Search Results - "Planell, N."

Epithelial IL-1R2 acts as a homeostatic regulator during remission of ulcerative colitis by Mora-Buch, R, Dotti, I, Planell, N, Calderón-Gómez, E, Jung, P, Masamunt, M C, Llach, J, Ricart, E, Batlle, E, Panés, J, Salas, A

“…Ulcerative colitis (UC) is a chronic intestinal inflammatory disease that may undergo periods of activity followed by remission. We aimed to identify the…”
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TL1A/TNFSF15 directly induces proinflammatory cytokines, including TNFα, from CD3+CD161+ T cells to exacerbate gut inflammation by Jin, S, Chin, J, Seeber, S, Niewoehner, J, Weiser, B, Beaucamp, N, Woods, J, Murphy, C, Fanning, A, Shanahan, F, Nally, K, Kajekar, R, Salas, A, Planell, N, Lozano, J, Panes, J, Parmar, H, DeMartino, J, Narula, S, Thomas-Karyat, D A

“…Tumor necrosis factor (TNF)-like cytokine 1A (TL1A)/TNF superfamily member 15 (TNFSF15) is a proinflammatory cytokine and TNFα superfamily member that is…”
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Quantifying noise in mass spectrometry and yeast two-hybrid protein interaction detection experiments by Annibale, A., Coolen, A. C. C., Planell-Morell, N.

“…Protein interaction networks (PINs) are popular means to visualize the proteome. However, PIN datasets are known to be noisy, incomplete and biased by the…”
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Targeted lipidomics reveals extensive changes in circulating lipid mediators in patients with acutely decompensated cirrhosis by López-Vicario, Cristina, Checa, Antonio, Urdangarin, Arantxa, Aguilar, Ferran, Alcaraz-Quiles, José, Caraceni, Paolo, Amorós, Alex, Pavesi, Marco, Gómez-Cabrero, David, Trebicka, Jonel, Oettl, Karl, Moreau, Richard, Planell, Núria, Arroyo, Vicente, Wheelock, Craig E., Clària, Joan

“…Acute-on-chronic liver failure (ACLF) is a newly described syndrome, which develops in patients with acute decompensation of cirrhosis, and is characterized by…”
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Uncovering the Cis-Regulatory Program of Early Human B-Cell Commitment and Its Implications in the Pathogenesis of B-Cell Acute Lymphoblastic Leukemia by Planell, Nuria, Martínez-de-Morentin, Xabier, Mouzo, Daniel, Lara-Astiaso, David, Vilas-Zornoza, Amaia, San-Martin, Patxi, Alignani, Diego, Paiva, Bruno, Maillo, Alberto, Kurowska, Aleksandra, Urdangarin, Arantxa, Noori, Peri, Ortega-Legarreta, Asier, Hernaez, Mikel, Lagani, Vincenzo, Kiani, Narsis, Martin Subero, Iñaki I., Ramírez, Ricardo N., Tegner, Jesper, Prosper, Felipe, Gomez-Cabrero, David

“…The early stages of the B-cell system are key for cellular immunity development. The development of functional B cells requires appropriate regulation of…”
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Transcriptomic Analysis Of Extracellular Vesicles For Biomarker Discovery In Peripheral Artery Disease (Pad) by De Pipaon, G. Saenz, David, L., Maillo, A., Vilas, A., Planell, N., Rodriguez, J.A., San Martín, P., Paramo, J.A., Prosper, F., Orbe, J., Gomez-Cabrero, D., Roncal, C.

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Epigenetic clock indicates accelerated aging in glial cells of progressive multiple sclerosis patients by Kular, Lara, Klose, Dennis, Urdánoz-Casado, Amaya, Ewing, Ewoud, Planell, Nuria, Gomez-Cabrero, David, Needhamsen, Maria, Jagodic, Maja

“…BackgroundMultiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease of the central nervous system (CNS) characterized by irreversible…”
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STATegra: Multi-Omics Data Integration - A Conceptual Scheme With a Bioinformatics Pipeline by Planell, Nuria, Lagani, Vincenzo, Sebastian-Leon, Patricia, van der Kloet, Frans, Ewing, Ewoud, Karathanasis, Nestoras, Urdangarin, Arantxa, Arozarena, Imanol, Jagodic, Maja, Tsamardinos, Ioannis, Tarazona, Sonia, Conesa, Ana, Tegner, Jesper, Gomez-Cabrero, David

“…Technologies for profiling samples using different omics platforms have been at the forefront since the human genome project. Large-scale multi-omics data hold…”
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A robust clustering strategy for stratification unveils unique patient subgroups in acutely decompensated cirrhosis by Palomino-Echeverria, Sara, Huergo, Estefania, Ortega-Legarreta, Asier, Uson Raposo, Eva M, Aguilar, Ferran, Peña-Ramirez, Carlos de la, López-Vicario, Cristina, Alessandria, Carlo, Laleman, Wim, Queiroz Farias, Alberto, Moreau, Richard, Fernandez, Javier, Arroyo, Vicente, Caraceni, Paolo, Lagani, Vincenzo, Sánchez-Garrido, Cristina, Clària, Joan, Tegner, Jesper, Trebicka, Jonel, Kiani, Narsis A, Planell, Nuria, Rautou, Pierre-Emmanuel, Gomez-Cabrero, David

“…Patient heterogeneity poses significant challenges for managing individuals and designing clinical trials, especially in complex diseases. Existing…”
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P843 Upadacitinib-induced endoscopic improvement is associated with modulation of pathways involved in Crohn’s disease pathogenesis by Aguilar, D, Planell, N, Panés, J, Lacerda, A, Butler, J, Davis, J W, Salas, A

“…Abstract Background Upadacitinib (UPA; ABT-494) is an oral JAK1 selective inhibitor being investigated to treat Crohn's disease (CD). In a phase 2 study…”
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Non-parametric combination analysis of multiple data types enables detection of novel regulatory mechanisms in T cells of multiple sclerosis patients by Fernandes, Sunjay Jude, Morikawa, Hiromasa, Ewing, Ewoud, Ruhrmann, Sabrina, Joshi, Rubin Narayan, Lagani, Vincenzo, Karathanasis, Nestoras, Khademi, Mohsen, Planell, Nuria, Schmidt, Angelika, Tsamardinos, Ioannis, Olsson, Tomas, Piehl, Fredrik, Kockum, Ingrid, Jagodic, Maja, Tegnér, Jesper, Gomez-Cabrero, David

“…Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system with prominent neurodegenerative components. The triggering and progression of…”
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P838 Effects of microbial metabolites on human intestinal epithelium by Mayorgas, A, Ferrer-Picón, E, Dotti, I, Corraliza, A, Planell, N, Esteller, M, Carrasco, A, Masamunt, M C, Esteve, M, Panés, J, Salas, A

“…Abstract Background The intestinal epithelium is the interface between the microbiota and the underlying host mucosa. Intrinsic genetic as well as acquired…”
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Functional and transcriptomic analysis of extracellular vesicles identifies calprotectin as a new prognostic marker in peripheral arterial disease (PAD) by Saenz-Pipaon, Goren, San Martín, Patxi, Planell, Núria, Maillo, Alberto, Ravassa, Susana, Vilas-Zornoza, Amaia, Martinez-Aguilar, Esther, Rodriguez, José Antonio, Alameda, Daniel, Lara-Astiaso, David, Prosper, Felipe, Paramo, José Antonio, Orbe, Josune, Gomez-Cabrero, David, Roncal, Carmen

“…Peripheral arterial disease (PAD) is associated with a high risk of cardiovascular events and death and is postulated to be a critical socioeconomic cost in…”
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P020 Wnt5b could contribute to regeneration of the epithelium in inflammatory bowel disease by potentiating epithelial mesenchymal transition by Dotti, I., Ferrer-Picόn, E., Planell, N., van Herk, E.H., Cuatrecasas, M., Panés, J., Salas, A.

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P056 Transcriptional profiling of intestinal epithelial organoids derived from paediatric Crohn’s disease patients by Dotti, I, Ferrer-Picón, E, Planell, N, Martín de Carpi, J, Pujol, G, Masamunt, M, Esteller, M, Carrasco, A, Alvarez, L, Tristán, E, Ordás, I, Esteve, M, Ricart, E, Salas, A

“…Abstract Background Crohn’s disease (CD) is a chronic inflammatory bowel disease (IBD) with onset occurring from childhood to late age. Despite a comparable…”
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P025 Transcriptional and molecular pathways activated in mesenteric adipose tissue and intestinal mucosa of Crohn's disease patients by Coope, A., Pascoal, L.B., Silva, F.A.R., Botezelli, J.D., Ayrizono, M.L.S., Milanski, M., Camargo, M.G., Planell, N., Portovedo, M., Dias, C.B., Fagundes, J.J., Leal, R.F.

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DOP070 Endoscopic response to induction therapy with TNF inhibitors is the best predictor of long term mucosal healing in Crohn's disease by Alfaro, I., Masamunt, M., Planell, N., Lόpez-García, A., Castro, J., Gallego, M., Barastegui, R., Giner, A., Vara, A., Salas, A., Ricart, E., Panés, J., Ordás, I.

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P091 Usefulness of transcriptional whole blood biomarkers as a non-invasive surrogate marker of mucosal healing and endoscopic response in ulcerative colitis by Planell, N., Masamunt, M.C., Franco Leal, R., Rodríguez, L., Esteller, M., Lozano, J.J., Ramírez, A., Setsuko Ayrizono, M.d.L., Saddy Rodrigues Coy, C., Alfaro, I., Ordás, I., Visvanathan, S., Ricart, E., Guardiola, J., Panés, J., Salas, A.

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Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation by Ye, Jin, Calvo, Isabel A., Cenzano, Itziar, Vilas, Amaia, Martinez-de-Morentin, Xabier, Lasaga, Miren, Alignani, Diego, Paiva, Bruno, Viñado, Ana C., San Martin-Uriz, Patxi, Romero, Juan P., Quilez Agreda, Delia, Miñana Barrios, Marta, Sancho-González, Ignacio, Todisco, Gabriele, Malcovati, Luca, Planell, Nuria, Saez, Borja, Tegner, Jesper N., Prosper, Felipe, Gomez-Cabrero, David

“…Understanding the regulation of normal and malignant human hematopoiesis requires comprehensive cell atlas of the hematopoietic stem cell (HSC) regulatory…”
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P064 Identification of inflammatory mediators in Crohn's disease patients who are unresponsive to anti-TNF therapy – A transcriptional analysis of intestinal mucosa by Leal, R.F., Planell, N., Kajekar, R., Lozano, J.J., Ordás, I., Dotti, I., Esteller, M., Masamunt, M.C., Parmar, H., Ricart, E., Panés, J., Salas, A.

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