Search Results - "Pledger, W. Jack"

Repurposing EGFR Inhibitor Utility in Colorectal Cancer in Mutant APC and TP53 Subpopulations by Yang, Mingli, Schell, Michael J, Loboda, Andrey, Nebozhyn, Michael, Li, Jiannong, Teer, Jamie K, Pledger, W Jack, Yeatman, Timothy J

“…EGFR is a major therapeutic target for colorectal cancer. Currently, extended testing identifies only nonresponders to EGFR inhibitors (EGFRi). We aimed to…”
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An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy by Yang, Mingli, Davis, Thomas B, Pflieger, Lance, Nebozhyn, Michael V, Loboda, Andrey, Wang, Heiman, Schell, Michael J, Thota, Ramya, Pledger, W Jack, Yeatman, Timothy J

“…Over half of colorectal cancers (CRCs) are hard-wired to RAS/RAF/MEK/ERK pathway oncogenic signaling. However, the promise of targeted therapeutic inhibitors,…”
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MDM2 Acts Downstream of p53 as an E3 Ligase to Promote FOXO Ubiquitination and Degradation by Fu, Wei, Ma, Qiuping, Chen, Lei, Li, Pengfei, Zhang, Mu, Ramamoorthy, Sivapriya, Nawaz, Zafar, Shimojima, Tsukasa, Wang, Hengbin, Yang, Yonghua, Shen, Zheng, Zhang, Yingtao, Zhang, Xiaohong, Nicosia, Santo V., Zhang, Yanping, Pledger, Jack W., Chen, Jiandong, Bai, Wenlong

“…Members of the FOXO (forkhead O) class of transcription factors are tumor suppressors that also control aging and organismal life span. Mammalian FOXO…”
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Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on src kinase for survival by SHOR, Audrey C, KESCHMAN, Elizabeth A, LEE, Francis Y, MURO-CACHO, Carlos, LETSON, G. Douglas, TRENT, Jonathan C, PLEDGER, W. Jack, JOVE, Richard

“…Sarcomas are rare malignant mesenchymal tumors for which there are limited treatment options. One potential molecular target for sarcoma treatment is the Src…”
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Proliferative status regulates HDAC11 mRNA abundance in nontransformed fibroblasts by Bagui, Tapan K, Sharma, Savitha S, Ma, Le, Pledger, W Jack

“…Histone deacetylases (HDACs) are important determinants of gene transcription and other biological processes. HDAC11 is one of the least characterized HDACs…”
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Identification of Aurora-A as a Direct Target of E2F3 during G2/M Cell Cycle Progression by He, Lili, Yang, Hua, Ma, Yihong, Pledger, W. Jack, Cress, W. Douglas, Cheng, Jin Q.

“…Aurora-A is a centrosome kinase and plays a pivotal role in G2/M cell cycle progression. Expression of Aurora-A is cell cycle-dependent. Levels of Aurora-A…”
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Roscovitine Inhibits Differentiation and Invasion in a Three-Dimensional Skin Reconstruction Model of Metastatic Melanoma by Mohapatra, Subhra, Coppola, Domenico, Riker, Adam I, Pledger, W Jack

“…The aim of this study was to investigate the therapeutic potential of a cyclin-dependent kinase inhibitor, roscovitine, in cultured melanoma cells and a…”
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The deubiquitylase USP7 is a novel cyclin F-interacting protein and regulates cyclin F protein stability by Sharma, Savitha S., Pledger, W. Jack, Kondaiah, Paturu

“…Cyclin F, unlike canonical and transcriptional cyclins, does not bind or activate any cyclin-dependent kinases. Instead, it harbors an F-box motif and…”
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Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis by Wang, Hong-Gang, Takahashi, Yoshinori, Coppola, Domenico, Matsushita, Norimasa, Cualing, Hernani D, Sun, Mei, Sato, Yuya, Liang, Chengyu, Jung, Jae U, Cheng, Jin Q, Mul, James J, Pledger, W. Jack

“…Autophagy is an evolutionarily conserved 'self-eating' process. Although the genes essential for autophagy (named Atg) have been identified in yeast, the…”
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PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation by Davis, Thomas B., Yang, Mingli, Schell, Michael J., Wang, Heiman, Ma, Le, Pledger, W. Jack, Yeatman, Timothy J.

“…Colorectal cancer (CRC) growth and progression is frequently driven by RAS pathway activation through upstream growth factor receptor activation or through…”
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PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC by Davis, Thomas B, Yang, Mingli, Wang, Heiman, Lee, Changgong, Yeatman, Timothy J, Pledger, W Jack

“…PTPRS is the most commonly mutated receptor tyrosine phosphatase in colorectal cancer (CRC). PTPRS has been shown to directly affect ERK and regulate its…”
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Identification of Aurora-A as a direct target of E2F3 during G2/M cell cycle progression by He, Lili, Yang, Hua, Ma, Yihong, Pledger, W. Jack, Cress, W. Douglas, Cheng, Jin Q.

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Assessing needs and assets for building a regional network infrastructure to reduce cancer related health disparities by Wells, Kristen J., Lima, Diana S., Meade, Cathy D., Muñoz-Antonia, Teresita, Scarinci, Isabel, McGuire, Allison, Gwede, Clement K., Pledger, W. Jack, Partridge, Edward, Lipscomb, Joseph, Matthews, Roland, Matta, Jaime, Flores, Idhaliz, Weiner, Roy, Turner, Timothy, Miele, Lucio, Wiese, Thomas E., Fouad, Mona, Moreno, Carlos S., Lacey, Michelle, Christie, Debra W., Price-Haywood, Eboni G., Quinn, Gwendolyn P., Coppola, Domenico, Sodeke, Stephen O., Green, B. Lee, Lichtveld, Maureen Y.

“…•We detail the efforts behind the development of the Region 3 GMaP/BMaP network.•The network is comprised of over 100 investigators from nine institutions.•We…”
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Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model by ADNANE, Jalila, JACKSON, Rosalind J, NICOSIA, Santo V, CANTOR, Alan B, PLEDGER, W. Jack, SEBTI, Saïd M

“…Upregulation of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 and subsequent cell growth arrest or senescence is one mechanism by which normal cells are…”
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Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice by Engelman, Robert W, Jackson, Rosalind J, Coppola, Domenico, Wharton, Walker, Cantor, Alan B, Pledger, W Jack

“…p21(Cip1/WAF1) localizes to the nucleus in response to gamma-irradiation induced DNA damage and mediates a G(1) checkpoint arrest. Although gamma-irradiated…”
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Loss of nuclear p21Cip1/WAF1 during neoplastic progression to metastasis in γ-irradiated p21 hemizygous mice by Engelman, Robert W., Jackson, Rosalind J., Coppola, Domenico, Wharton, Walker, Cantor, Alan B., Pledger, W. Jack

“…p21 Cip1 / WAF1 localizes to the nucleus in response to γ-irradiation induced DNA damage and mediates a G 1 checkpoint arrest. Although γ-irradiated p21 +/-…”
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p21Cip1 nullizygosity increases tumor metastasis in irradiated mice by JACKSON, Rosalind J, ENGELMAN, Robert W, COPPOLA, Domenico, CANTOR, Alan B, WHARTON, Walker, PLEDGER, W. Jack

“…p21(Cip1) is a cyclin-dependent kinase inhibitor whose abundance increases in cells exposed to radiation or other DNA-damaging agents. Such increases activate…”
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Activation of p27Kip1 Expression by E2F1 by Wang, Chuangui, Hou, Xinghua, Mohapatra, Subhra, Ma, Yihong, Cress, W. Douglas, Pledger, W. Jack, Chen, Jiandong

“…The E2F1 transcription factor is a critical regulator of cell cycle due to its ability to promote S phase entry. However, E2F1 overexpression also sensitizes…”
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Abstract 5789: A novel role of APC-partnering mutations in the sidedness of colorectal cancer survival by Yang, Mingli, Schell, Michael, Loboda, Andrey, Nebozhyn, Michael, Pledger, W. Jack, Yeatman, Timothy

“…Abstract Left-sided colorectal cancer (CRC) tumors have been reported to be more favorably associated with better survival than right-sided tumors. A molecular…”
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Abstract 1083: A novel role of SRC in mediating bypass resistance to MEK inhibition in colorectal cancer stem cells by Yang, Mingli, Davis, Thomas B. Davis B., Nebozhyn, Michael V., Loboda, Andrey, Wang, Heiman, Schell, Michael J., Pflieger, Lance, Thota, Ramya, Pledger, W. Jack, Yeatman, Timothy J.

“…Abstract Colorectal cancers (CRCs) are hard-wired to RAS/RAF/MEK/ERK pathway oncogenic signaling. However, the promise of targeted therapeutic inhibitors…”
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