Search Results - "Plant, J. N"

Measurements of nitrite production in and around the primary nitrite maximum in the central California Current by Santoro, A. E, Sakamoto, C. M, Smith, J. M, Plant, J. N, Gehman, A. L, Worden, A. Z, Johnson, K. S, Francis, C. A, Casciotti, K. L

“…Nitrite (NO2−) is a substrate for both oxidative and reductive microbial metabolism. NO2− accumulates at the base of the euphotic zone in oxygenated,…”
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Receptor-dependent transcriptional activation of cytochrome P4503A genes: induction mechanisms, species differences and interindividual variation in man by Gibson, G. G., Plant, N. J., Swales, K. E., Ayrton, A., El-Sankary, W.

“…1 The importance of CYP3A enzymes in drug metabolism and toxicology has yielded a wealth of information on the structure, function and regulation of this…”
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A long-term, high-resolution record of surface water iron concentrations in the upwelling-driven central California region by Elrod, V. A., Johnson, K. S., Fitzwater, S. E., Plant, J. N.

“…Seven years of observations of surface water iron concentrations in the Monterey Bay region of central California reveal a consistent annual cycle dominated by…”
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NH4‐Digiscan: an in situ and laboratory ammonium analyzer for estuarine, coastal, and shelf waters by Plant, J. N., Johnson, K. S., Needoba, J. A., Coletti, L. J.

“…The NH4‐Digiscan is an in situ analyzer designed for measuring ammonium in estuarine, coastal, and shelf waters at depths of less than 3 m. This wet chemical…”
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Annual Net Community Production of Particulate and Dissolved Organic Carbon From a Decade of Biogeochemical Profiling Float Observations in the Northeast Pacific by Haskell, W. Z., Fassbender, A. J., Long, J. S., Plant, J. N.

“…Carbon export out of the surface ocean via the biological pump is a critical sink for atmospheric carbon dioxide. This process transports organic carbon to the…”
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Regulation of the CYP3A4 Gene by Hydrocortisone and Xenobiotics: Role of the Glucocorticoid and Pregnane X Receptors by EL-SANKARY, W, PLANT, N. J, GIBSON, G. G, MOORE, D. J

“…The molecular mechanisms of regulation of the CYP3A4 gene have been examined in an in vitro reporter gene system, containing −1 kb of the CYP3A4 promoter, in…”
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Continuous sampling of hydrothermal fluids from Loihi Seamount after the 1996 event by Wheat, C. Geoffrey, Jannasch, Hans W., Plant, Josh N., Moyer, Craig L., Sansone, Francis J., McMurtry, Gary M.

“…For at least 9 years prior to July 1996, hydrothermal fluids flowed from Pele's Vents on Loihi Seamount, Hawaii. In July–August 1996 a tectonic‐volcanic event…”
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Iron, Sulfur, and Carbon Diagenesis in Sediments of Tomales Bay, California by Chambers, R. M., Hollibaugh, J. T., Snively, C. S., Plant, J. N.

“…Analysis of 3-m sediment cores revealed that profiles of carbon (C), sulfur (S), and iron (Fe) varied with relative distance from marine and terrestrial…”
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Synergistic interaction between lipid-loading and doxorubicin exposure in Huh7 hepatoma cells results in enhanced cytotoxicity and cellular oxidative stress: implications for acute and chronic care of obese cancer patients by AlGhamdi, S, Leoncikas, V, Plant, K E, Plant, N J

“…There has been a dramatic increase in the number of clinically obese individuals in the last twenty years. This has resulted in an increasingly common scenario…”
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Species-specific induction of cytochrome P-450 4A RNAs : PCR cloning to partial guinea-pig, human and mouse CYP4A cDNAs by BELL, D. R, PLANT, N. J, GILBERT, D. J, COPELAND, N. G, ELCOMBE, C. R, RIDER, C. G, NA, L, BROWN, S, ATEITALLA, I, ACHARYA, S. K, DAVIES, M. H, ELIAS, E, JENKINS, N. A

“…PCR was used to demonstrate the presence of a conserved region and to clone novel members of the cytochrome P-450 4A gene family from guinea pig, human and…”
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The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated by the liver growth agents, phenobarbital and methylclofenapate by PLANT, N. J, HORLEY, N. J, DICKINS, M, HASMALL, S, ELCOMBE, C. R, BELL, D. R

“…The coordinate regulation of DNA synthesis and suppression of apoptosis was investigated in a rat hepatocyte cell culture system which supports high level…”
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The peroxisome proliferators are hepatocyte mitogens in chemically-defined media : glucocorticoid-induced PPARα is linked to peroxisome proliferator mitogenesis by PLANT, N. J, HORLEY, N. J, SAVORY, R. L, ELCOMBE, C. R, GRAY, T. J. B, BELL, D. R

“…Peroxisome proliferator-induced mitogenesis is believed to play a role in hepatocarcinogenesis, but it has not been possible to demonstrate high level…”
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Manganese and iron distributions off central California influenced by upwelling and shelf width by Chase, Zanna, Johnson, Kenneth S., Elrod, Virginia A., Plant, Joshua N., Fitzwater, Steve E., Pickell, Lisa, Sakamoto, Carol M.

“…In July 2002, a combination of underway mapping and discrete profiles revealed significant along-shore variability in the concentrations of manganese and iron…”
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Seawater transport and reaction in upper oceanic basaltic basement: chemical data from continuous monitoring of sealed boreholes in a ridge flank environment by Wheat, C.Geoffrey, Jannasch, Hans W., Kastner, Miriam, Plant, Josh N., DeCarlo, Eric Heinen

“…Osmotically pumped fluid samplers were deployed in four deep-sea boreholes that were drilled during Ocean Drilling Program (ODP) Leg 168 on the eastern flank…”
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Receptor-dependent regulation of the CYP3A4 gene by Gibson, G.Gordon, El-Sankary, Wafaa, Plant, Nick J

“…A CYP3A4 promoter–reporter gene construct has been used to assess the ability of 16 known (in vivo) and putative (in vitro) inducers to transactivate a CYP3A4…”
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Control and Statistical Analysis of in Vitro Reporter Gene Assays by Plant, Nick J., Ogg, Malcolm, Crowder, Martin, Gibson, G.Gordon

“…The use of in vitro gene reporter assays is becoming increasingly widespread in biology and particularly in drug metabolism, where the need for rapid screening…”
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Peroxisome proliferators: species differences in response of primary hepatocyte cultures by Elcombe, C R, Bell, D R, Elias, E, Hasmall, S C, Plant, N J

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Simulation of the PPAR[...]regulome predicts PPAR[...]activation exacerbates the development of hepatic steatosis by Fisher, C P, Khoury, M, Barber, A L, Mazzatti, D J, Plant, N J, Kierzek, A M, Moore, J B

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Development of a dynamic multi-scale, computational model of human hepatic glucose and fructose metabolism by Maldonado, E.M., Tindall, M.J., Plant, N.J., Kierzek, A.M., Moore, J.B.

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Synergistic interaction between lipid-loading and doxorubicin exposure in Huh7 hepatoma cells results in enhanced cytotoxicity and cellular oxidative stress: implications for acute and chronic care of obese cancer patientsElectronic supplementary information (ESI) available. See DOI: 10.1039/c5tx00173k by AlGhamdi, S, Leoncikas, V, Plant, K. E, Plant, N. J

“…There has been a dramatic increase in the number of clinically obese individuals in the last twenty years. This has resulted in an increasingly common scenario…”
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