The ‘peptide for life’ initiative in the emergency department study

Aims Natriuretic peptide (NP) uptake varies in Emergency Departments (EDs) across Europe. The ‘Peptide for Life’ (P4L) initiative, led by Heart Failure Association, aims to enhance NP utilization for early diagnosis of heart failure (HF). We tested the hypothesis that implementing an educational cam...

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Published in:	ESC Heart Failure Vol. 11; no. 2; pp. 672 - 680
Main Authors:	Bayes‐Genis, Antoni, Krljanac, Gordana, Zdravković, Marija, Ašanin, Milika, Stojšić‐Milosavljević, Anastazija, Radovanović, Slavica, Kovačević, Tamara Preradović, Selaković, Aleksandar, Milinković, Ivan, Polovina, Marija, Glavaš, Duška, Srbinovska, Elizabeta, Bulatović, Nebojša, Miličić, Davor, Čikeš, Maja, Babić, Zdravko, Šikić, Jozica, Kušljugić, Zumreta, Hudić, Larisa Dizdarević, Arfsten, Henrike, Meems, Laura M.G., Metra, Marco, Rosano, Giuseppe, Seferović, Petar M., Tomic, M., Stankovic, S., Klaric, M., Viduljevic, M., Djordjevic, N., Klac, J., Civric, D., Pejovic, T., Babic, B., Nenezic, T., Radovanovic, Z., Jungic, B., Milovancev, A., Tripunovic, J., Denda, N., Milosavljevic, I., Jankovic, M., Dikovic, B., Zimbakov, Z., Mitevska, I., Kostovski, L., Popadic, V., Radojevic, A., Manojlovic, A., Radovanovic, D., Ivankovic, T., Gajic, U., Stojanovic, M., Marinkovic, D., Stojkovic, J., Stojcic, B., Savic, V., Bogdanovic, M., Sredojevic, M., Blagojevic, N., Radovanovic, M., Tabakovic, L., Borovac, J.A., Meter, M., Parcina, M., Sosic, A., Ivanisevic Dzaja, M., Katic, J., Pasara, V., Hoteit, S., Planinic, Z.
Format:	Journal Article
Language:	English
Published:	England John Wiley and Sons Inc 01-04-2024 Wiley
Subjects:	Access Adoption Awareness Emergency department Natriuretic peptides Original Peptide for life Access Emergency department Peptide for life Awareness Adoption Natriuretic peptides
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Summary:	Aims Natriuretic peptide (NP) uptake varies in Emergency Departments (EDs) across Europe. The ‘Peptide for Life’ (P4L) initiative, led by Heart Failure Association, aims to enhance NP utilization for early diagnosis of heart failure (HF). We tested the hypothesis that implementing an educational campaign in Western Balkan countries would significantly increase NP adoption rates in the ED. Methods and results This registry examined NP adoption before and after implementing the P4L‐ED study across 10 centres in five countries: Bosnia and Herzegovina, Croatia, Montenegro, North Macedonia, and Serbia. A train‐the‐trainer programme was implemented to enhance awareness of NP testing in the ED, and centres without access received point‐of‐care instruments. Differences in NP testing between the pre‐P4L‐ED and post‐P4L‐ED phases were evaluated. A total of 2519 patients were enrolled in the study: 1224 (48.6%) in the pre‐P4L‐ED phase and 1295 (51.4%) in the post‐P4L‐ED phase. NP testing was performed in the ED on 684 patients (55.9%) during the pre‐P4L‐ED phase and on 1039 patients (80.3%) during the post‐P4L‐ED phase, indicating a significant absolute difference of 24.4% (95% CI: 20.8% to 27.9%, P < 0.001). The use of both NPs and echocardiography significantly increased from 37.7% in the pre‐P4L‐ED phase to 61.3% in the post‐P4L‐ED phase. There was an increased prescription of diuretics and SGLT2 inhibitors during the post‐P4L‐ED phase. Conclusions By increasing awareness and providing resources, the utilization of NPs increased in the ED, leading to improved diagnostic accuracy and enhanced patient care.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Correction added on 16 January 2024, after first online publication: Investigators' group name has been added in the author byline in this version.
ISSN:	2055-5822 2055-5822
DOI:	10.1002/ehf2.14625