Sex Differences and Adverse Effects between Chemotherapy and Immunotherapy for Non-Small Cell Lung Cancer

Sex Differences and Adverse Effects between Chemotherapy and Immunotherapy for Non-Small Cell Lung Cancer

: Lung cancer remains the leading cause of cancer mortality in men and women and around the world. Approximately 90% of cases of lung cancer are caused by smoking and the use of tobacco products. However, other factors such as asbestos, air pollution and chronic infections can contribute to pulmonar...

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Published in:Journal of Cancer Vol. 11; no. 11; pp. 3407 - 3415
Main Authors: Tsiouda, Theodora, Sardeli, Chrisanthi, Porpodis, Konstantinos, Pilikidou, Maria, Apostolidis, Georgios, Kyrka, Krystallia, Miziou, Angeliki, Kyrka, Konstantina, Tsingerlioti, Zoi, Papadopoulou, Souzana, Heva, Anta, Koulouris, Charilaos, Giannakidis, Dimitrios, Boniou, Konstantina, Kesisoglou, Isaak, Vagionas, Anastasios, Kosmidis, Christoforos, Sevva, Christina, Papazisis, George, Goganau, Alexandru Marian, Sapalidis, Konstantinos, Tsakiridis, Kosmas, Tryfon, Stavros, Platanas, Michalis, Baka, Sofia, Zaric, Bojan, Perin, Branislav, Petanidis, Savvas, Zarogoulidis, Paul
Format: Journal Article
Language:English
Published: Australia Ivyspring International Publisher Pty Ltd 01-01-2020
Ivyspring International Publisher
Subjects:
Anemia
Asthma
Autoimmune diseases
Cancer therapies
Cardiovascular disease
Chemotherapy
Chronic illnesses
Chronic obstructive pulmonary disease
Diabetes
Gastroesophageal reflux
Gender
Gene expression
Heart failure
Hypertension
Hyperthyroidism
Hypothyroidism
Immunotherapy
Infections
Kinases
Ligands
Lung cancer
Patients
Research Paper
Stroke
Ultrasonic imaging
Womens health
adverse effects
chemotherapy
Lung cancer
immunotherapy
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Summary:: Lung cancer remains the leading cause of cancer mortality in men and women and around the world. Approximately 90% of cases of lung cancer are caused by smoking and the use of tobacco products. However, other factors such as asbestos, air pollution and chronic infections can contribute to pulmonary carcinogenesis. Lung cancer is divided into two broad histological categories, which develop and spread different small cell lung carcinomas and non-small cell lung carcinomas. The treatment options for lung cancer include surgery, radiotherapy, chemotherapy and targeted treatments. Tumor induced immune suppression is vital for malignant progression. Immunotherapies act by strengthening the patient's innate tendency for an immune response and give positive promise to patients with non-small cell lung cancer and small cell lung cancer. Immune checkpoint inhibitors are a new approach to cancer therapies. Just as immune therapies include a new approach to cancer biology, the toxicities associated with these factors have created new challenges in clinical practice. : Patients (218) aged 40-80 years were treated with either chemotherapy or immunotherapy. Their response to treatment and any subsequent adverse drug reactions were studied. : 69% of patients were treated with chemotherapy and 31% were treated with immunotherapy. The type of treatment had a statistically significant effect on the undesirable effects of the treatment. : The type of treatment was statistically significant in responding to the treatment and treatment side effects but not in the rate of death.
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Competing Interests: The authors have declared that no competing interest exists.
ISSN:1837-9664
1837-9664
DOI:10.7150/jca.40196