Search Results - "Plenge, R. M."

Predictors of severe outcomes associated with Clostridium difficile infection in patients with inflammatory bowel disease by Ananthakrishnan, A. N., Guzman-Perez, R., Gainer, V., Cai, T., Churchill, S., Kohane, I., Plenge, R. M., Murphy, S.

“…Summary Background The increasing incidence of Clostridium difficile (C. difficile) infection (CDI) among patients with inflammatory bowel disease is well…”
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Psychiatric co‐morbidity is associated with increased risk of surgery in Crohn's disease by Ananthakrishnan, A. N., Gainer, V. S., Perez, R. G., Cai, T., Cheng, S.‐C., Savova, G., Chen, P., Szolovits, P., Xia, Z., Jager, P. L., Shaw, S. Y., Churchill, S., Karlson, E. W., Kohane, I., Perlis, R. H., Plenge, R. M., Murphy, S. N., Liao, K. P.

“…Summary Background Psychiatric co‐morbidity, in particular major depression and anxiety, is common in patients with Crohn's disease (CD) and ulcerative colitis…”
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Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance) by Chhibber, A, Mefford, J, Stahl, E A, Pendergrass, S A, Baldwin, R M, Owzar, K, Li, M, Winer, E P, Hudis, C A, Zembutsu, H, Kubo, M, Nakamura, Y, McLeod, H L, Ratain, M J, Shulman, L N, Ritchie, M D, Plenge, R M, Witte, J S, Kroetz, D L

“…Peripheral neuropathy is a common dose-limiting toxicity for patients treated with paclitaxel. For most individuals, there are no known risk factors that…”
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Fine mapping the TAGAP risk locus in rheumatoid arthritis by Chen, R, Stahl, E A, Kurreeman, F A S, Gregersen, P K, Siminovitch, K A, Worthington, J, Padyukov, L, Raychaudhuri, S, Plenge, R M

“…A common allele at the TAGAP gene locus demonstrates a suggestive, but not conclusive association with risk of rheumatoid arthritis (RA). To fine map the…”
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The influence of polygenic risk scores on heritability of anti-CCP level in RA by Cui, J, Taylor, K E, Lee, Y C, Källberg, H, Weinblatt, M E, Coblyn, J S, Klareskog, L, Criswell, L A, Gregersen, P K, Shadick, N A, Plenge, R M, Karlson, E W

“…The objective of this study was to study genetic factors that influence quantitative anticyclic citrullinated peptide (anti-CCP) antibody levels in RA…”
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Associations between human leukocyte antigen, PTPN22, CTLA4 genotypes and rheumatoid arthritis phenotypes of autoantibody status, age at diagnosis and erosions in a large cohort study by Karlson, E W, Chibnik, L B, Cui, J, Plenge, R M, Glass, R J, Maher, N E, Parker, A, Roubenoff, R, Izmailova, E, Coblyn, J S, Weinblatt, M E, Shadick, N A

“…HLA-DRB1 shared epitope (HLA-SE), PTPN22 and CTLA4 alleles are associated with cyclic citrullinated peptide (CCP) and rheumatoid arthritis (RA). We examined…”
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Heritability of X chromosome-inactivation phenotype in a large family by NAUMOVA, A. K, PLENGE, R. M, BIRD, L. M, LEPPERT, M, MORGAN, K, WILLARD, H. F, SAPIENZA, C

“…One of the two X chromosomes in each somatic cell of normal human females becomes inactivated very early in embryonic development. Although the inactivation of…”
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A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation by Plenge, Robert M, Hendrich, Brian D, Schwartz, Charles, Arena, J. Fernando, Naumova, Anna, Sapienza, Carmen, Winter, Robin M, Willard, Huntington F

“…X-chromosome inactivation is the process by which a cell recognizes the presence of two copies of an X chromosome early in the development of XX embryos and…”
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Gene-Gene and Gene-Environment Interactions Involving HLA-DRB1, PTPN22, and Smoking in Two Subsets of Rheumatoid Arthritis by Källberg, Henrik, Padyukov, Leonid, Plenge, Robert M., Rönnelid, Johan, Gregersen, Peter K., van der Helm-van Mil, Annette H.M., Toes, Rene E.M., Huizinga, Tom W., Klareskog, Lars, Alfredsson, Lars

“…Gene-gene and gene-environment interactions are key features in the development of rheumatoid arthritis (RA) and other complex diseases. The aim of this study…”
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GWAS in IMIDs by Plenge, R M

“…Human genetics offers one approach to understand dysregulation of the immune system in human diseases. [...] recently, a major bottleneck has been the…”
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Evidence That Mutations in the X-linked DDP Gene Cause Incompletely Penetrant and Variable Skewed X Inactivation by Plenge, Robert M., Tranebjaerg, Lisbeth, Jensen, Peter K.A., Schwartz, Charles, Willard, Huntington F.

“…X chromosome inactivation results in the random transcriptional silencing of one of the two X chromosomes early in female development. After random…”
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Skewed X-Chromosome Inactivation Is a Common Feature of X-Linked Mental Retardation Disorders by Plenge, Robert M., Stevenson, Roger A., Lubs, Herbert A., Schwartz, Charles E., Willard, Huntington F.

“…Some deleterious X-linked mutations may result in a growth disadvantage for those cells in which the mutation, when on the active X chromosome, affects cell…”
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Autosomal Dominant Mutations Affecting X Inactivation Choice in the Mouse by Percec, Ivona, Plenge, Robert M., Nadeau, Joseph H., Bartolomei, Marisa S., Willard, Huntington F.

“…X chromosome inactivation is the silencing mechanism eutherian mammals use to equalize the expression of X-linked genes between males and females early in…”
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Identification and characterization of the human XIST gene promoter: implications for models of X chromosome inactivation by Hendrich, Brian D., Plenge, Robert M., Willard, Huntington F.

“…The XIST gene in both humans and mice is expressed exclusively from the inactive X chromosome and is required for X chromosome inactivation to occur early in…”
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Predictors of severe outcomes associated with C lostridium difficile infection in patients with inflammatory bowel disease by Ananthakrishnan, A. N., Guzman‐Perez, R., Gainer, V., Cai, T., Churchill, S., Kohane, I., Plenge, R. M., Murphy, S.

“…Summary Background The increasing incidence of Clostridium difficile ( C. difficile ) infection ( CDI ) among patients with inflammatory bowel disease is well…”
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An N-Ethyl-N-Nitrosourea Mutagenesis Screen for Epigenetic Mutations in the Mouse by Percec, Ivona, Thorvaldsen, Joanne L, Plenge, Robert M, Krapp, Christopher J, Nadeau, Joseph H, Willard, Huntington F, Bartolomei, Marisa S

“…The mammalian epigenetic phenomena of X inactivation and genomic imprinting are incompletely understood. X inactivation equalizes X-linked expression between…”
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Using genetic and clinical data to understand response to disease-modifying anti-rheumatic drug therapy: data from the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study by Iannaccone, Christine K, Lee, Yvonne C, Cui, Jing, Frits, Michelle L, Glass, Roberta J, Plenge, Robert M, Solomon, Daniel H, Weinblatt, Michael E, Shadick, Nancy A

“…The objective of this review is to report on the progress of the Brigham and Women's Hospital Rheumatoid Arthritis Sequential Study (BRASS) Registry data…”
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Expression-based assay of an X-linked gene to examine effects of the X-controlling element (Xce) locus by Plenge, R M, Percec, I, Nadeau, J H, Willard, H F

“…Through an incompletely understood process, one of the two X chromosomes (Chrs) in mammalian XX female cells is inactivated, thereby achieving dosage…”
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Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis by Raychaudhuri, Soumya, Sandor, Cynthia, Stahl, Eli A, Freudenberg, Jan, Lee, Hye-Soon, Jia, Xiaoming, Alfredsson, Lars, Padyukov, Leonid, Klareskog, Lars, Worthington, Jane, Siminovitch, Katherine A, Bae, Sang-Cheol, Plenge, Robert M, Gregersen, Peter K, de Bakker, Paul I W

“…Soumya Raychaudhuri, Paul de Bakker and colleagues report fine mapping of the rheumatoid arthritis associations within the MHC by combining genome-wide SNP…”
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Genetic variants that predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis: current challenges and future directions by Plenge, Robert M, Criswell, Lindsey A

“…PURPOSE OF REVIEWTumor necrosis factor α (TNF) inhibitors are a mainstay of treatment in rheumatoid arthritis, yet there are no effective clinical or biomarker…”
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