Search Results - "Planagumà, Jesús"
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Ephrin-B2 prevents N-methyl-D-aspartate receptor antibody effects on memory and neuroplasticity
Published in Annals of neurology (01-09-2016)“…Objective To demonstrate that ephrin‐B2 (the ligand of EphB2 receptor) antagonizes the pathogenic effects of patients' N‐methyl‐D‐aspartate receptor (NMDAR)…”
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Clinical and Immunological Features of Opsoclonus-Myoclonus Syndrome in the Era of Neuronal Cell Surface Antibodies
Published in JAMA neurology (01-04-2016)“…Most studies on opsoclonus-myoclonus syndrome (OMS) in adults are based on small case series before the era of neuronal cell surface antibody discovery. To…”
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Human Autoantibodies against the AMPA Receptor Subunit GluA2 Induce Receptor Reorganization and Memory Dysfunction
Published in Neuron (Cambridge, Mass.) (10-10-2018)“…AMPA receptors are essential for fast excitatory transmission in the CNS. Autoantibodies to AMPA receptors have been identified in humans with autoimmune…”
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NMDA Receptor Autoantibodies in Autoimmune Encephalitis Cause a Subunit-Specific Nanoscale Redistribution of NMDA Receptors
Published in Cell reports (Cambridge) (26-06-2018)“…Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe neuropsychiatric disorder mediated by autoantibodies against the GluN1 subunit of the…”
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The diagnosis of anti-LGI1 encephalitis varies with the type of immunodetection assay and sample examined
Published in Frontiers in immunology (15-12-2022)“…Detection of Leucine-rich glioma inactivated 1 (LGI1) antibodies in patients with suspected autoimmune encephalitis is important for diagnostic confirmation…”
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Human CASPR2 Antibodies Reversibly Alter Memory and the CASPR2 Protein Complex
Published in Annals of neurology (01-06-2022)“…Objective The encephalitis associated with antibodies against contactin‐associated proteinlike 2 (CASPR2) is presumably antibody‐mediated, but the antibody…”
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Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanoma
Published in PloS one (29-07-2011)“…Aberrant expression of the progenitor marker Neuron-glia 2 (NG2/CSPG4) or melanoma proteoglycan on cancer cells and angiogenic vasculature is associated with…”
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Combining NK cells and mAb9.2.27 to combat NG2-dependent and anti-inflammatory signals in glioblastoma
Published in Oncoimmunology (01-01-2014)“…Glioblastoma is a deadly brain cancer with limited treatment options. Targeting chondroitin sulfate proteoglycan 4 (CSPG4, best known as NG2) with the…”
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Expression of the progenitor marker NG2/CSPG4 predicts poor survival and resistance to ionising radiation in glioblastoma
Published in Acta neuropathologica (01-10-2011)“…Glioblastoma (GBM) is a highly aggressive brain tumour, where patients respond poorly to radiotherapy and exhibit dismal survival outcomes. The mechanisms of…”
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Thymoma and Autoimmune Encephalitis: Clinical Manifestations and Antibodies
Published in Neurology : neuroimmunology & neuroinflammation (01-09-2021)“…To report the clinical, neuroimaging, and antibody associations in patients with autoimmune encephalitis (AE) and thymoma. A retrospective cohort study of 43…”
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NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody
Published in Annals of clinical and translational neurology (01-11-2017)“…Objective Autoimmune encephalitis is most frequently associated with anti‐NMDAR autoantibodies. Their pathogenic relevance has been suggested by passive…”
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Cytoplasmic Prep1 interacts with 4EHP inhibiting Hoxb4 translation
Published in PloS one (13-04-2009)“…Homeobox genes are essential for embryonic patterning and cell fate determination. They are regulated mostly at the transcriptional level. In particular, Prep1…”
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LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory
Published in Brain (London, England : 1878) (01-11-2018)“…See Debanne and El Far (doi:10.1093/brain/awy271) for a scientific commentary on this article. Anti-LGI1 encephalitis is the most frequent cause of autoimmune…”
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Autoimmune seizures and epilepsy
Published in The Journal of clinical investigation (01-03-2019)“…The rapid expansion in the number of encephalitis disorders associated with autoantibodies against neuronal proteins has led to an incremental increase in use…”
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Filamin A-hinge region 1-EGFP: a novel tool for tracking the cellular functions of filamin A in real-time
Published in PloS one (01-08-2012)“…Filamin A (FLNa) is an actin-crosslinking protein necessary for stabilizing the cell surface, organizing protrusive activity and for promoting efficient…”
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A differential gene expression profile reveals overexpression of RUNX1/AML1 in invasive endometrioid carcinoma
Published in Cancer research (Chicago, Ill.) (15-12-2004)“…Endometrial carcinoma is the most common gynecological malignant disease in industrialized countries. Two clinicopathological types of endometrial carcinoma…”
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Filamin a binds to CCR2B and regulates its internalization
Published in PloS one (17-08-2010)“…The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major…”
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Up-regulation of ERM/ETV5 correlates with the degree of myometrial infiltration in endometrioid endometrial carcinoma
Published in The Journal of pathology (01-12-2005)“…To elucidate alterations in gene expression in endometrioid endometrial carcinoma (EEC), differential gene expression profiling was previously described in…”
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NMDAR Antibodies Alter Dopamine Receptors and Cause Psychotic Behavior in Mice
Published in Annals of neurology (01-09-2020)“…Objective The aim was to demonstrate that antibodies from patients with anti‐N‐methyl‐d‐aspartate receptor (NMDAR) encephalitis alter the levels of dopamine 1…”
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Active Immunization Against NMDA NR1 Subunit as a Model of Autoimmune Encephalitis
Published in Neurology (05-12-2022)Get full text
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