Search Results - "Plate, K. H."

Serum GFAP is a diagnostic marker for glioblastoma multiforme by Jung, C. S., Foerch, C., Schänzer, A., Heck, A., Plate, K. H., Seifert, V., Steinmetz, H., Raabe, A., Sitzer, M.

“…A serum marker for malignant cerebral astrocytomas could improve both differential diagnosis and clinical management of brain tumour patients. To evaluate…”
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CD74 regulates complexity of tumor cell HLA class II peptidome in brain metastasis and is a positive prognostic marker for patient survival by Zeiner, P S, Zinke, J, Kowalewski, D J, Bernatz, S, Tichy, J, Ronellenfitsch, M W, Thorsen, F, Berger, A, Forster, M T, Muller, A, Steinbach, J P, Beschorner, R, Wischhusen, J, Kvasnicka, H M, Plate, K H, Stefanović, S, Weide, B, Mittelbronn, M, Harter, P N

“…Despite multidisciplinary local and systemic therapeutic approaches, the prognosis for most patients with brain metastases is still dismal. The role of…”
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Mechanisms of Angiogenesis in the Brain by Plate, Karl H

“…SUMMARYBrain angiogenesis is a tightly controlled process that is regulated by neuroectodermal derived growth factors that bind to tyrosine kinase receptors…”
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Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis by PLATE, K. H, BREIER, G, MILLAUER, B, ULLRICH, A, RISAU, W

“…We have recently shown that vascular endothelial growth factor (VEGF) is produced by human malignant glioma cells and acts on tumor endothelial cells, which…”
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Cell Type-Specific Expression of Angiopoietin-1 and Angiopoietin-2 Suggests a Role in Glioblastoma Angiogenesis by Stratmann, Astrid, Risau, Werner, Plate, Karl H.

“…Glioblastomas are highly vascular tumors which overexpress the angiogenesis factor vascular endothelial growth factor (VEGF). VEGF and its receptors, VEGF-R1…”
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Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity by Baumgarten, P., Harter, P. N., Tönjes, M., Capper, D., Blank, A.-E., Sahm, F., von Deimling, A., Kolluru, V., Schwamb, B., Rabenhorst, U., Starzetz, T., Kögel, D., Rieker, R. J., Plate, K. H., Ohgaki, H., Radlwimmer, B., Zörnig, M., Mittelbronn, M.

“…Aims The Far Upstream Element [FUSE] Binding Protein 1 (FUBP1) regulates target genes, such as the cell cycle regulators MYC and p21. FUBP1 is up‐regulated in…”
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Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas by WIZIGMANN-VOOS, S, BREIER, G, RISAU, W, PLATE, K. H

“…Capillary hemangioblastoma is the most frequent manifestation of the autosomal dominantly inherited von Hippel-Lindau (VHL) disease but also presents as a…”
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VEGF in brain tumors by Machein, M R, Plate, K H

“…Vascular endothelial growth factor (VEGF) is a regulator of angiogenesis, vasculogenesis and vascular permeability. In this contribution, molecular and…”
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Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo by Plate, Karl H, Breier, Georg, Weich, Herbert A, Risau, Werner

“…Clinical and experimental studies suggest that angiogenesis is a prerequisite for solid tumour growth. Several growth factors with mitogenic or chemotactic…”
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Expression of vascular endothelial growth factor and its receptors in human renal ontogenesis and in adult kidney by Simon, M, Gröne, H J, Jöhren, O, Kullmer, J, Plate, K H, Risau, W, Fuchs, E

“…Vascular endothelial growth factor (VEGF) may modulate vascular permeability, chemotaxis for monocytes, and protease activity. In addition, VEGF may play a…”
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Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system by KREMER, C, BREIER, G, RISAU, W, PLATE, K. H

“…Vascular endothelial growth factor (VEGF) and its tyrosine kinase receptors VEGFR-1 (flt-1) and VEGFR-2 (flk-1/KDR) are key mediators of physiological and…”
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Angiogenesis in malignant gliomas by Plate, K H, Risau, W

“…One event that accompanies glioma progression is the upregulation of angiogenesis. Low-grade gliomas are moderately vascularized tumors whereas high-grade…”
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Dominant-negative inhibition of Flk-1 suppresses the growth of many tumor types in vivo by MILLAUER, B, LONGHI, M. P, PLATE, K. H, SHAWVER, L. K, RISAU, W, ULLRICH, A, STRAWN, L. M

“…Angiogenesis, the sprouting of new blood vessels from existing vessels, occurs in many physiological and pathological processes, including embryonic…”
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Vascular endothelial growth factor and glioma angiogenesis: coordinate induction of VEGF receptors, distribution of VEGF protein and possible in vivo regulatory mechanisms by Plate, K H, Breier, G, Weich, H A, Mennel, H D, Risau, W

“…We have previously suggested that tumor angiogenesis in human gliomas is regulated by a paracrine mechanism involving vascular endothelial growth factor (VEGF)…”
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Xanthogranuloma of the sellar region by Jung, C S, Schänzer, A, Hattingen, E, Plate, K H, Seifert, V

“…The incidence of diagnosed xanthogranuloma of the sellar region is very low [1, 2, 5, 6]. We report about two cases 1) in a 57-year-old female and 2) in a…”
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Up-regulation of vascular endothelial growth factor expression in a rat glioma is conferred by two distinct hypoxia-driven mechanisms by DAMERT, A, MACHEIN, M, BREIER, G, FUJITA, M. Q, HANAHAN, D, RISAU, W, PLATE, K. H

“…Up-regulation of vascular endothelial growth factor (VEGF) expression is a major event leading to neovascularization in malignant gliomas. Hypoxia is believed…”
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Differential downregulation of vascular endothelial growth factor by dexamethasone in normoxic and hypoxic rat glioma cells by MACHEIN, M. R, KULLMER, J, RÖNICKE, V, MACHEIN, U, KRIEG, M, DAMERT, A, BREIER, G, RISAU, W, PLATE, K. H

“…Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) is a mitogen and chemotactic factor for endothelial cells in vitro and an…”
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Angiogenesis in embryos and ischemic diseases by Breier, G, Damert, A, Plate, K H, Risau, W

“…Angiogenic growth factors and their endothelial receptors are thought to function as major regulators of blood vessel formation. Vascular endothelial growth…”
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Spinocerebellar ataxia type 2 with glial cell cytoplasmic inclusions by Probst-Cousin, S, Acker, T, Epplen, J T, Bergmann, M, Plate, K H, Neundörfer, B, Heuss, D

“…Glial cell cytoplasmic inclusions were identified in a case of spinocerebellar ataxia type 2. These have not been reported before. The inclusions were found in…”
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Gene therapy of malignant glioma: Recent advances in experimental and clinical studies by Sasaki, M., Plate, K. H.

“…Recent advances in molecular tumor biology and gene technology have provided the possibility to treat patients with malignant brain tumors by altering gene…”
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