Search Results - "Platta, Harald W."

mTOR: A Cellular Regulator Interface in Health and Disease by Boutouja, Fahd, Stiehm, Christian M, Platta, Harald W

“…The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine kinase, which has a central function in integrating growth signals and…”
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Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1 by Platta, Harald W, Abrahamsen, Hilde, Thoresen, Sigrid B, Stenmark, Harald

“…Beclin 1, a subunit of the class III phosphatidylinositol 3-kinase complex, is a tumour suppressor with a central role in endocytic trafficking, cytokinesis…”
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Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression by Abrahamsen, Hilde, Stenmark, Harald, Platta, Harald W.

“…The class III phosphatidylinositol 3-kinase (PI3K-III) complex and its phosphorylated lipid product phosphatidylinositol 3-phosphate (PtdIns3P) control the…”
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Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades by Boutouja, Fahd, Brinkmeier, Rebecca, Mastalski, Thomas, El Magraoui, Fouzi, Platta, Harald W

“…Autophagy contributes to cellular homeostasis through the degradation of various intracellular targets such as proteins, organelles and microbes. This relates…”
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The Peroxisomal PTS1-Import Defect of PEX1 - Deficient Cells Is Independent of Pexophagy in Saccharomyces cerevisiae by Mastalski, Thomas, Brinkmeier, Rebecca, Platta, Harald W

“…The important physiologic role of peroxisomes is shown by the occurrence of peroxisomal biogenesis disorders (PBDs) in humans. This spectrum of autosomal…”
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Regulation of peroxisomal matrix protein import by ubiquitination by Platta, Harald W., Brinkmeier, Rebecca, Reidick, Christina, Galiani, Silvia, Clausen, Mathias P., Eggeling, Christian

“…Peroxisomes are organelles that play an important role in many cellular tasks. The functionality of peroxisomes depends on the proper import of their matrix…”
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The class III phosphatidylinositol 3-kinase Vps34 in Saccharomyces cerevisiae by Reidick, Christina, Boutouja, Fahd, Platta, Harald W

“…The class III phosphatidylinositol 3-kinase Vps34 (vacuolar protein sorting 34) catalyzes for the formation of the signaling lipid…”
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Regulation of peroxisome dynamics by phosphorylation by Oeljeklaus, Silke, Schummer, Andreas, Mastalski, Thomas, Platta, Harald W., Warscheid, Bettina

“…Peroxisomes are highly dynamic organelles that can rapidly change in size, abundance, and protein content in response to alterations in nutritional and other…”
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Import of proteins into the peroxisomal matrix by Hasan, Sohel, Platta, Harald W, Erdmann, Ralf

“…Peroxisomes constitute a dynamic compartment in all nucleated cells. They fulfill diverse metabolic tasks in response to environmental changes and cellular…”
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Pex2 and Pex12 Function as Protein-Ubiquitin Ligases in Peroxisomal Protein Import by Platta, Harald W., El Magraoui, Fouzi, Bäumer, Bastian E., Schlee, Daniel, Girzalsky, Wolfgang, Erdmann, Ralf

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The peroxisomal protein import machinery by Platta, Harald W., Erdmann, Ralf

“…Peroxisomes are unique organelles whose physiological functions vary depending on the cellular environment or metabolic and developmental state of the…”
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Cysteine-specific ubiquitination protects the peroxisomal import receptor Pex5p against proteasomal degradation by Schwartzkopff, Benjamin, Platta, Harald W, Hasan, Sohel, Girzalsky, Wolfgang, Erdmann, Ralf

“…Peroxisomal matrix protein import is mediated by dynamic import receptors, which cycle between the peroxisomal membrane and the cytosol. Proteins with a type 1…”
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Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling by Platta, Harald W, Magraoui, Fouzi El, Schlee, Daniel, Grunau, Silke, Girzalsky, Wolfgang, Erdmann, Ralf

“…Pex5p, which is the import receptor for peroxisomal matrix proteins harboring a type I signal sequence (PTS1), is mono- and polyubiquitinated in Saccharomyces…”
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Ubiquitination of the peroxisomal import receptor Pex5p by Platta, Harald W, Girzalsky, Wolfgang, Erdmann, Ralf

“…Proteins harbouring a peroxisomal targeting signal of type 1 (PTS1) are recognized by the import receptor Pex5p in the cytosol which directs them to a docking…”
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Autophagy Stimulus-Dependent Role of the Small GTPase Ras2 in Peroxisome Degradation by Boutouja, Fahd, Platta, Harald W

“…The changing accessibility of nutrient resources induces the reprogramming of cellular metabolism in order to adapt the cell to the altered growth conditions…”
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Functional role of the AAA peroxins in dislocation of the cycling PTS1 receptor back to the cytosol by Erdmann, Ralf, Platta, Harald W, Grunau, Silke, Rosenkranz, Katja, Girzalsky, Wolfgang

“…Peroxisomal import receptors bind their cargo proteins in the cytosol and target them to docking and translocation machinery at the peroxisomal membrane…”
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The cytosolic domain of Pex22p stimulates the Pex4p-dependent ubiquitination of the PTS1-receptor by El Magraoui, Fouzi, Schrötter, Andreas, Brinkmeier, Rebecca, Kunst, Lena, Mastalski, Thomas, Müller, Thorsten, Marcus, Katrin, Meyer, Helmut E, Girzalsky, Wolfgang, Erdmann, Ralf, Platta, Harald W

“…Peroxisomal biogenesis is an ubiquitin-dependent process because the receptors required for the import of peroxisomal matrix proteins are controlled via their…”
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Endocytosis and signaling by Platta, Harald W, Stenmark, Harald

“…Highlights ► Receptor signaling can occur at endosomes ► Endosomal signaling can have different outputs than signaling at the plasma membrane ► Distinct…”
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Molecular basis of peroxisomal biogenesis disorders caused by defects in peroxisomal matrix protein import by Nagotu, Shirisha, Kalel, Vishal C., Erdmann, Ralf, Platta, Harald W.

“…Peroxisomal biogenesis disorders (PBDs) represent a spectrum of autosomal recessive metabolic disorders that are collectively characterized by abnormal…”
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Distinct Ubiquitination Cascades Act on the Peroxisomal Targeting Signal Type 2 Co‐receptor Pex18p by El Magraoui, Fouzi, Brinkmeier, Rebecca, Schrötter, Andreas, Girzalsky, Wolfgang, Müller, Thorsten, Marcus, Katrin, Meyer, Helmut E., Erdmann, Ralf, Platta, Harald W.

“…Peroxisomal matrix protein import is facilitated by cycling receptors that recognize their cargo proteins in the cytosol by a peroxisomal targeting sequence…”
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