Search Results - "Plata–Salamán, Carlos R"

Co-crystals as a new approach to multimodal analgesia and the treatment of pain by Almansa, Carmen, Frampton, Christopher S, Vela, Jose Miguel, Whitelock, Steve, Plata-Salaman, Carlos R

“…Pain is highly prevalent, but frequently untreated or under-treated, and health care professionals are faced with a range of treatment challenges. Multimodal…”
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Differential Solution Behavior of the New API–API Co-Crystal of Tramadol–Celecoxib (CTC) versus Its Constituents and Their Combination by Port, Adriana, Almansa, Carmen, Enrech, Raquel, Bordas, Magda, Plata-Salamán, Carlos R

“…Co-crystal of tramadol–celecoxib (CTC) is a novel active pharmaceutical ingredient API–API co-crystal formed by an intrinsic 1:1 molecular ratio of…”
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Discovery of EST73502, a Dual μ‑Opioid Receptor Agonist and σ1 Receptor Antagonist Clinical Candidate for the Treatment of Pain by García, Mónica, Virgili, Marina, Alonso, Mònica, Alegret, Carles, Farran, Joan, Fernández, Begoña, Bordas, Magda, Pascual, Rosalia, Burgueño, Javier, Vidal-Torres, Alba, Fernández de Henestrosa, Antonio R, Ayet, Eva, Merlos, Manuel, Vela, Jose Miguel, Plata-Salamán, Carlos R, Almansa, Carmen

“…The synthesis and pharmacological activity of a new series of 4-alkyl-1-oxa-4,9-diazaspiro[5.5]­undecane derivatives as potent dual ligands for the σ1 receptor…”
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Central nervous system mechanisms contributing to the cachexia–anorexia syndrome by Plata-Salamán, Carlos R

“…The cachexia–anorexia syndrome occurs in chronic pathophysiologic processes including cancer, infection with human immunodeficiency virus, bacterial and…”
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Co-crystal of Tramadol Hydrochloride–Celecoxib (ctc): A Novel API–API Co-crystal for the Treatment of Pain by Almansa, Carmen, Mercè, Ramon, Tesson, Nicolas, Farran, Joan, Tomàs, Jaume, Plata-Salamán, Carlos R.

“…We have identified a co-crystal of tramadol hydrochloride–celecoxib (ctc; E-58425/MR308), a novel active pharmaceutical ingredient (API)–API co-crystal formed…”
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Biomarker discovery and validation: technologies and integrative approaches by Ilyin, Sergey E., Belkowski, Stanley M., Plata-Salamán, Carlos R.

“…The emerging field of biomarkers has applications in the diagnosis, staging, prognosis and monitoring of disease progression, as well as in the monitoring of…”
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Hypothalamus and the Control of Feeding: Fifteen Decades of Direct Association by Plata-Salamán, Carlos R.

“…Anand and Brobeck[1] also stated (page 137) “This particular lateral area of the hypothalamus not only contains … cells … but in addition has in it a large…”
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Cytokine-Induced Anorexia: Behavioral, Cellular, and Molecular Mechanisms by PLATA-SALAMÁN, CARLOS R.

“…Cytokines induce anorexia. Recent issues concerning mechanistic aspects are: (1) Cytokines induce anorexia through different modes of behavioral action, that…”
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Discovery of EST73502, a Dual μ-Opioid Receptor Agonist and σ 1 Receptor Antagonist Clinical Candidate for the Treatment of Pain by García, Mónica, Virgili, Marina, Alonso, Mònica, Alegret, Carles, Farran, Joan, Fernández, Begoña, Bordas, Magda, Pascual, Rosalia, Burgueño, Javier, Vidal-Torres, Alba, Fernández de Henestrosa, Antonio R, Ayet, Eva, Merlos, Manuel, Vela, Jose Miguel, Plata-Salamán, Carlos R, Almansa, Carmen

“…The synthesis and pharmacological activity of a new series of 4-alkyl-1-oxa-4,9-diazaspiro[5.5]undecane derivatives as potent dual ligands for the σ receptor…”
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Brain cytokine mRNAs in anorectic rats bearing prostate adenocarcinoma tumor cells by Plata-Salamán, C R, Ilyin, S E, Gayle, D

“…Cancer is consistently associated with anorexia. The Lobund-Wistar rat model of prostate cancer exhibits clinical manifestations (including anorexia) that…”
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Cytokines and Feeding by Plata-Salaman, Carlos R

“…Carlos R. Plata-Salamán C. R. Plata-Salamán is in the Division of Molecular Biology, School of Life and Health Sciences, University of Delaware, Newark, DE…”
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Feeding status and bacterial LPS-induced cytokine and neuropeptide gene expression in hypothalamus by Gayle, D, Ilyin, S E, Plata-Salamán, C R

“…This study determined the effects of feeding status on basal and lipopolysaccharide (LPS)-stimulated cytokine and neuropeptide gene expression in the…”
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Persistent Borna disease virus infection of neonatal rats causes brain regional changes of mRNAs for cytokines, cytokine receptor components and neuropeptides by Plata-Salamán, Carlos R, Ilyin, Sergey E, Gayle, Dave, Romanovitch, Anna, Carbone, Kathryn M

“…Borna disease virus (BDV) replicates in brain cells. The neonatally infected rat with BDV exhibits developmental-neuromorphological abnormalities, neuronal…”
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Ingestive behavior and obesity by Plata-Salamán, Carlos R

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Taste in the Monkey Cortex by Scott, Thomas R, Plata-Salamán, Carlos R

“…The sense of taste in humans differs substantially from that of rodents, from which a preponderance of gustatory electrophysiology derives. To establish a more…”
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Pro-inflammatory and anti-inflammatory cytokine mRNA induction in the periphery and brain following intraperitoneal administration of bacterial lipopolysaccharide by Turrin, Nicolas P, Gayle, Dave, Ilyin, Sergey E, Flynn, Mark C, Langhans, Wolfgang, Schwartz, Gary J, Plata-Salamán, Carlos R

“…Gram-negative bacteria-derived lipopolysaccharide (LPS or endotoxin) is known to play an important role in immune and neurological manifestations during…”
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Disordered food intake and obesity in rats lacking cholecystokinin A receptors by Moran, T.H, Katz, L.F, Plata-Salaman, C.R, Schwartz, G.J

“…Otsuka Long-Evans Tokushima Fatty (OLETF) rats develop obesity, hyperglycemia, and non-insulin-dependent diabetes mellitus and do not express cholecystokinin A…”
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Cytokine–cytokine interactions and the brain by Turrin, Nicolas P, Plata-Salamán, Carlos R

“…Cytokine–cytokine interactions play a role in health and are crucial during immunological and inflammatory responses in disease. Cytokine interactions can…”
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Brain mechanisms in cytokine-induced anorexia by R. Plata-Salamán, Carlos

“…Our research focuses on the mechanisms underlying cytokine action in the central nervous system (CNS) using an integrative and multidisciplinary strategy…”
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Mode of action of OB protein (leptin) on feeding by Flynn, M.C, Scott, T.R, Pritchard, T.C, Plata-Salaman, C.R

“…OB protein (leptin) decreases food intake in a variety of species. Here we investigated the effects of the intracerebroventricular administration of…”
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