Savova, Guergana K, Agniel, Denis, Churchill, Susanne, Lee, Jaeyoung, Murphy, Shawn N, Plenge, Robert M, Szolovits, Peter, Kohane, Isaac, Shaw, Stanley Y, Karlson, Elizabeth W, Cai, Tianxi

“…Typically, algorithms to classify phenotypes using electronic medical record (EMR) data were developed to perform well in a specific patient population. There…”
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Human genes lost and their functions found by Plenge, Robert M.

“…Individuals who lack a functional copy of a gene — gene knockouts — can reveal the gene's role. Most knockout research has used model organisms, but now a…”
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Biomedicine: Human genes lost and their functions found by Plenge, Robert M

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Principal components analysis corrects for stratification in genome-wide association studies by Price, Alkes L, Patterson, Nick J, Plenge, Robert M, Weinblatt, Michael E, Shadick, Nancy A, Reich, David

“…Population stratification--allele frequency differences between cases and controls due to systematic ancestry differences-can cause spurious associations in…”
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Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis by Raychaudhuri, Soumya, Sandor, Cynthia, Stahl, Eli A, Freudenberg, Jan, Lee, Hye-Soon, Jia, Xiaoming, Alfredsson, Lars, Padyukov, Leonid, Klareskog, Lars, Worthington, Jane, Siminovitch, Katherine A, Bae, Sang-Cheol, Plenge, Robert M, Gregersen, Peter K, de Bakker, Paul I W

“…Soumya Raychaudhuri, Paul de Bakker and colleagues report fine mapping of the rheumatoid arthritis associations within the MHC by combining genome-wide SNP…”
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The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1 by Li, Gang, Cunin, Pierre, Wu, Di, Diogo, Dorothée, Yang, Yu, Okada, Yukinori, Plenge, Robert M, Nigrovic, Peter A

“…Understanding the implications of genome-wide association studies (GWAS) for disease biology requires both identification of causal variants and definition of…”
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High-throughput phenotyping with electronic medical record data using a common semi-supervised approach (PheCAP) by Zhang, Yichi, Cai, Tianrun, Yu, Sheng, Cho, Kelly, Hong, Chuan, Sun, Jiehuan, Huang, Jie, Ho, Yuk-Lam, Ananthakrishnan, Ashwin N., Xia, Zongqi, Shaw, Stanley Y., Gainer, Vivian, Castro, Victor, Link, Nicholas, Honerlaw, Jacqueline, Huang, Sicong, Gagnon, David, Karlson, Elizabeth W., Plenge, Robert M., Szolovits, Peter, Savova, Guergana, Churchill, Susanne, O’Donnell, Christopher, Murphy, Shawn N., Gaziano, J. Michael, Kohane, Isaac, Cai, Tianxi, Liao, Katherine P.

“…Phenotypes are the foundation for clinical and genetic studies of disease risk and outcomes. The growth of biobanks linked to electronic medical record (EMR)…”
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Epidemiology and treatment patterns of rheumatoid arthritis in a large cohort of Arab patients by Dargham, Soha R, Zahirovic, Sumeja, Hammoudeh, Mohammed, Al Emadi, Samar, Masri, Basel K, Halabi, Hussein, Badsha, Humeira, Uthman, Imad, Mahfoud, Ziyad R, Ashour, Hadil, Gad El Haq, Wissam, Bayoumy, Karim, Kapiri, Marianthi, Saxena, Richa, Plenge, Robert M, Kazkaz, Layla, Arayssi, Thurayya

“…There is limited information on the epidemiology and treatment patterns of rheumatoid arthritis (RA) across the Arab region. We aim in this study to describe…”
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Automatic prediction of rheumatoid arthritis disease activity from the electronic medical records by Lin, Chen, Karlson, Elizabeth W, Canhao, Helena, Miller, Timothy A, Dligach, Dmitriy, Chen, Pei Jun, Perez, Raul Natanael Guzman, Shen, Yuanyan, Weinblatt, Michael E, Shadick, Nancy A, Plenge, Robert M, Savova, Guergana K

“…We aimed to mine the data in the Electronic Medical Record to automatically discover patients' Rheumatoid Arthritis disease activity at discrete rheumatology…”
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Quantifying missing heritability at known GWAS loci by Gusev, Alexander, Bhatia, Gaurav, Zaitlen, Noah, Vilhjalmsson, Bjarni J, Diogo, Dorothée, Stahl, Eli A, Gregersen, Peter K, Worthington, Jane, Klareskog, Lars, Raychaudhuri, Soumya, Plenge, Robert M, Pasaniuc, Bogdan, Price, Alkes L

“…Recent work has shown that much of the missing heritability of complex traits can be resolved by estimates of heritability explained by all genotyped SNPs…”
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Fine Mapping Seronegative and Seropositive Rheumatoid Arthritis to Shared and Distinct HLA Alleles by Adjusting for the Effects of Heterogeneity by Han, Buhm, Diogo, Dorothée, Eyre, Steve, Kallberg, Henrik, Zhernakova, Alexandra, Bowes, John, Padyukov, Leonid, Okada, Yukinori, González-Gay, Miguel A., Rantapää-Dahlqvist, Solbritt, Martin, Javier, Huizinga, Tom W.J., Plenge, Robert M., Worthington, Jane, Gregersen, Peter K., Klareskog, Lars, de Bakker, Paul I.W., Raychaudhuri, Soumya

“…Despite progress in defining human leukocyte antigen (HLA) alleles for anti-citrullinated-protein-autoantibody-positive (ACPA+) rheumatoid arthritis (RA),…”
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