Search Results - "Place, E."

DNA Sensing in the Innate Immune Response by Briard, Benoit, Place, David E, Kanneganti, Thirumala-Devi

“…The innate immune system recognizes conserved pathogen-associated molecular patterns and produces inflammatory cytokines that direct downstream immune…”
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Cell death-mediated cytokine release and its therapeutic implications by Place, David E, Kanneganti, Thirumala-Devi

“…Targeting apoptosis to treat diseases has seen tremendous success over the past decades. More recently, alternative forms of regulated cell death, including…”
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The microenvironment in breast cancer progression: biology and implications for treatment by Place, Andrew E, Jin Huh, Sung, Polyak, Kornelia

“…Breast cancer comprises a heterogeneous group of malignancies derived from the ductal epithelium. The microenvironment of these cancers is now recognized as a…”
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DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome by Samir, Parimal, Kesavardhana, Sannula, Patmore, Deanna M., Gingras, Sebastien, Malireddi, R. K. Subbarao, Karki, Rajendra, Guy, Clifford S., Briard, Benoit, Place, David E., Bhattacharya, Anannya, Sharma, Bhesh Raj, Nourse, Amanda, King, Sharon V., Pitre, Aaron, Burton, Amanda R., Pelletier, Stephane, Gilbertson, Richard J., Kanneganti, Thirumala-Devi

“…The cellular stress response has a vital role in regulating homeostasis by modulating cell survival and death. Stress granules are cytoplasmic compartments…”
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Identification of the PANoptosome: A Molecular Platform Triggering Pyroptosis, Apoptosis, and Necroptosis (PANoptosis) by Christgen, Shelbi, Zheng, Min, Kesavardhana, Sannula, Karki, Rajendra, Malireddi, R K Subbarao, Banoth, Balaji, Place, David E, Briard, Benoit, Sharma, Bhesh Raj, Tuladhar, Shraddha, Samir, Parimal, Burton, Amanda, Kanneganti, Thirumala-Devi

“…Programmed cell death plays crucial roles in organismal development and host defense. Recent studies have highlighted mechanistic overlaps and extensive,…”
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IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes by Man, Si Ming, Karki, Rajendra, Sasai, Miwa, Place, David E., Kesavardhana, Sannula, Temirov, Jamshid, Frase, Sharon, Zhu, Qifan, Malireddi, R.K. Subbarao, Kuriakose, Teneema, Peters, Jennifer L., Neale, Geoffrey, Brown, Scott A., Yamamoto, Masahiro, Kanneganti, Thirumala-Devi

“…The inflammasome is an intracellular signaling complex, which on recognition of pathogens and physiological aberration, drives activation of caspase-1,…”
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Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins by Place, David E., Malireddi, R. K. Subbarao, Kim, Jieun, Vogel, Peter, Yamamoto, Masahiro, Kanneganti, Thirumala-Devi

“…Chronic inflammation during many diseases is associated with bone loss. While interferons (IFNs) are often inhibitory to osteoclast formation, the complex role…”
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Interferon‐inducible guanylate‐binding proteins at the interface of cell‐autonomous immunity and inflammasome activation by Man, Si Ming, Place, David E., Kuriakose, Teneema, Kanneganti, Thirumala‐Devi

“…Guanylate‐binding proteins (GBPs) are essential components of cell‐autonomous immunity. In response to IFN signaling, GBPs are expressed in the cytoplasm of…”
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Galactosaminogalactan activates the inflammasome to provide host protection by Briard, Benoit, Fontaine, Thierry, Samir, Parimal, Place, David E., Muszkieta, Laetitia, Malireddi, R. K. Subbarao, Karki, Rajendra, Christgen, Shelbi, Bomme, Perrine, Vogel, Peter, Beau, Rémi, Mellado, Emilia, Ibrahim-Granet, Oumaima, Henrissat, Bernard, Kalathur, Ravi C., Robinson, Cam, Latgé, Jean-Paul, Kanneganti, Thirumala-Devi

“…Inflammasomes are important sentinels of innate immune defence that are activated in response to diverse stimuli, including pathogen-associated molecular…”
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Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes by Marusyk, Andriy, Tabassum, Doris P, Janiszewska, Michalina, Place, Andrew E, Trinh, Anne, Rozhok, Andrii I, Pyne, Saumyadipta, Guerriero, Jennifer L, Shu, Shaokun, Ekram, Muhammad, Ishkin, Alexander, Cahill, Daniel P, Nikolsky, Yuri, Chan, Timothy A, Rimawi, Mothaffar F, Hilsenbeck, Susan, Schiff, Rachel, Osborne, Kent C, Letai, Antony, Polyak, Kornelia

“…Using a three-dimensional coculture model, we identified significant subtype-specific changes in gene expression, metabolic, and therapeutic sensitivity…”
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Intravenous pegylated asparaginase versus intramuscular native Escherichia coli l -asparaginase in newly diagnosed childhood acute lymphoblastic leukaemia (DFCI 05-001): a randomised, open-label phase 3 trial by Place, Andrew E, MD, Stevenson, Kristen E, MS, Vrooman, Lynda M, MD, Harris, Marian H, MD, Hunt, Sarah K, MPH, O'Brien, Jane E, BA, Supko, Jeffrey G, PhD, Asselin, Barbara L, MD, Athale, Uma H, MD, Clavell, Luis A, Prof, Cole, Peter D, MD, Kelly, Kara M, Prof, Laverdiere, Caroline, MD, Leclerc, Jean-Marie, MD, Michon, Bruno, MD, Schorin, Marshall A, Prof, Welch, Jennifer J G, MD, Lipshultz, Steven E, Prof, Kutok, Jeffery L, MD, Blonquist, Traci M, MS, Neuberg, Donna S, ScD, Sallan, Stephen E, Prof, Silverman, Lewis B, Dr

“…Summary Background l -asparaginase is a universal component of treatment for childhood acute lymphoblastic leukaemia, and is usually administered…”
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Interferon inducible GBPs restrict Burkholderia thailandensis motility induced cell-cell fusion by Place, David E, Briard, Benoit, Samir, Parimal, Karki, Rajendra, Bhattacharya, Anannya, Guy, Clifford S, Peters, Jennifer L, Frase, Sharon, Vogel, Peter, Neale, Geoffrey, Yamamoto, Masahiro, Kanneganti, Thirumala-Devi

“…Innate immunity responds to pathogens by producing alarm signals and activating pathways that make host cells inhospitable for pathogen replication. The…”
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Hierarchical Cell Death Program Disrupts the Intracellular Niche Required for Burkholderia thailandensis Pathogenesis by Place, David E, Christgen, Shelbi, Tuladhar, Shraddha, Vogel, Peter, Malireddi, R K Subbarao, Kanneganti, Thirumala-Devi

“…infections can result in serious diseases with high mortality, such as melioidosis, and they are difficult to treat with antibiotics. Innate immunity is…”
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Environmental effects on water intake and water intake prediction in growing beef cattle by Ahlberg, Cashley M, Allwardt, Kristi, Broocks, Ashley, Bruno, Kelsey, McPhillips, Levi, Taylor, Alexandra, Krehbiel, Clint R, Calvo-Lorenzo, Michelle S, Richards, Chris J, Place, Sara E, DeSilva, Udaya, VanOverbeke, Deborah L, Mateescu, Raluca G, Kuehn, Larry A, Weaber, Robert L, Bormann, Jennifer M, Rolf, Megan M

“…Water is an essential nutrient, but there are few recent studies that evaluate how much water individual beef cattle consume and how environmental factors…”
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Invited review: Contemporary environmental issues: a review of the dairy industry's role in climate change and air quality and the potential of mitigation through improved production efficiency by Place, S E, Mitloehner, F M

“…Environmental concerns involving the dairy industry are shifting from an exclusive focus on water quality to encompass climate change and air quality issues…”
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Is treatment with pimobendan associated with an increased risk of arrhythmias in dogs with heart disease? by Hillyer, S., Hezzell, M., Place, E.

“…Clinical scenario Pimobendan is a positive inotrope and balanced vasodilator via its actions as a calcium sensitiser and phosphodiesterase III inhibitor,…”
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Future of Clinical Genomics in Pediatric Oncology by Janeway, Katherine A, Place, Andrew E, Kieran, Mark W, Harris, Marian H

“…The somatic genomic alterations in pediatric cancers to some extent overlap with those seen in adult cancers, but the exact distribution throughout the genome…”
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Use of the osmolal gap in diagnosing mixed physiology hyponatremia in a child with B‐cell acute lymphoblastic leukemia by Gabbay, Jonathan M., Place, Andrew E., Ilowite, Maya, Zhu, Jia

“…Key Clinical Message Hyponatremia is common among children undergoing treatment for hematologic malignancies and may be attributed to multiple underlying…”
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Impairment of health-related quality of life for children with acute lymphoblastic leukemia over the first year of therapy: A report from the DFCI ALL Consortium by Welch, Jennifer J G, Flamand, Yael, Stevenson, Kristen E, Neuberg, Donna S, Athale, Uma H, Kelly, Kara M, Laverdiere, Caroline, Michon, Bruno, Place, Andrew E, Sallan, Stephen E, Silverman, Lewis B, Vrooman, Lynda M

“…Children treated for acute lymphoblastic leukemia (ALL) receive prolonged treatment, resulting in toxicities that affect health-related quality of life…”
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The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signaling by LIBY, Karen, HOCK, Thomas, GRIBBLE, Gordon W, HILL-KAPTURCZAK, Nathalie, AGARWAL, Anupam, SPORN, Michael B, YORE, Mark M, SUH, Nanjoo, PLACE, Andrew E, RISINGSONG, Renee, WILLIAMS, Charlotte R, ROYCE, Darlene B, HONDA, Tadashi, HONDA, Yukiko

“…The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO) and its derivative…”
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