Search Results - "Player, Darren J"

Mechanical loading stimulates hypertrophy in tissue‐engineered skeletal muscle: Molecular and phenotypic responses by Aguilar‐Agon, Kathryn W., Capel, Andrew J., Martin, Neil R.W., Player, Darren J., Lewis, Mark P.

“…Mechanical loading of skeletal muscle results in molecular and phenotypic adaptations typified by enhanced muscle size. Studies on humans are limited by the…”
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Neuromuscular Junction Formation in Tissue-Engineered Skeletal Muscle Augments Contractile Function and Improves Cytoskeletal Organization by Martin, Neil R W, Passey, Samantha L, Player, Darren J, Mudera, Vivek, Baar, Keith, Greensmith, Linda, Lewis, Mark P

“…Neuromuscular and neurodegenerative diseases are conditions that affect both motor neurons and the underlying skeletal muscle tissue. At present, the majority…”
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Mechanical loading of tissue engineered skeletal muscle prevents dexamethasone induced myotube atrophy by Aguilar-Agon, Kathryn W., Capel, Andrew J., Fleming, Jacob W., Player, Darren J., Martin, Neil R. W., Lewis, Mark P.

“…Skeletal muscle atrophy as a consequence of acute and chronic illness, immobilisation, muscular dystrophies and aging, leads to severe muscle weakness,…”
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Leucine elicits myotube hypertrophy and enhances maximal contractile force in tissue engineered skeletal muscle in vitro by Martin, Neil R.W., Turner, Mark C., Farrington, Robert, Player, Darren J., Lewis, Mark P.

“…The amino acid leucine is thought to be important for skeletal muscle growth by virtue of its ability to acutely activate mTORC1 and enhance muscle protein…”
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Factors affecting the structure and maturation of human tissue engineered skeletal muscle by Martin, Neil R.W, Passey, Samantha L, Player, Darren J, Khodabukus, Alastair, Ferguson, Richard A, Sharples, Adam P, Mudera, Vivek, Baar, Keith, Lewis, Mark P

“…Abstract Tissue engineered skeletal muscle has great utility in experimental studies of physiology, clinical testing and its potential for transplantation to…”
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Hypoxia Impairs Muscle Function and Reduces Myotube Size in Tissue Engineered Skeletal Muscle by Martin, Neil R.W., Aguilar‐Agon, Kathyrn, Robinson, George P., Player, Darren J., Turner, Mark C., Myers, Stephen D., Lewis, Mark P.

“…ABSTRACT Contemporary tissue engineered skeletal muscle models display a high degree of physiological accuracy compared with native tissue, and therefore may…”
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Creating Interactions between Tissue-Engineered Skeletal Muscle and the Peripheral Nervous System by Smith, Alec S T, Passey, Samantha L, Martin, Neil R W, Player, Darren J, Mudera, Vivek, Greensmith, Linda, Lewis, Mark P

“…Effective models of mammalian tissues must allow and encourage physiologically (mimetic) correct interactions between co-cultured cell types in order to…”
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Scalable 3D Printed Molds for Human Tissue Engineered Skeletal Muscle by Capel, Andrew J, Rimington, Rowan P, Fleming, Jacob W, Player, Darren J, Baker, Luke A, Turner, Mark C, Jones, Julia M, Martin, Neil R W, Ferguson, Richard A, Mudera, Vivek C, Lewis, Mark P

“…Tissue engineered skeletal muscle allows investigation of the cellular and molecular mechanisms that regulate skeletal muscle pathology. The fabricated model…”
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Neuregulin 1 Drives Morphological and Phenotypical Changes in C2C12 Myotubes: Towards De Novo Formation of Intrafusal Fibres In Vitro by Barrett, Philip, Quick, Tom J, Mudera, Vivek, Player, Darren J

“…Muscle spindles are sensory organs that detect and mediate both static and dynamic muscle stretch and monitor muscle position, through a specialised cell…”
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An Assessment of Myotube Morphology, Matrix Deformation, and Myogenic mRNA Expression in Custom-Built and Commercially Available Engineered Muscle Chamber Configurations by Jones, Julia M, Player, Darren J, Martin, Neil R W, Capel, Andrew J, Lewis, Mark P, Mudera, Vivek

“…There are several three-dimensional (3D) skeletal muscle (SkM) tissue engineered models reported in the literature. 3D SkM tissue engineering (TE) aims to…”
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Controlled Arrangement of Neuronal Cells on Surfaces Functionalized with Micropatterned Polymer Brushes by Pardo-Figuerez, Maria, Martin, Neil R. W, Player, Darren J, Roach, Paul, Christie, Steven D. R, Capel, Andrew J, Lewis, Mark P

“…Conventional in vitro cultures are useful to represent simplistic neuronal behavior; however, the lack of organization results in random neurite spreading. To…”
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Development of tissue‐engineered skeletal muscle manufacturing variables by Wragg, Nicholas M., Player, Darren J., Martin, Neil R. W., Liu, Yang, Lewis, Mark P.

“…Three‐dimensional tissue‐engineered structures enable more representative determination of novel drug or material effects on tissue than traditional monolayer…”
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The effect of chronic high insulin exposure upon metabolic and myogenic markers in C2C12 skeletal muscle cells and myotubes by Turner, Mark C., Player, Darren J., Martin, Neil R.W., Akam, Elizabeth C., Lewis, Mark P.

“…Skeletal muscle is an insulin sensitive tissue and accounts for approximately 80% of post‐prandial glucose disposal. This study describes the effects of…”
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The acute angiogenic signalling response to low-load resistance exercise with blood flow restriction by Ferguson, Richard A., Hunt, Julie E. A., Lewis, Mark P., Martin, Neil R. W., Player, Darren J., Stangier, Carolin, Taylor, Conor W., Turner, Mark C.

“…This study investigated protein kinase activation and gene expression of angiogenic factors in response to low-load resistance exercise with or without blood…”
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Characterising hyperinsulinemia-induced insulin resistance in human skeletal muscle cells by Turner, Mark C, Martin, Neil R W, Player, Darren J, Ferguson, Richard A, Wheeler, Patrick, Green, Charlotte J, Akam, Elizabeth C, Lewis, Mark P

“…Hyperinsulinaemia potentially contributes to insulin resistance in metabolic tissues, such as skeletal muscle. The purpose of these experiments was to…”
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Feasibility and Biocompatibility of 3D‐Printed Photopolymerized and Laser Sintered Polymers for Neuronal, Myogenic, and Hepatic Cell Types by Rimington, Rowan P., Capel, Andrew J., Player, Darren J., Bibb, Richard J., Christie, Steven D. R., Lewis, Mark P.

“…The integration of additive manufacturing (AM) technology within biological systems holds significant potential, specifically when refining the methods…”
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Functional regeneration of tissue engineered skeletal muscle in vitro is dependent on the inclusion of basement membrane proteins by Fleming, Jacob W., Capel, Andrew J., Rimington, Rowan P., Player, Darren J., Stolzing, Alexandra, Lewis, Mark P.

“…Skeletal muscle has a high regenerative capacity, injuries trigger a regenerative program which restores tissue function to a level indistinguishable to the…”
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Modelling in vivo skeletal muscle ageing in vitro using three‐dimensional bioengineered constructs by Sharples, Adam P., Player, Darren J., Martin, Neil R. W., Mudera, Vivek, Stewart, Claire E., Lewis, Mark P.

“…Summary Degeneration of skeletal muscle (SkM) with age (sarcopenia) is a major contributor to functional decline, morbidity and mortality. Methodological…”
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Effects of photobiomodulation therapy on regulation of myogenic regulatory factor mRNA expression in vivo: A systematic review by Shepherd, David W., Norris, Joseph M., Simpson, Benjamin S., Player, Darren J., Whitaker, Hayley C.

“…Non‐invasive promotion of myogenic regulatory factors (MRFs), through photobiomodulation therapy (PBMT), may be a viable method of facilitating skeletal muscle…”
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Generating intrafusal skeletal muscle fibres in vitro: Current state of the art and future challenges by Barrett, Philip, Quick, Tom J, Mudera, Vivek, Player, Darren J

“…Intrafusal fibres are a specialised cell population in skeletal muscle, found within the muscle spindle. These fibres have a mechano-sensory capacity, forming…”
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