Search Results - "Plant, Barry J."

The effects of freezing on faecal microbiota as determined using MiSeq sequencing and culture-based investigations by Fouhy, Fiona, Deane, Jennifer, Rea, Mary C, O'Sullivan, Órla, Ross, R Paul, O'Callaghan, Grace, Plant, Barry J, Stanton, Catherine

“…High-throughput sequencing has enabled detailed insights into complex microbial environments, including the human gut microbiota. The accuracy of the…”
Get full text

Individualized approach to elexacaftor/tezacaftor/ivacaftor dosing in cystic fibrosis, in response to self-reported anxiety and neurocognitive adverse events: A case series by Ibrahim, Hisham, Danish, Hammad, Morrissey, David, Deasy, Kevin F, McCarthy, Mairead, Dorgan, James, Fleming, Claire, Howlett, Ciara, Twohig, Sarah, Vagg, Tamara, Murphy, Desmond M, Maher, Michael, Plant, Barry J

“…The prevalence of mental health disorders is high among people with Cystic Fibrosis. The psychological symptoms in CF are associated with poor adherence, worse…”
Get full text

Effects of Ivacaftor in Patients With Cystic Fibrosis Who Carry the G551D Mutation and Have Severe Lung Disease by Barry, Peter J., MBBCh, Plant, Barry J., MD, Nair, Arjun, MBChB, Bicknell, Stephen, MBChB, Simmonds, Nicholas J., MD, Bell, Nicholas J., MBChB, Shafi, Nadia T., MD, Daniels, Thomas, MD, Shelmerdine, Susan, MBBS, Felton, Imogen, MBBS, Gunaratnam, Cedric, MBBCh, Jones, Andrew M., MD, Horsley, Alex R., PhD

“…BACKGROUND The development of ivacaftor represents a significant advance in therapeutics for patients with cystic fibrosis (CF) who carry the G551D mutation…”
Get full text

Microbiota and metabolite profiling reveal specific alterations in bacterial community structure and environment in the cystic fibrosis airway during exacerbation by Twomey, Kate B, Alston, Mark, An, Shi-Qi, O'Connell, Oisin J, McCarthy, Yvonne, Swarbreck, David, Febrer, Melanie, Dow, J Maxwell, Plant, Barry J, Ryan, Robert P

“…Chronic polymicrobial infections of the lung are the foremost cause of morbidity and mortality in cystic fibrosis (CF) patients. The composition of the…”
Get full text

Bacterial cis-2-unsaturated fatty acids found in the cystic fibrosis airway modulate virulence and persistence of Pseudomonas aeruginosa by Twomey, Kate B, O'Connell, Oisin J, McCarthy, Yvonne, Dow, J Maxwell, O'Toole, George A, Plant, Barry J, Ryan, Robert P

“…There is an increasing appreciation of the polymicrobial nature of many bacterial infections such as those associated with cystic fibrosis (CF) and of the…”
Get full text

Management of comorbidities in older patients with cystic fibrosis by Plant, Barry J, Dr, Goss, Christopher H, Prof, Plant, William D, MD, Bell, Scott C, Prof

“…Summary Several key advances have been made in the treatment and management of people with cystic fibrosis in the past two decades. Substantial improvements in…”
Get full text

Creatine kinase levels in asthma patients receiving interleukin-5 therapy by Kavanagh, Grace A., Casey, Deborah, Cusack, Ruth P., Plant, Barry J., Murphy, Desmond M.

Get full text

Considerations for the use of inhaled antibiotics for Pseudomonas aeruginosa in people with cystic fibrosis receiving CFTR modulator therapy by Burgel, Pierre-Régis, Ballmann, Manfred, Drevinek, Pavel, Heijerman, Harry, Jung, Andreas, Mainz, Jochen G, Peckham, Daniel, Plant, Barry J, Schwarz, Carsten, Taccetti, Giovanni, Smyth, Alan

“…The major cause of mortality in people with cystic fibrosis (pwCF) is progressive lung disease characterised by acute and chronic infections, the accumulation…”
Get full text

Real-World clinical outcomes of asthma patients switched from reslizumab to mepolizumab or benralizumab by Walsh, Laura J, Casey, Deborah, Vairamani, Punitha, Arnott, Fiona, Plant, Barry J, Murphy, Desmond M

“…Approximately 3%-10% of asthma patients will remain uncontrolled despite maximum, optimal conventional therapy. Treatment of severe refractory asthma often…”
Get full text

Virtual monitoring in CF - the importance of continuous monitoring in a multi-organ chronic condition by Vagg, Tamara, Deasy, Kevin F, Chapman, Wendy W, Ranganathan, Sarath C, Plant, Barry J, Shanthikumar, Shivanthan

“…Cystic Fibrosis (CF) is a chronic life-limiting condition that affects multiple organs within the body. Patients must adhere to strict medication regimens,…”
Get full text

Eosinophils and COPD Readmission by Thong, Lorraine, MB, O’Driscoll, Michael, MB, Casey, Carmel, BSc, Kennedy, Marcus, MB, FCCP, Plant, Barry J., MB, Henry, Michael T., MB, Murphy, Desmond M., MB, FCCP

Get full text

Biologically Relevant Murine Models of Chronic Pseudomonas aeruginosa Respiratory Infection by Rodgers, Aoife M., Lindsay, Jaime, Monahan, Avril, Dubois, Alice V., Faniyi, Aduragbemi A., Plant, Barry J., Mall, Marcus A., Ekkelenkamp, Miquel B., Elborn, Stuart, Ingram, Rebecca J.

“…Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen and the leading cause of infection in patients with cystic fibrosis (CF). The ability of P…”
Get full text

The Role of Ivacaftor in Severe Cystic Fibrosis in a Patient With the R117H Mutation by Ronan, Nicola J., MBBCh, Fleming, Claire, BSc, O'Callaghan, Grace, PhD, Maher, Michael M., MBBCh, MD, Murphy, Desmond M., MBBCh, PhD, FCCP, Plant, Barry J., MBBCh, MD

“…Cystic fibrosis (CF) conductance transmembrane regulator functions as a chloride (Cl– ) channel in multiple organs, including the lungs. More than 1,800…”
Get full text

Roflumilast in COPD by Worndl, Erin, MB, Hunt, Eoin B., MD, Kennedy, Marcus P., MB, FCCP, Henry, Michael T., MB, Plant, Barry J., MB, Murphy, Desmond M., MB, PhD, FCCP

Get full text

Peri-Lung Transplant Renal Issues in Patients With Cystic Fibrosis by O'Connell, Oisin J., MD, Harrison, Michael J., MD, Murphy, Desmond M., MD, FCCP, Plant, William D., MD, Plant, Barry J., MD

Get full text

VX-659–Tezacaftor–Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles by Davies, Jane C, Moskowitz, Samuel M, Brown, Cynthia, Horsley, Alexander, Mall, Marcus A, McKone, Edward F, Plant, Barry J, Prais, Dario, Ramsey, Bonnie W, Taylor-Cousar, Jennifer L, Tullis, Elizabeth, Uluer, Ahmet, McKee, Charlotte M, Robertson, Sarah, Shilling, Rebecca A, Simard, Christopher, Van Goor, Fredrick, Waltz, David, Xuan, Fengjuan, Young, Tim, Rowe, Steven M

“…This companion article to the VX-445 report shows that VX-659, a new CFTR potentiator, when administered with tezacaftor and ivacaftor improved lung function,…”
Get full text

Telehealth and virtual health monitoring in cystic fibrosis by Vagg, Tamara, Shanthikumar, Shivanthan, Morrissy, David, Chapman, Wendy W., Plant, Barry J., Ranganathan, Sarath

“…At many institutions, the Covid-19 pandemic made it necessary to rapidly change the way services are provided to patients, including those with cystic fibrosis…”
Get full text

Current and emerging comorbidities in cystic fibrosis by Ronan, Nicola J., Elborn, Joseph Stuart, Plant, Barry J.

“…Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed ubiquitously throughout the body. Thus, while respiratory manifestations dominate much…”
Get full text

CORK Study in Cystic Fibrosis: Sustained Improvements in Ultra-Low-Dose Chest CT Scores After CFTR Modulation With Ivacaftor by Ronan, Nicola J, Einarsson, Gisli G, Twomey, Maria, Mooney, Denver, Mullane, David, NiChroinin, Muireann, O'Callaghan, Grace, Shanahan, Fergus, Murphy, Desmond M, O'Connor, Owen J, Shortt, Cathy A, Tunney, Michael M, Eustace, Joseph A, Maher, Michael M, Elborn, J Stuart, Plant, Barry J

“…Ivacaftor produces significant clinical benefit in patients with cystic fibrosis (CF) with the G551D mutation. Prevalence of this mutation at the Cork CF…”
Get full text

Editorial: A future focus on cystic fibrosis in an era of uncertainty despite opportunity by Barry, Peter J., Plant, Barry J.

Get full text