Search Results - "Plebani, Roberto"

Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip by Bai, Haiqing, Si, Longlong, Jiang, Amanda, Belgur, Chaitra, Zhai, Yunhao, Plebani, Roberto, Oh, Crystal Yuri, Rodas, Melissa, Patil, Aditya, Nurani, Atiq, Gilpin, Sarah E., Powers, Rani K., Goyal, Girija, Prantil-Baun, Rachelle, Ingber, Donald E.

“…Mechanical breathing motions have a fundamental function in lung development and disease, but little is known about how they contribute to host innate…”
Get full text

3D Lung Tissue Models for Studies on SARS-CoV-2 Pathophysiology and Therapeutics by Plebani, Roberto, Bai, Haiqing, Si, Longlong, Li, Jing, Zhang, Chunhe, Romano, Mario

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), causing the coronavirus disease 2019 (COVID-19), has provoked more than six million deaths…”
Get full text

State of the Art in 3D Culture Models Applied to Thyroid Cancer by Prete, Alessandro, Matrone, Antonio, Plebani, Roberto

“…Thyroid cancer (TC) is the prevalent endocrine tumor with a rising incidence, particularly in higher-income countries, leading to an increased interest in its…”
Get full text

Loss of CFTR Reverses Senescence Hallmarks in SARS-CoV-2 Infected Bronchial Epithelial Cells by Merigo, Flavia, Lagni, Anna, Boschi, Federico, Bernardi, Paolo, Conti, Anita, Plebani, Roberto, Romano, Mario, Sorio, Claudio, Lotti, Virginia, Sbarbati, Andrea

“…SARS-CoV-2 infection has been recently shown to induce cellular senescence in vivo. A senescence-like phenotype has been reported in cystic fibrosis (CF)…”
Get full text

The Resolution Approach to Cystic Fibrosis Inflammation by Recchiuti, Antonio, Patruno, Sara, Plebani, Roberto, Romano, Mario

“…Despite the high expectations associated with the recent introduction of CFTR modulators, airway inflammation still remains a relevant clinical issue in cystic…”
Get full text

Vaginal microbiome-host interactions modeled in a human vagina-on-a-chip by Mahajan, Gautam, Doherty, Erin, To, Tania, Sutherland, Arlene, Grant, Jennifer, Junaid, Abidemi, Gulati, Aakanksha, LoGrande, Nina, Izadifar, Zohreh, Timilsina, Sanjay Sharma, Horváth, Viktor, Plebani, Roberto, France, Michael, Hood-Pishchany, Indriati, Rakoff-Nahoum, Seth, Kwon, Douglas S, Goyal, Girija, Prantil-Baun, Rachelle, Ravel, Jacques, Ingber, Donald E

“…A dominance of non-iners Lactobacillus species in the vaginal microbiome is optimal and strongly associated with gynecological and obstetric health, while the…”
Get full text

Skeletal muscle mitochondrial dysfunction mediated by Pseudomonas aeruginosa quorum-sensing transcription factor MvfR: reversing effects with anti-MvfR and mitochondrial-targeted compounds by Aggarwal, Shifu, Singh, Vijay, Chakraborty, Arijit, Cha, Sujin, Dimitriou, Alexandra, de Crescenzo, Claire, Izikson, Olivia, Yu, Lucy, Plebani, Roberto, Tzika, A Aria, Rahme, Laurence G

“…Sepsis and chronic infections with , a leading "ESKAPE" bacterial pathogen, are associated with increased morbidity and mortality and skeletal muscle atrophy…”
Get full text

Type-4 Phosphodiesterase (PDE4) Blockade Reduces NETosis in Cystic Fibrosis by Totani, Licia, Amore, Concetta, Piccoli, Antonio, Dell’Elba, Giuseppe, Di Santo, Angelo, Plebani, Roberto, Pecce, Romina, Martelli, Nicola, Rossi, Alice, Ranucci, Serena, De Fino, Ida, Moretti, Paolo, Bragonzi, Alessandra, Romano, Mario, Evangelista, Virgilio

“…Neutrophilic inflammation is a key determinant of cystic fibrosis (CF) lung disease. Neutrophil-derived free DNA, released in the form of extracellular traps…”
Get full text

CFTR Modulation Reduces SARS-CoV-2 Infection in Human Bronchial Epithelial Cells by Lotti, Virginia, Merigo, Flavia, Lagni, Anna, Di Clemente, Andrea, Ligozzi, Marco, Bernardi, Paolo, Rossini, Giada, Concia, Ercole, Plebani, Roberto, Romano, Mario, Sbarbati, Andrea, Sorio, Claudio, Gibellini, Davide

“…People with cystic fibrosis should be considered at increased risk of developing severe symptoms of COVID-19. Strikingly, a broad array of evidence shows…”
Get full text

A Systematic Review on Organ-on-a-Chip in PDMS or Hydrogel in Dentistry: An Update of the Literature by Pierfelice, Tania Vanessa, D'Amico, Emira, Petrini, Morena, Romano, Mario, D'Arcangelo, Camillo, Sbordone, Ludovico, Barone, Antonio, Plebani, Roberto, Iezzi, Giovanna

“…Organs-on-a-chip (OoCs) are microfluidic devices constituted by PDMS or hydrogel in which different layers of cells are separated by a semipermeable membrane…”
Get full text

Long-range Transcriptome Sequencing Reveals Cancer Cell Growth Regulatory Chimeric mRNA by Plebani, Roberto, Oliver, Gavin R, Trerotola, Marco, Guerra, Emanuela, Cantanelli, Pamela, Apicella, Luana, Emerson, Andrew, Albiero, Alessandro, Harkin, Paul D, Kennedy, Richard D, Alberti, Saverio

“…Abstract mRNA chimeras from chromosomal translocations often play a role as transforming oncogenes. However, cancer transcriptomes also contain mRNA chimeras…”
Get full text

Modeling pulmonary cystic fibrosis in a human lung airway-on-a-chip by Plebani, Roberto, Potla, Ratnakar, Soong, Mercy, Bai, Haiqing, Izadifar, Zohreh, Jiang, Amanda, Travis, Renee N., Belgur, Chaitra, Dinis, Alexandre, Cartwright, Mark J., Prantil-Baun, Rachelle, Jolly, Pawan, Gilpin, Sarah E., Romano, Mario, Ingber, Donald E.

“…•Human lung airway chip was created lined with cystic fibrosis patient cells.•Organ chip model recapitulates many features of cystic fibrosis lung in…”
Get full text

Generation of a live attenuated influenza A vaccine by proteolysis targeting by Si, Longlong, Shen, Quan, Li, Jing, Chen, Li, Shen, Jinying, Xiao, Xue, Bai, Haiqing, Feng, Tang, Ye, Adam Yongxin, Li, Le, Zhang, Chunhe, Li, Zhen, Wang, Ping, Oh, Crystal Yuri, Nurani, Atiq, Niu, Siwen, Zhang, Chengxin, Wei, Xiaoqiong, Yuan, Wanqiong, Liao, Hao, Huang, Xiaojie, Wang, Ning, Tian, Wen-xia, Tian, Hongwei, Li, Li, Liu, Xiaoheng, Plebani, Roberto

“…The usefulness of live attenuated virus vaccines has been limited by suboptimal immunogenicity, safety concerns or cumbersome manufacturing processes and…”
Get full text

microRNA-181b is increased in cystic fibrosis cells and impairs lipoxin A4 receptor-dependent mechanisms of inflammation resolution and antimicrobial defense by Pierdomenico, Anna Maria, Patruno, Sara, Codagnone, Marilina, Simiele, Felice, Mari, Veronica Cecilia, Plebani, Roberto, Recchiuti, Antonio, Romano, Mario

“…The involvement of microRNA (miR) in cystic fibrosis (CF) pathobiology is rapidly emerging. We previously documented that miR-181b controls the expression of…”
Get full text

Epigenetic regulation of the formyl peptide receptor 2 gene by Simiele, Felice, Recchiuti, Antonio, Patruno, Sara, Plebani, Roberto, Pierdomenico, Anna Maria, Codagnone, Marilina, Romano, Mario

“…Lipoxin (LX) A4, a main stop signal of inflammation, exerts potent bioactions by activating a specific G protein-coupled receptor, termed formyl peptide…”
Get full text

Mechanisms of endothelial cell dysfunction in cystic fibrosis by Totani, Licia, Plebani, Roberto, Piccoli, Antonio, Di Silvestre, Sara, Lanuti, Paola, Recchiuti, Antonio, Cianci, Eleonora, Dell'Elba, Giuseppe, Sacchetti, Silvio, Patruno, Sara, Guarnieri, Simone, Mariggiò, Maria A., Mari, Veronica C., Anile, Marco, Venuta, Federico, Del Porto, Paola, Moretti, Paolo, Prioletta, Marco, Mucilli, Felice, Marchisio, Marco, Pandolfi, Assunta, Evangelista, Virgilio, Romano, Mario

“…Although cystic fibrosis (CF) patients exhibit signs of endothelial perturbation, the functions of the cystic fibrosis conductance regulator (CFTR) in vascular…”
Get full text

Microvascular and Macrovascular Endothelial Cell Isolation and Purification from Lung-Derived Samples by Plebani, Roberto, D'Alessandro, Alessandra, Lanuti, Paola, Simeone, Pasquale, Cinalli, Massimiliano, Righi, Ilaria, Palleschi, Alessandro, Mucci, Matteo, Marchisio, Marco, Cappabianca, Francesco, Camera, Marina, Mucilli, Felice, Romano, Mario

“…The availability of cells isolated from healthy and diseased tissues and organs represents a key element for personalized medicine approaches. Although…”
Get more information

Establishment and long-term culture of human cystic fibrosis endothelial cells by Plebani, Roberto, Tripaldi, Romina, Lanuti, Paola, Recchiuti, Antonio, Patruno, Sara, Di Silvestre, Sara, Simeone, Pasquale, Anile, Marco, Venuta, Federico, Prioletta, Marco, Mucilli, Felice, Del Porto, Paola, Marchisio, Marco, Pandolfi, Assunta, Romano, Mario

“…Endothelial cell (EC) dysfunction has been reported in cystic fibrosis (CF) patients. Thus, the availability of CF EC is paramount to uncover mechanisms of…”
Get full text

microRNA-181b is increased in cystic fibrosis cells and impairs lipoxin A 4 receptor-dependent mechanisms of inflammation resolution and antimicrobial defense by Pierdomenico, Anna Maria, Patruno, Sara, Codagnone, Marilina, Simiele, Felice, Mari, Veronica Cecilia, Plebani, Roberto, Recchiuti, Antonio, Romano, Mario

“…The involvement of microRNA (miR) in cystic fibrosis (CF) pathobiology is rapidly emerging. We previously documented that miR-181b controls the expression of…”
Get full text

Long-range Transcriptome Sequencing Reveals Cancer Cell Growth Regulatory Chimeric mRNA12 by Plebani, Roberto, Oliver, Gavin R, Trerotola, Marco, Guerra, Emanuela, Cantanelli, Pamela, Apicella, Luana, Emerson, Andrew, Albiero, Alessandro, Harkin, Paul D, Kennedy, Richard D, Alberti, Saverio

“…mRNA chimeras from chromosomal translocations often play a role as transforming oncogenes. However, cancer transcriptomes also contain mRNA chimeras that may…”
Get full text