Search Results - "Plakhova, Vera B."
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Role of the Guanidinium Groups in Ligand–Receptor Binding of Arginine-Containing Short Peptides to the Slow Sodium Channel: Quantitative Approach to Drug Design of Peptide Analgesics
Published in International journal of molecular sciences (13-09-2022)“…Several arginine-containing short peptides have been shown by the patch-clamp method to effectively modulate the NaV1.8 channel activation gating system, which…”
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Arginine-Containing Tripeptides as Analgesic Substances: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel
Published in International journal of molecular sciences (26-05-2022)“…Two short arginine-containing tripeptides, H-Arg-Arg-Arg-OH (TP1) and Ac-Arg-Arg-Arg-NH (TP2), have been shown by the patch-clamp method to modulate the Na 1.8…”
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Role of the Rhamnosyl Residue of Ouabain in the Activation of the Na,K-ATPase Signaling Function
Published in Life (Basel, Switzerland) (01-07-2023)“…The signaling or non-pumping Na,K-ATPase function was first observed by us in the nociceptive neuron; Na,K-ATPase transduced the signals from the opioid-like…”
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Short Lysine-Containing Tripeptide as Analgesic Substance: The Possible Mechanism of Ligand-Receptor Binding to the Slow Sodium Channel
Published in Life (Basel, Switzerland) (01-10-2024)“…A possible molecular mechanism of the ligand-receptor binding of Ac-Lys-Lys-Lys-NH (Ac-KKK-NH ) to the Na 1.8 channel that is responsible for nociceptive…”
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Analgesic Effect of the Lysine-Containing Short Peptide Is Due to Modulation of the NaV1.8 Channel Activation Gating System
Published in Life (Basel, Switzerland) (24-08-2023)“…The present work continues our recent series of articles that aim to elucidate the ligand–receptor binding mechanism of short cationic peptides to the NaV1.8…”
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Mechanism of pain relief by low-power infrared irradiation: ATP is an IR-target molecule in nociceptive neurons
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01-01-2012)“…Effects of infrared (IR) radiation generated by a low-power CO2-laser on the membrane of cultured dissociated nociceptive neurons of newborn rat spinal ganglia…”
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New approaches to the design of analgesic medicinal substances
Published in Canadian journal of physiology and pharmacology (01-01-2022)“…A gamma-pyrone derivative, comenic acid, activates the opioid-like receptor-mediated signaling pathway that modulates the Na 1.8 channels in the primary…”
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Molecular mechanisms and signaling by comenic acid in nociceptive neurons influence the pathophysiology of neuropathic pain
Published in Pathophysiology (Amsterdam) (01-09-2019)“…Comenic acid (CA), a specific agonist of opioid-like receptors, effectively and safely relieves neuropathic pain by decreasing the NaV1.8 channel voltage…”
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Modulation of signal-transducing function of neuronal membrane Na+,K+-ATPase by endogenous ouabain and low-power infrared radiation leads to pain relief
Published in Medicinal chemistry (Shp-sariqah, United Arab Emirates) (01-01-2012)“…Effects of infrared (IR) radiation generated by a low-power Co2-laser on sensory neurons of chick embryos were investigated by organotypic culture method…”
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Analgesic Effect of the Lysine-Containing Short Peptide Is Due to Modulation of the Na[sub.V]1.8 Channel Activation Gating System
Published in Life (Basel, Switzerland) (01-08-2023)“…The present work continues our recent series of articles that aim to elucidate the ligand–receptor binding mechanism of short cationic peptides to the…”
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Possible physiological function of endogenous ouabain
Published in Integrativnaâ fiziologiâ (2021)Get full text
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