Search Results - "Plasterk, Ronald H. A."

The Diverse Functions of MicroRNAs in Animal Development and Disease by Kloosterman, Wigard P., Plasterk, Ronald H.A.

“…MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization of mRNAs. While hundreds of miRNAs have been found, only a few have…”
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Targeted inhibition of miRNA maturation with morpholinos reveals a role for miR-375 in pancreatic islet development by Kloosterman, Wigard P, Lagendijk, Anne K, Ketting, René F, Moulton, Jon D, Plasterk, Ronald H A

“…Several vertebrate microRNAs (miRNAs) have been implicated in cellular processes such as muscle differentiation, synapse function, and insulin secretion. In…”
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MicroRNA Expression in Zebrafish Embryonic Development by Wienholds, Erno, Kloosterman, Wigard P, Miska, Eric, Alvarez-Saavedra, Ezequiel, Berezikov, Eugene, de Bruijn, Ewart, Horvitz, H. Robert, Kauppinen, Sakari, Plasterk, Ronald H. A

“…MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can regulate gene expression by base-pairing to partially complementary…”
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Processing of primary microRNAs by the microprocessor complex by Denli, A.M, Tops, B.B.J, Plasterk, R.H.A, Ketting, R.F, Hannon, G.J

“…Mature microRNAs (miRNAs) are generated via a two-step processing pathway to yield approximately 22-nucleotide small RNAs that regulate gene expression at the…”
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Diversity of microRNAs in human and chimpanzee brain by Plasterk, Ronald H A, Berezikov, Eugene, Thuemmler, Fritz, van Laake, Linda W, Kondova, Ivanela, Bontrop, Ronald, Cuppen, Edwin

“…We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of…”
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Transposon silencing in the Caenorhabditis elegans germ line by natural RNAi by Plasterk, Ronald H. A, Sijen, Titia

“…Transposable elements are stretches of DNA that can move and multiply within the genome of an organism. The Caenorhabditis elegans genome contains multiple Tc1…”
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Secondary siRNAs Result from Unprimed RNA Synthesis and Form a Distinct Class by Sijen, Titia, Steiner, Florian A, Thijssen, Karen L, Plasterk, Ronald H.A

“…In Caenorhabditis elegans, an effective RNA interference (RNAi) response requires the production of secondary short interfering RNAs (siRNAs) by RNA-directed…”
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RNA Silencing: The Genome's Immune System by Plasterk, Ronald H A

“…Genomes are databases sensitive to invasion by viruses. In recent years, a defense mechanism has been discovered, which turns out to be conserved among…”
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Mapping determinants of gene expression plasticity by genetical genomics in C. elegans by Li, Yang, Alvarez, Olga Alda, Gutteling, Evert W, Tijsterman, Marcel, Fu, Jingyuan, Riksen, Joost A G, Hazendonk, Esther, Prins, Pjotr, Plasterk, Ronald H A, Jansen, Ritsert C, Breitling, Rainer, Kammenga, Jan E

“…Recent genetical genomics studies have provided intimate views on gene regulatory networks. Gene expression variations between genetically different…”
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Genome-wide RNAi of C. elegans using the hypersensitive rrf-3 strain reveals novel gene functions by Simmer, Femke, Moorman, Celine, van der Linden, Alexander M, Kuijk, Ewart, van den Berghe, Peter V E, Kamath, Ravi S, Fraser, Andrew G, Ahringer, Julie, Plasterk, Ronald H A

“…RNA-mediated interference (RNAi) is a method to inhibit gene function by introduction of double-stranded RNA (dsRNA). Recently, an RNAi library was constructed…”
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Target-Selected Inactivation of the Zebrafish rag1 Gene by Wienholds, Erno, Schulte-Merker, Stefan, Walderich, Brigitte, Ronald H. A. Plasterk

“…The zebrafish has become a favorite organism for genetic analysis of vertebrate development, but methods for generating mutants by reverse genetic approaches…”
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Differences in Vertebrate MicroRNA Expression by Ason, Brandon, Darnell, Diana K., Wittbrodt, Beate, Berezikov, Eugene, Kloosterman, Wigard P., Wittbrodt, Jochen, Antin, Parker B., Plasterk, Ronald H. A.

“…MicroRNAs (miRNAs) attenuate gene expression by means of translational inhibition and mRNA degradation. They are abundant, highly conserved, and predicted to…”
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MicroRNAs show a wide diversity of expression profiles in the developing and mature central nervous system by Kapsimali, Marika, Kloosterman, Wigard P, de Bruijn, Ewart, Rosa, Frederic, Plasterk, Ronald H A, Wilson, Stephen W

“…MicroRNA (miRNA) encoding genes are abundant in vertebrate genomes but very few have been studied in any detail. Bioinformatic tools allow prediction of miRNA…”
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A Caenorhabditis elegans Wild Type Defies the Temperature-Size Rule Owing to a Single Nucleotide Polymorphism in tra-3 by Kammenga, J.E, Doroszuk, A, Riksen, J.A.G, Hazendonk, E, Spiridon, L, Petrescu, A.J, Tijsterman, M, Plasterk, R.H.A, Bakker, J

“…Ectotherms rely for their body heat on surrounding temperatures. A key question in biology is why most ectotherms mature at a larger size at lower…”
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THE GENETICS OF RNA SILENCING by Tijsterman, Marcel, Ketting, René F, Plasterk, Ronald H. A

“…Although initially recognized as a handy tool to reduce gene expression, RNA silencing, triggered by double-stranded RNA molecules, is now recognized as a…”
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A library of Neo Open Reading Frame peptides (NOPs) as a sustainable resource of common neoantigens in up to 50% of cancer patients by Koster, Jan, Plasterk, Ronald H. A.

“…Somatic mutations in cancer can result in neoantigens against which patients can be vaccinated. The quest for tumor specific neoantigens has yielded no targets…”
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C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging by van Ham, Tjakko J, Thijssen, Karen L, Breitling, Rainer, Hofstra, Robert M W, Plasterk, Ronald H A, Nollen, Ellen A A

“…Inclusions in the brain containing alpha-synuclein are the pathological hallmark of Parkinson's disease, but how these inclusions are formed and how this links…”
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RNA Helicase MUT-14-Dependent Gene Silencing Triggered in C. elegans by Short Antisense RNAs by Tijsterman, Marcel, Ketting, René F., Okihara, Kristy L., Sijen, Titia, Ronald H. A. Plasterk

“…Posttranscriptional gene silencing in Caenorhabditis elegans results from exposure to double-stranded RNA (dsRNA), a phenomenon designated as RNA interference…”
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A genetic link between co-suppression and RNA interference in C. elegans by Plasterk, Ronald H. A, Ketting, René F

“…Originally discovered in plants, the phenomenon of co-suppression by transgenic DNA has since been observed in many organisms from fungi to animals:…”
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The microRNA-producing enzyme Dicer1 is essential for zebrafish development by Plasterk, Ronald H A, Wienholds, Erno, Koudijs, Marco J, van Eeden, Freek J M, Cuppen, Edwin

“…MicroRNAs (miRNAs) are produced by the Dicer1 enzyme; the role of Dicer1 in vertebrate development is unknown. Here we report target-selected inactivation of…”
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