Search Results - "Plavina, Tatiana"

Risk of Natalizumab-Associated Progressive Multifocal Leukoencephalopathy by Bloomgren, Gary, Richman, Sandra, Hotermans, Christophe, Subramanyam, Meena, Goelz, Susan, Natarajan, Amy, Lee, Sophia, Plavina, Tatiana, Scanlon, James V, Sandrock, Alfred, Bozic, Carmen

“…In patients treated with natalizumab, PML incidence was about 11 cases per 1000 patients with 25 to 48 months of treatment, prior immunosuppressant use, and…”
Get full text

N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection by Shan, Dandan, Johnson, Joseph M., Fernandes, Syrena C., Suib, Hannah, Hwang, Soyoon, Wuelfing, Danica, Mendes, Muriel, Holdridge, Marcella, Burke, Elaine M., Beauregard, Katie, Zhang, Ying, Cleary, Megan, Xu, Samantha, Yao, Xiao, Patel, Purvish P., Plavina, Tatiana, Wilson, David H., Chang, Lei, Kaiser, Kim M., Nattermann, Jacob, Schmidt, Susanne V., Latz, Eicke, Hrusovsky, Kevin, Mattoon, Dawn, Ball, Andrew J.

“…The COVID-19 pandemic continues to have an unprecedented impact on societies and economies worldwide. There remains an ongoing need for high-performance…”
Get full text

Anti-JC virus antibody levels in serum or plasma further define risk of natalizumab-associated progressive multifocal leukoencephalopathy by Plavina, Tatiana, Subramanyam, Meena, Bloomgren, Gary, Richman, Sandra, Pace, Amy, Lee, Sophia, Schlain, Brian, Campagnolo, Denise, Belachew, Shibeshih, Ticho, Barry

“…Objective The increased risk of progressive multifocal leukoencephalopathy (PML) with natalizumab treatment is associated with the presence of anti–JC virus…”
Get full text

Neurofilament light levels are associated with long-term outcomes in multiple sclerosis by Kuhle, Jens, Plavina, Tatiana, Barro, Christian, Disanto, Giulio, Sangurdekar, Dipen, Singh, Carol M, de Moor, Carl, Engle, Bob, Kieseier, Bernd C, Fisher, Elizabeth, Kappos, Ludwig, Rudick, Richard A, Goyal, Jaya

“…Background: Neurofilament light chain (NfL) is a promising marker of disease activity/treatment response in multiple sclerosis (MS), although its predictive…”
Get full text

Serum neurofilament light levels in natalizumab-treated patients with multiple sclerosis who switch to extended interval dosing from every-4-week dosing in real-world clinical practice by Foley, John, Xiong, Kuangnan, Hoyt, Tammy, Singh, Carol M, Riddle, Evan, de Moor, Carl, Plavina, Tatiana, Campbell, Nolan

“…Background: Serum levels of neurofilament light chain (sNfL) are a potentially useful biomarker for assessing the efficacy of multiple sclerosis (MS)…”
Get full text

A second-generation ELISA (STRATIFY JCV™ DxSelect™) for detection of JC virus antibodies in human serum and plasma to support progressive multifocal leukoencephalopathy risk stratification by Lee, Peter, Plavina, Tatiana, Castro, Albert, Berman, Melissa, Jaiswal, Dipeshkumar, Rivas, Suzanne, Schlain, Brian, Subramanyam, Meena

“…Abstract Background JC virus (JCV) infection is a prerequisite for development of progressive multifocal leukoencephalopathy (PML). The development and…”
Get full text

Anti-John Cunnigham virus antibody prevalence in multiple sclerosis patients: Baseline results of STRATIFY-1 by Bozic, Carmen, Richman, Sandra, Plavina, Tatiana, Natarajan, Amy, Scanlon, James V., Subramanyam, Meena, Sandrock, Alfred, Bloomgren, Gary

“…Objective: A study was undertaken to define the prevalence of anti‐JC virus (JCV) antibodies in multiple sclerosis (MS) patients and to evaluate the analytical…”
Get full text

Temporal profile of serum neurofilament light in multiple sclerosis: Implications for patient monitoring by Calabresi, Peter A, Arnold, Douglas L, Sangurdekar, Dipen, Singh, Carol M, Altincatal, Arman, de Moor, Carl, Engle, Bob, Goyal, Jaya, Deykin, Aaron, Szak, Suzanne, Kieseier, Bernd C, Rudick, Richard A, Plavina, Tatiana

“…Objective: To understand how longitudinal serum neurofilament light chain (sNfL) patterns can inform its use as a prognostic biomarker in multiple sclerosis…”
Get full text

Reversibility of the effects of natalizumab on peripheral immune cell dynamics in MS patients by Plavina, Tatiana, Muralidharan, Kumar Kandadi, Kuesters, Geoffrey, Mikol, Daniel, Evans, Karleyton, Subramanyam, Meena, Nestorov, Ivan, Chen, Yi, Dong, Qunming, Ho, Pei-Ran, Amarante, Diogo, Adams, Alison, De Sèze, Jerome, Fox, Robert, Gold, Ralf, Jeffery, Douglas, Kappos, Ludwig, Montalban, Xavier, Weinstock-Guttman, Bianca, Hartung, Hans-Peter, Cree, Bruce A.C

“…OBJECTIVE:To characterize the reversibility of natalizumab-mediated changes in pharmacokinetics/pharmacodynamics in patients with multiple sclerosis (MS)…”
Get full text

Stability and predictive value of anti-JCV antibody index in multiple sclerosis: A 6-year longitudinal study by Hegen, Harald, Auer, Michael, Bsteh, Gabriel, Di Pauli, Franziska, Plavina, Tatiana, Walde, Janette, Deisenhammer, Florian, Berger, Thomas

“…Risk of natalizumab-related progressive multifocal leukoencephalopathy is associated with the presence of anti-JC-virus (JCV) antibodies. To investigate the…”
Get full text

Development of a Highly Sensitive Neurofilament Light Chain Assay on an Automated Immunoassay Platform by Lee, Stephen, Plavina, Tatiana, Singh, Carol M., Xiong, Kuangnan, Qiu, Xiaolei, Rudick, Richard A., Calabresi, Peter A., Stevenson, Lauren, Graham, Danielle, Raitcheva, Denitza, Green, Christopher, Matias, Madeleine, Uzgiris, Arejas J.

“…Background Neurofilament light chain (NfL) is an axonal cytoskeletal protein that is released into the extracellular space following neuronal or axonal injury…”
Get full text

Lymphotoxin-LIGHT pathway regulates the interferon signature in rheumatoid arthritis by Bienkowska, Jadwiga, Allaire, Norm, Thai, Alice, Goyal, Jaya, Plavina, Tatiana, Nirula, Ajay, Weaver, Megan, Newman, Charlotte, Petri, Michelle, Beckman, Evan, Browning, Jeffrey L

“…A subset of patients with autoimmune diseases including rheumatoid arthritis (RA) and lupus appear to be exposed continually to interferon (IFN) as evidenced…”
Get full text

Combination of Abundant Protein Depletion and Multi-Lectin Affinity Chromatography (M-LAC) for Plasma Protein Biomarker Discovery by Plavina, Tatiana, Wakshull, Eric, Hancock, William S, Hincapie, Marina

“…We report on the development of a robust and relatively high-throughput method for in-depth proteomic analysis of human plasma suitable for biomarker…”
Get full text

Anti-JC virus antibody prevalence in a multinational multiple sclerosis cohort by Olsson, Tomas, Achiron, Anat, Alfredsson, Lars, Berger, Thomas, Brassat, David, Chan, Andrew, Comi, Giancarlo, Eraksoy, Mefkure, Hegen, Harald, Hillert, Jan, Jensen, Poul Erik Hyldgaard, Moiola, Lucia, Myhr, Kjell-Morten, Oturai, Annette, Schippling, Sven, Siva, Aksel, Sorensen, Per Soelberg, Trampe, Anne-Kathrin, Weber, Thomas, Potts, James, Plavina, Tatiana, Paes, Dominic, Subramanyam, Meena, Wiendl, Heinz, Dib, Hussein, Üren, Deniz, Hemmer, Bernhard, Buck, Dorothea

“…JC virus (JCV) is an opportunistic virus known to cause progressive multifocal leukoencephalopathy. Anti-JC virus (Anti-JCV) antibody prevalence in a large,…”
Get full text

Feasibility of the use of combinatorial chemokine arrays to study blood and CSF in multiple sclerosis by Edwards, Keith R, Goyal, Jaya, Plavina, Tatiana, Czerkowicz, Julie, Goelz, Susan, Ranger, Ann, Cadavid, Diego, Browning, Jeffrey L

“…Meningeal inflammation, including the presence of semi-organized tertiary lymphoid tissue, has been associated with cortical pathology at autopsy in secondary…”
Get full text

Measuring treatment response to advance precision medicine for multiple sclerosis by Calabresi, Peter A., Kappos, Ludwig, Giovannoni, Gavin, Plavina, Tatiana, Koulinska, Irene, Edwards, Michael R., Kieseier, Bernd, Moor, Carl, Sotirchos, Elias S., Fisher, Elizabeth, Rudick, Richard A., Sandrock, Alfred

“…Objective To assess the independent contributions of clinical measures (relapses, Expanded Disability Status Scale [EDSS] scores, and neuroperformance…”
Get full text

Dimethyl fumarate decreases neurofilament light chain in CSF and blood of treatment naïve relapsing MS patients by Sejbaek, Tobias, Nielsen, Helle Hvilsted, Penner, Natasha, Plavina, Tatiana, Mendoza, Jason P, Martin, Nellie Anne, Elkjaer, Maria Louise, Ravnborg, Mads Henrik, Illes, Zsolt

“…ObjectivesIn a prospective phase IV trial of the first-line oral treatment dimethyl fumarate (DMF), we examined dynamics of neurofilament light (NFL) chain in…”
Get full text

Serum neurofilament light as a biomarker in progressive multiple sclerosis by Kapoor, Raju, Smith, Kathryn E., Allegretta, Mark, Arnold, Douglas L., Carroll, William, Comabella, Manuel, Furlan, Roberto, Harp, Christopher, Kuhle, Jens, Leppert, David, Plavina, Tatiana, Sellebjerg, Finn, Sincock, Caroline, Teunissen, Charlotte E., Topalli, Ilir, von Raison, Florian, Walker, Elizabeth, Fox, Robert J.

“…There is an unmet need in multiple sclerosis (MS) therapy for treatments to stop progressive disability. The development of treatments may be accelerated if…”
Get full text

Baseline levels of neurofilament light chain in the cerebrospinal fluid correlate with clinical outcomes in patients with MPS II from a phase 2/3 clinical trial (NCT02055118) and extension study (NCT02412787) of intrathecal idursulfase by Argueta, Christian, Ahmed, Mariam, Brekk, Oeystein R., McDonnell, Scott, Pan, Luying, Plavina, Tatiana, Whiteman, David

Get full text

Blood neurofilament light levels segregate treatment effects in multiple sclerosis by Delcoigne, Bénédicte, Manouchehrinia, Ali, Barro, Christian, Benkert, Pascal, Michalak, Zuzanna, Kappos, Ludwig, Leppert, David, Tsai, Jon A., Plavina, Tatiana, Kieseier, Bernd C., Lycke, Jan, Alfredsson, Lars, Kockum, Ingrid, Kuhle, Jens, Olsson, Tomas, Piehl, Fredrik

“…OBJECTIVETo determine factors (including the role of specific disease modulatory treatments [DMTs]) associated with (1) baseline, (2) on-treatment, and (3)…”
Get full text