Search Results - "Plata, Daniel J"

A Facile Method for the Preparation of MOM-Protected Carbamates by Barnes, David M, Barkalow, Jufang, Plata, Daniel J

“…A novel method for the preparation of MOM-protected carbamates is described that avoids the use of MOM-Cl, a regulated carcinogen. The two-step, one-pot…”
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Synthesis of the Quinolone ABT-492:  Crystallizations for Optimal Processing by Haight, Anthony R, Ariman, Sema Z, Barnes, David M, Benz, Nancy J, Gueffier, Francoix X, Henry, Rodger F, Hsu, Margaret C, Lee, Elaine C, Morin, Larry, Pearl, Kurt B, Peterson, Matthew J, Plata, Daniel J, Willcox, David R

“…ABT-492 has been under development at Abbott Laboratories as a quinolone antibiotic. A convergent syntheses was utilized to prepare the compound on a…”
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Synthesis of HIV Protease Inhibitor ABT-378 (Lopinavir) by Stoner, Eric J, Cooper, Arthur J, Dickman, Daniel A, Kolaczkowski, Lawrence, Lallaman, John E, Liu, Jih-Hua, Oliver-Shaffer, Patricia A, Patel, Ketan M, Paterson, Joseph B, Plata, Daniel J, Riley, David A, Sham, Hing. L, Stengel, Peter J, Tien, Jien-Heh J

“…A large scale process for the synthesis of HIV protease inhibitor candidate ABT-378 has been developed which utilizes an intermediate common to the synthesis…”
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Efficient and general asymmetric syntheses of ( R)-chroman-4-amine salts by Voight, Eric A., Daanen, Jerome F., Hannick, Steven M., Shelat, Bhadra H., Kerdesky, Francis A., Plata, Daniel J., Kort, Michael E.

“…Starting from a variety of substituted chroman-4-ones, a highly enantioselective CBS reduction using in situ-generated B–H catalyst gave ( S)-chroman-4-ols…”
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Chlorination at the 8-Position of a Functionalized Quinolone and the Synthesis of Quinolone Antibiotic ABT-492 by Barnes, David M, Christesen, Alan C, Engstrom, Kenneth M, Haight, Anthony R, Hsu, Margaret C, Lee, Elaine C, Peterson, Matthew J, Plata, Daniel J, Raje, Prasad S, Stoner, Eric J, Tedrow, Jason S, Wagaw, Seble

“…The total synthesis of quinolone antibiotic ABT-492 has been achieved in 67% yield over nine steps from 2,4,5-trifluorobenzoic acid. The highlights of this…”
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Total synthesis of (+)-18-deoxynargenicin A1 by Plata, Daniel J, Kallmerten, James

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Allylation of Erythromycin Derivatives:  Introduction of Allyl Substituents into Highly Hindered Alcohols by Stoner, Eric J, Peterson, Matthew J, Allen, Michael S, DeMattei, John A, Haight, Anthony R, Leanna, M. Robert, Patel, Subhash R, Plata, Daniel J, Premchandran, Ramiya H, Rasmussen, Michael

“…Functionalized erythromycin 9-oxime derivatives are 6-O-allylated under mild conditions using substituted allyl tert-butyl carbonates under palladium(0)…”
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Efficient Route to 1-Dimethylsulfamoyl-4-iodoimidazole, Isomerisation of 1-Dimethylsulfamoyl-5-iodoimidazole to 1-Dimethylsulfamoyl-4-iodoimidazole by H. Premchandran, Ramiya, Bhagavatula, Lakshmi, J. Plata, Daniel, A. King, Steven, E. Morton, Howard

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Synthesis and Pharmacological Characterization of 3-[2-((3aR,9bR)-cis-6-Methoxy- 2,3,3a,4,5,9b-hexahydro-1H- benz[e]isoindol-2-yl)ethyl]pyrido[3‘,4‘:4,5]thieno[3,2-d]pyrimidine- 2,4(1H,3H)-dione (A-131701):  A Uroselective α1A Adrenoceptor Antagonist for the Symptomatic Treatment of Benign Prostatic Hyperplasia by Meyer, Michael D, Altenbach, Robert J, Basha, Fatima Z, Carroll, William A, Drizin, Irene, Elmore, Steven W, Ehrlich, Paul P, Lebold, Suzanne A, Tietje, Karin, Sippy, Kevin B, Wendt, Michael D, Plata, Daniel J, Plagge, Fred, Buckner, Steven A, Brune, Michael E, Hancock, Arthur A, Kerwin, James F

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Synthetic studies of the nargenicins. Introduction of the C14-C19 side chain by diastereoselective [2,3] Wittig rearrangement of a tertiary allylic ether by Rossano, Lucius T, Plata, Daniel J, Kallmerten, James

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A general synthesis of N-aryl- and N-alkyl-2-aminobenzoxazoles by Tian, Zhenping, Plata, Daniel J., Wittenberger, Steven J., Bhatia, Ashok V.

“…An efficient and practical synthetic procedure is described for the preparation of a variety of N-substituted aryl- and alkyl-2-aminobenzoxazoles. This new…”
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Synthetic Studies of the Nargenicins. 2. Synthesis of the "Northern Half" of Nargenicin A1 by Kallmerten, James, J. Plata, Daniel

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The synthesis of ketolide antibiotic ABT-773 (cethromycin) by Plata, Daniel J., Leanna, M. Robert, Rasmussen, Michael, McLaughlin, Maureen A., Condon, Steven L., Kerdesky, Francis A.J., King, Steven A., Peterson, Matthew J., Stoner, Eric J., Wittenberger, Steven J.

“…A practical and efficient synthesis of ketolide antibiotic cethromycin (ABT-773) ( 1 ) is described. An effective protection strategy allows high yielding,…”
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Synthesis of A-79175: a second generation 5-lipoxygenase inhibitor by Dickman, Daniel A., Ku, Yi-Yin, Morton, Howard E., Chemburkar, Sanjay R., Patel, Hemantkumar H., Thomas, Albert, Plata, Daniel J., Sawick, David P.

“…A convergent, high yielding, and scalable synthesis of A-79175, with a key step involving a mild and efficient CuPd catalyzed coupling reaction of a terminal…”
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Synthesis and Pharmacological Characterization of 3-[2-((3a R ,9b R )- cis -6-Methoxy- 2,3,3a,4,5,9b-hexahydro-1 H - benz[ e ]isoindol-2-yl)ethyl]pyrido[3‘,4‘:4,5]thieno[3,2- d ]pyrimidine- 2,4(1 H ,3 H )-dione (A-131701):  A Uroselective α 1A Adrenoceptor Antagonist for the Symptomatic Treatment of Benign Prostatic Hyperplasia by Meyer, Michael D., Altenbach, Robert J., Basha, Fatima Z., Carroll, William A., Drizin, Irene, Elmore, Steven W., Ehrlich, Paul P., Lebold, Suzanne A., Tietje, Karin, Sippy, Kevin B., Wendt, Michael D., Plata, Daniel J., Plagge, Fred, Buckner, Steven A., Brune, Michael E., Hancock, Arthur A., Kerwin, James F.

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