Search Results - "Pleasance, E."

Whole genome and transcriptome analysis enhances precision cancer treatment options by Pleasance, E., Bohm, A., Williamson, L.M., Nelson, J.M.T., Shen, Y., Bonakdar, M., Titmuss, E., Csizmok, V., Wee, K., Hosseinzadeh, S., Grisdale, C.J., Reisle, C., Taylor, G.A., Lewis, E., Jones, M.R., Bleile, D., Sadeghi, S., Zhang, W., Davies, A., Pellegrini, B., Wong, T., Bowlby, R., Chan, S.K., Mungall, K.L., Chuah, E., Mungall, A.J., Moore, R.A., Zhao, Y., Deol, B., Fisic, A., Fok, A., Regier, D.A., Weymann, D., Schaeffer, D.F., Young, S., Yip, S., Schrader, K., Levasseur, N., Taylor, S.K., Feng, X., Tinker, A., Savage, K.J., Chia, S., Gelmon, K., Sun, S., Lim, H., Renouf, D.J., Jones, S.J.M., Marra, M.A., Laskin, J.

“…Recent advances are enabling delivery of precision genomic medicine to cancer clinics. While the majority of approaches profile panels of selected genes or…”
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Successful targeting of the NRG1 pathway indicates novel treatment strategy for metastatic cancer by Jones, M.R., Lim, H., Shen, Y., Pleasance, E., Ch'ng, C., Reisle, C., Leelakumari, S., Zhao, C., Yip, S., Ho, J., Zhong, E., Ng, T., Ionescu, D., Schaeffer, D.F., Mungall, A.J., Mungall, K.L., Zhao, Y., Moore, R.A., Ma, Y., Chia, S., Ho, C., Renouf, D.J., Gelmon, K., Jones, S.J.M., Marra, M.A., Laskin, J.

“…NRG1 fusion-positive lung cancers have emerged as potentially actionable events in lung cancer, but clinical support is currently limited and no evidence of…”
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ORegAnno: an open access database and curation system for literature-derived promoters, transcription factor binding sites and regulatory variation by Montgomery, S. B., Griffith, O. L., Sleumer, M. C., Bergman, C. M., Bilenky, M., Pleasance, E. D., Prychyna, Y., Zhang, X., Jones, S. J. M.

“…Motivation: Our understanding of gene regulation is currently limited by our ability to collectively synthesize and catalogue transcriptional regulatory…”
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Response to angiotensin blockade with irbesartan in a patient with metastatic colorectal cancer by Jones, M.R., Schrader, K.A., Shen, Y., Pleasance, E., Ch'ng, C., Dar, N., Yip, S., Renouf, D.J., Schein, J.E., Mungall, A.J., Zhao, Y., Moore, R., Ma, Y., Sheffield, B.S., Ng, T., Jones, S.J.M., Marra, M.A., Laskin, J., Lim, H.J.

“…A patient suffering from metastatic colorectal cancer, treatment-related toxicity and resistance to standard chemotherapy and radiation was assessed as part of…”
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FUS-NFATc2 sarcoma of bone, a novel molecular entity with aggressive behavior: Clinical and molecular pathology findings of two cases by Lacambra, M.D., Loong, H., To, K.F., Feng, X., Taylor, G., Pleasance, E., Laskin, J., Marra, M., Griffith, J., Yeung, H.Y.M., Wong, K.-C., Chow, C., Kumta, S., Ng, W.H.A., Tse, T., Tong, C., Ng, T.

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cisRED: a database system for genome-scale computational discovery of regulatory elements by Robertson, G., Bilenky, M., Lin, K., He, A., Yuen, W., Dagpinar, M., Varhol, R., Teague, K., Griffith, O. L., Zhang, X., Pan, Y., Hassel, M., Sleumer, M. C., Pan, W., Pleasance, E. D., Chuang, M., Hao, H., Li, Y. Y., Robertson, N., Fjell, C., Li, B., Montgomery, S. B., Astakhova, T., Zhou, J., Sander, J., Siddiqui, A. S., Jones, S. J. M.

“…We describe cisRED, a database for conserved regulatory elements that are identified and ranked by a genome-scale computational system (www.cisred.org). The…”
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232 Management of germline findings revealed throughout the course of tumor-normal whole genome sequencing in oncology by Lim, H, Schrader, K, Young, S, Fok, A, Pleasance, E, Jones, M, Shen, Y, Armstrong, L, Virani, A, Rassekh, S, Deyell, R, Yip, S, Roscoe, R, Karsan, A, Marra, M, Laskin, J

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231 Whole genome analysis in a population-based cancer system: Results from sequencing >100 metastatic cancer patients by Lim, H, Renouf, D, Sun, S, Ho, C, Gelmon, K, Chia, S, Pleasance, E, Jones, M, Shen, Y, Eirew, P, Rassekh, S, Deyell, R, Yip, S, Huntsman, D, Roscoe, R, Fok, A, Ma, Y, Jones, S

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Personalized oncogenomics in the management of gastrointestinal carcinomas-early experiences from a pilot study by Sheffield, B S, Tessier-Cloutier, B, Li-Chang, H, Shen, Y, Pleasance, E, Kasaian, K, Li, Y, Jones, S J M, Lim, H J, Renouf, D J, Huntsman, D G, Yip, S, Laskin, J, Marra, M, Schaeffer, D F

“…Gastrointestinal carcinomas are genomically complex cancers that are lethal in the metastatic setting. Whole-genome and transcriptome sequencing allow for the…”
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Serial analysis of gene expression in the southern cattle tick following acaricide treatment of larvae from organophosphate resistant and susceptible strains by Guerrero, F.D, Bendele, K.G, Chen, A.C, Li, A.Y, Miller, R.J, Pleasance, E, Varhol, R, Rousseau, M.-E, Nene, V.M

“…Organophosphate resistant and susceptible tick larvae from laboratory strains of the southern cattle tick, Rhipicephalus (Boophilus) microplus were exposed to…”
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1256PPredictive markers of checkpoint inhibitor activity in adult metastatic solid tumours by Pender, A, Titmuss, E, Pleasance, E, Fan, K, Pearson, H, Bonakdar, M, Taylor, G, Mungall, K, Moore, R, Lavoie, J-M, Yip, S, Lim, H, Renouf, D, Jones, S J, Marra, M A, Laskin, J J

“…Abstract Background Immune checkpoint inhibitors (CPI) have revolutionised the treatment of solid tumours with durable responses in cancers with previously…”
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Predictive markers of checkpoint inhibitor activity in adult metastatic solid tumours by Pender, A., Titmuss, E., Pleasance, E., Fan, K., Pearson, H., Bonakdar, M., Taylor, G., Mungall, K., Moore, R., Lavoie, J.-M., Yip, S., Lim, H., Renouf, D., Jones, S.J., Marra, M.A., Laskin, J.J.

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1256P - Predictive markers of checkpoint inhibitor activity in adult metastatic solid tumours by Pender, A., Titmuss, E., Pleasance, E., Fan, K., Pearson, H., Bonakdar, M., Taylor, G., Mungall, K., Moore, R., Lavoie, J.-M., Yip, S., Lim, H., Renouf, D., Jones, S.J., Marra, M.A., Laskin, J.J.

“…Immune checkpoint inhibitors (CPI) have revolutionised the treatment of solid tumours with durable responses in cancers with previously limited treatment…”
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410PFUS-NFATc2 sarcoma of bone, a novel molecular entity with aggressive behavior: Clinical and molecular pathology findings of two cases by Lacambra, M D, Loong, H, To, K F, Feng, X, Taylor, G, Pleasance, E, Laskin, J, Marra, M, Griffith, J, Yeung, H Y M, Wong, K-C, Chow, C, Kumta, S, Ng, W H A, Tse, T, Tong, C, Ng, T

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Practical Guidelines for Ethical and Policy Issues that Arise from the Clinical Application of Whole Genome Sequencing in Cancer Patients by Lim, H., Virani, A., Fok, A., Karsan, A., Renouf, D., Gelmon, K.A., Yip, S., Chia, S., Sun, S., Tinker, A., Lee, S.J., Rassekh, R., Deyell, R., Roscoe, R., Jones, S., Pleasance, E., Marra, M., Laskin, J.

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1615PPRACTICAL GUIDELINES FOR ETHICAL AND POLICY ISSUES THAT ARISE FROM THE CLINICAL APPLICATION OF WHOLE GENOME SEQUENCING IN CANCER PATIENTS by Lim, H., Virani, A., Fok, A., Karsan, A., Renouf, D., Gelmon, K.A., Yip, S., Chia, S., Sun, S., Tinker, A., Lee, S.J., Rassekh, R., Deyell, R., Roscoe, R., Jones, S., Pleasance, E., Marra, M., Laskin, J.

“…Abstract Aim: Our group utilizes whole genome sequencing (WGS) to identify candidate driver pathways to guide personalized treatment decisions in oncology…”
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A SAGE Approach to Discovery of Genes Involved in Autophagic Cell Death by Gorski, Sharon M., Chittaranjan, Suganthi, Pleasance, Erin D., Freeman, J.D., Anderson, Carrie L., Varhol, Richard J., Coughlin, Shaun M., Zuyderduyn, Scott D., Jones, Steven J.M., Marra, Marco A.

“…Programmed cell death (PCD), important in normal animal physiology and disease, can be divided into at least two morphological subtypes, including type I, or…”
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Assessment of SAGE in transcript identification by Pleasance, Erin D, Marra, Marco A, Jones, Steven J M

“…An essential step in Serial Analysis of Gene Expression (SAGE) is tag mapping, which refers to the unambiguous determination of the gene represented by a SAGE…”
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Assessment and integration of publicly available SAGE, cDNA microarray, and oligonucleotide microarray expression data for global coexpression analyses by Griffith, Obi L., Pleasance, Erin D., Fulton, Debra L., Oveisi, Mehrdad, Ester, Martin, Siddiqui, Asim S., Jones, Steven J.M.

“…Large amounts of gene expression data from several different technologies are becoming available to the scientific community. A common practice is to use these…”
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Intravenous anaesthesia, past and present by PLEASANCE, R E

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