Search Results - "Plant, Leigh D"

Two‐pore domain potassium channels: emerging targets for novel analgesic drugs: IUPHAR Review 26 by Gada, Kirin, Plant, Leigh D

“…Chronic pain is a debilitating and increasingly common medical problem with few effective treatments. In addition to the direct and indirect economic burden of…”
Get full text

PIP2 regulation of TRPC5 channel activation and desensitization by Ningoo, Mehek, Plant, Leigh D., Greka, Anna, Logothetis, Diomedes E.

“…Transient receptor potential canonical type 5 (TRPC5) ion channels are expressed in the brain and kidney and have been identified as promising therapeutic…”
Get full text

Hypoxia Produces Pro-arrhythmic Late Sodium Current in Cardiac Myocytes by SUMOylation of NaV1.5 Channels by Plant, Leigh D., Xiong, Dazhi, Romero, Jesus, Dai, Hui, Goldstein, Steve A.N.

“…Acute cardiac hypoxia produces life-threatening elevations in late sodium current (ILATE) in the human heart. Here, we show the underlying mechanism: hypoxia…”
Get full text

Individual IKs channels at the surface of mammalian cells contain two KCNE1 accessory subunits by Plant, Leigh D, Xiong, Dazhi, Dai, Hui, Goldstein, Steve A N

“…KCNE1 (E1) β-subunits assemble with KCNQ1 (Q1) voltage-gated K(+) channel α-subunits to form IKslow (IKs) channels in the heart and ear. The number of E1…”
Get full text

Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation by Jansen, Leslie-Anne R, Welch, Meghyn A, Plant, Leigh D, Baro, Deborah J

“…Post-translational SUMOylation of nuclear and cytosolic proteins maintains homeostasis in eukaryotic cells and orchestrates programmed responses to changes in…”
Get full text

SUMOylation of NaV1.2 channels regulates the velocity of backpropagating action potentials in cortical pyramidal neurons by Kotler, Oron, Khrapunsky, Yana, Shvartsman, Arik, Dai, Hui, Plant, Leigh D, Goldstein, Steven AN, Fleidervish, Ilya

“…Voltage-gated sodium channels located in axon initial segments (AIS) trigger action potentials (AP) and play pivotal roles in the excitability of cortical…”
Get full text

SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons by Plant, Leigh D, Zuniga, Leandro, Araki, Dan, Marks, Jeremy D, Goldstein, Steve A N

“…The standing outward K(+) current (IKso) governs the response of cerebellar granule neurons to natural and medicinal stimuli including volatile anesthetics. We…”
Get more information

Alternative Translation Initiation in Rat Brain Yields K2P2.1 Potassium Channels Permeable to Sodium by Thomas, Dierk, Plant, Leigh D., Wilkens, Christina M., McCrossan, Zoe A., Goldstein, Steve A.N.

“…K2P channels mediate potassium background currents essential to central nervous system function, controlling excitability by stabilizing membrane potential…”
Get full text

Sumoylation Silences the Plasma Membrane Leak K + Channel K2P1 by Rajan, Sindhu, Plant, Leigh D., Rabin, Michael L., Butler, Margaret H., Goldstein, Steve A.N.

“…Reversible, covalent modification with small ubiquitin-related modifier proteins (SUMOs) is known to mediate nuclear import/export and activity of…”
Get full text

One SUMO is sufficient to silence the dimeric potassium channel K2P1 by Plant, Leigh D, Dementieva, Irina S, Kollewe, Astrid, Olikara, Sonia, Marks, Jeremy D, Goldstein, Steve A.N

“…Small ubiquitin modifier 1 (SUMO1) is shown to regulate K2P1 background channels in the plasma membrane (PM) of live mammalian cells. Confocal microscopy…”
Get full text

The Molecular Mechanism of Human Voltage-Dependent Anion Channel 1 Blockade by the Metallofullerenol Gd@C82(OH)22: An In Silico Study by Wang, Xiuxiu, Yang, Nan, Su, Juan, Wu, Chenchen, Liu, Shengtang, Chang, Lei, Plant, Leigh D., Meng, Xuanyu

“…The endohedral metallofullerenol Gd@C82(OH)22 has been identified as a possible antineoplastic agent that can inhibit both the growth and metastasis of cancer…”
Get full text

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons by Plant, Leigh D, Marks, Jeremy D, Goldstein, Steve AN

“…The mechanism for the earliest response of central neurons to hypoxia—an increase in voltage-gated sodium current ( I Na )—has been unknown. Here, we show that…”
Get full text

Optogenetic dephosphorylation of phosphatidylinositol 4,5 bisphosphate in Xenopus laevis oocytes by Gada, Kirin D., Xu, Yu, Winn, Brenda T., Masotti, Meghan, Kawano, Takeharu, Vaananen, Heikki, Plant, Leigh D.

“…Here, we present a protocol for optogenetic dephosphorylation of the phosphoinositide PI(4,5)P2 at the plasma membrane of Xenopus laevis oocytes. We first…”
Get full text

Glo1 inhibitors for neuropsychiatric and anti-epileptic drug development by McMurray, Katherine M J, Distler, Margaret G, Sidhu, Preetpal S, Cook, James M, Arnold, Leggy A, Palmer, Abraham A, Plant, Leigh D

“…Many current pharmacological treatments for neuropsychiatric disorders, such as anxiety and depression, are limited by a delayed onset of therapeutic effect,…”
Get more information

A small molecule inhibitor of SUMO prevents the hypoxia-induced decrease in IK1 current by Chandrashekar, Aishwarya, Gada, Kirin, Xu, Yu, Yang, Yuchen, Plant, Leigh D.

Get full text

Activation of adenosine A2A receptors induces SUMOylation of HIF-1α by Yauch, Anne, Yang, Yuchen, Kawano, Takeharu, Plant, Leigh D.

Get full text

Regulation of Kir2.1 channels by ubiquitin-like modifier proteins by Connolly, Jenna G., Xu, Yu, Kawano, Takeharu, Plant, Leigh D.

Get full text

An optogenetic tool to recruit individual PKC isozymes to the cell surface and promote specific phosphorylation of membrane proteins by Gada, Kirin D., Kawano, Takeharu, Plant, Leigh D., Logothetis, Diomedes E.

“…The PKC family consists of several closely related kinases. These enzymes regulate the function of proteins through the phosphorylation of hydroxyl groups on…”
Get full text

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels by Alexander, Stephen PH, Mathie, Alistair, Peters, John A, Veale, Emma L, Striessnig, Jörg, Kelly, Eamonn, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Sharman, Joanna L, Southan, Christopher, Davies, Jamie A, Aldrich, Richard W, Becirovic, Elvir, Biel, Martin, Catterall, William A, Conner, Alex C, Davies, Paul, Delling, Markus, Virgilio, Francesco Di, Falzoni, Simonetta, George, Chandy, Goldstein, Steve AN, Grissmer, Stephan, Ha, Kotdaji, Hammelmann, Verena, Hanukoglu, Israel, Jarvis, Mike, Jensen, Anders A, Kaczmarek, Leonard K, Kellenberger, Stephan, Kennedy, Charles, King, Brian, Lynch, Joseph W, Perez-Reyes, Edward, Plant, Leigh D, Rash, Lachlan D, Ren, Dejian, Sivilotti, Lucia G, Smart, Trevor G, Snutch, Terrance P, Tian, Jinbin, Van den Eynde, Charlotte, Vriens, Joris, Wei, Aguan D, Winn, Brenda T, Wulff, Heike, Xu, Haoxing, Yue, Lixia, Zhang, Xiaoli, Zhu, Michael

“…The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial publications. The Concise Guide provides concise overviews of the key…”
Get full text

Mechanism of PKCε regulation of cardiac GIRK channel gating by Gada, Kirin D, Chang, Mengmeng, Chandrashekar, Aishwarya, Plant, Leigh D, Noujaim, Sami F, Logothetis, Diomedes E

“…G-protein-gated inwardly rectifying potassium (GIRK) channel activity is regulated by the membrane phospholipid, phosphatidylinositol-4,5-bisphosphate (PI 4,5P…”
Get full text