Search Results - "Pleban, Karin"

P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach by Pleban, Karin, Kopp, Stephan, Csaszar, Edina, Peer, Michael, Hrebicek, Thomas, Rizzi, Andreas, Ecker, Gerhard F, Chiba, Peter

“…P-glycoprotein (P-gp) is an energy-dependent multidrug efflux pump conferring resistance to cancer chemotherapy. Characterization of the mechanism of drug…”
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Inhibitors of p-glycoprotein--lead identification and optimisation by Pleban, Karin, Ecker, Gerhard F

“…The membrane bound drug efflux pump P-glycoprotein (P-gp) transports a wide variety of functionally and structurally diverse cytotoxic drugs out of tumour…”
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A three-dimensional model for the substrate binding domain of the multidrug ATP binding cassette transporter LmrA by Ecker, Gerhard F, Pleban, Karin, Kopp, Stephan, Csaszar, Edina, Poelarends, Gerrit J, Putman, Monique, Kaiser, Dominik, Konings, Wil N, Chiba, Peter

“…Multidrug resistance presents a major obstacle to the treatment of infectious diseases and cancer. LmrA, a bacterial ATP-dependent multidrug transporter,…”
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Homology model of the multidrug transporter LmrA from Lactococcus lactis by Pleban, Karin, Macchiarulo, Antonio, Costantino, Gabriele, Pellicciari, Roberto, Chiba, Peter, Ecker, Gerhard F.

“…Starting from the dimeric crystal structure of Vibrio cholerae MsbA, two homology models of the ATP-dependent multidrug transporter LmrA were generated. LmrA…”
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Structure–Activity Relationships, Ligand Efficiency, and Lipophilic Efficiency Profiles of Benzophenone-Type Inhibitors of the Multidrug Transporter P-Glycoprotein by Jabeen, Ishrat, Pleban, Karin, Rinner, Uwe, Chiba, Peter, Ecker, Gerhard F

“…The drug efflux pump P-glycoprotein (P-gp) has been shown to promote multidrug resistance (MDR) in tumors as well as to influence ADME properties of drug…”
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Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure–activity relationship by Murias, Marek, Handler, Norbert, Erker, Thomas, Pleban, Karin, Ecker, Gerhard, Saiko, Philipp, Szekeres, Thomas, Jäger, Walter

“…A series of hydroxylated and methoxylated trans-stilbenes were synthesized and evaluated for their ability to inhibit COX-1 and COX-2. Some of the hydroxylated…”
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Conjugation to 4-aminoquinoline improves the anti-trypanosomal activity of Deferiprone-type iron chelators by Gehrke, Sebastian S., Pinto, Erika G., Steverding, Dietmar, Pleban, Karin, Tempone, Andre G., Hider, Robert C., Wagner, Gerd K.

“…Iron is an essential growth component in all living organisms and plays a central role in numerous biochemical processes due to its redox potential and high…”
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Insights into Phenylalanine Derivatives Recognition of VLA-4 Integrin:  From a Pharmacophoric Study to 3D-QSAR and Molecular Docking Analyses by Macchiarulo, Antonio, Costantino, Gabriele, Meniconi, Mirco, Pleban, Karin, Ecker, Gerhard, Bellocchi, Daniele, Pellicciari, Roberto

“…The very late antigen-4 (VLA-4), also known as integrin α4β1, is expressed on monocytes, T- and B-lympohocytes, basophils, and eosinophils and is involved in…”
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Targeting drug-efflux pumps -- a pharmacoinformatic approach by Pleban, Karin, Kaiser, Dominik, Kopp, Stefan, Peer, Michael, Chiba, Peter, Ecker, Gerhard F

“…In line with our studies on propafenone-type inhibitors of P-glycoprotein (P-gp), we applied several methods to approach virtual screening tools for…”
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Intramolecular Distribution of Hydrophobicity Influences Pharmacological Activity of Propafenone-type MDR Modulators by Pleban, Karin, Hoffer, Claudia, Kopp, Stephan, Peer, Michael, Chiba, Peter, Ecker, Gerhard F.

“…Lipophilicity is one of the major determining physicochemical descriptors for P‐glycoprotein (P‐gp) inhibitory activity. Recently, Pajeva and Wiese showed that…”
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