Search Results - "Placantonakis, Dimitris"

Cerebrospinal fluid in COVID-19: A systematic review of the literature by Lewis, Ariane, Frontera, Jennifer, Placantonakis, Dimitris G., Lighter, Jennifer, Galetta, Steven, Balcer, Laura, Melmed, Kara R.

“…We sought to review the literature on cerebrospinal fluid (CSF) testing in patients with COVID-19 for evidence of viral neuroinvasion by SARS-CoV-2. We…”
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Sox2 antagonizes the Hippo pathway to maintain stemness in cancer cells by Basu-Roy, Upal, Bayin, N. Sumru, Rattanakorn, Kirk, Han, Eugenia, Placantonakis, Dimitris G., Mansukhani, Alka, Basilico, Claudio

“…The repressive Hippo pathway has a profound tumour suppressive role in cancer by restraining the growth-promoting function of the transcriptional coactivator,…”
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Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen by Depledge, Daniel P., Srinivas, Kalanghad Puthankalam, Sadaoka, Tomohiko, Bready, Devin, Mori, Yasuko, Placantonakis, Dimitris G., Mohr, Ian, Wilson, Angus C.

“…Characterizing complex viral transcriptomes by conventional RNA sequencing approaches is complicated by high gene density, overlapping reading frames, and…”
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Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics by Golub, Danielle, Iyengar, Nishanth, Dogra, Siddhant, Wong, Taylor, Bready, Devin, Tang, Karen, Modrek, Aram S, Placantonakis, Dimitris G

“…The identification of heterozygous neomorphic isocitrate dehydrogenase (IDH) mutations across multiple cancer types including both solid and hematologic…”
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Activation of the adhesion G protein–coupled receptor GPR133 by antibodies targeting its N-terminus by Stephan, Gabriele, Frenster, Joshua D., Liebscher, Ines, Placantonakis, Dimitris G.

“…We recently demonstrated that GPR133 (ADGRD1), an adhesion G protein–coupled receptor involved in raising cytosolic cAMP levels, is necessary for growth of…”
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Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase-mutant Glioma by Spino, Marissa, Kurz, Sylvia C, Chiriboga, Luis, Serrano, Jonathan, Zeck, Briana, Sen, Namita, Patel, Seema, Shen, Guomiao, Vasudevaraja, Varshini, Tsirigos, Aristotelis, Suryadevara, Carter M, Frenster, Joshua D, Tateishi, Kensuke, Wakimoto, Hiroaki, Jain, Rajan, Riina, Howard A, Nicolaides, Theodore P, Sulman, Erik P, Cahill, Daniel P, Golfinos, John G, Isse, Kumiko, Saunders, Laura R, Zagzag, David, Placantonakis, Dimitris G, Snuderl, Matija, Chi, Andrew S

“…Isocitrate dehydrogenase ( )-mutant glioma is a distinct glioma molecular subtype for which no effective molecularly directed therapy exists. Low-grade…”
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Dissecting the immunosuppressive tumor microenvironments in Glioblastoma-on-a-Chip for optimized PD-1 immunotherapy by Cui, Xin, Ma, Chao, Vasudevaraja, Varshini, Serrano, Jonathan, Tong, Jie, Peng, Yansong, Delorenzo, Michael, Shen, Guomiao, Frenster, Joshua, Morales, Renee-Tyler Tan, Qian, Weiyi, Tsirigos, Aristotelis, Chi, Andrew S, Jain, Rajan, Kurz, Sylvia C, Sulman, Erik P, Placantonakis, Dimitris G, Snuderl, Matija, Chen, Weiqiang

“…Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity…”
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Cerebrospinal fluid findings in patients with seizure in the setting of COVID-19: A review of the literature by Carroll, Elizabeth, Melmed, Kara R., Frontera, Jennifer, Placantonakis, Dimitris G., Galetta, Steven, Balcer, Laura, Lewis, Ariane

“…•We identified 69 patients with COVID-19 who had a seizure and CSF obtained.•CSF SARS-CoV-2 was positive for 6/45 (13%) patients.•Of 11 patients who had CSF…”
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Molecular Pathogenesis of Low-Grade Glioma by Bready, Devin, BS, Placantonakis, Dimitris G., MD, PhD

“…Advances in genome sequencing have elucidated the genetics of low-grade glioma. Available evidence indicates a neomorphic mutation in isocitrate dehydrogenase…”
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Lactate reprograms glioblastoma immunity through CBX3-regulated histone lactylation by Wang, Shuai, Huang, Tengfei, Wu, Qiulian, Yuan, Huairui, Wu, Xujia, Yuan, Fanen, Duan, Tingting, Taori, Suchet, Zhao, Yingming, Snyder, Nathaniel W, Placantonakis, Dimitris G, Rich, Jeremy N

“…Glioblastoma (GBM), an aggressive brain malignancy with a cellular hierarchy dominated by GBM stem cells (GSCs), evades antitumor immunity through mechanisms…”
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Traumatic brain injury: Mechanisms, manifestations, and visual sequelae by Rauchman, Steve H, Zubair, Aarij, Jacob, Benna, Rauchman, Danielle, Pinkhasov, Aaron, Placantonakis, Dimitris G, Reiss, Allison B

“…Traumatic brain injury (TBI) results when external physical forces impact the head with sufficient intensity to cause damage to the brain. TBI can be mild,…”
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Editorial: Manifestations of mild-to-moderate traumatic brain injury by Rauchman, Steven H., Placantonakis, Dimitris G., Reiss, Allison B.

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Orthotopic Patient-Derived Glioblastoma Xenografts in Mice by Xu, Zhongye, Kader, Michael, Sen, Rajeev, Placantonakis, Dimitris G

“…Patient-derived xenografts (PDX) provide in vivo glioblastoma (GBM) models that recapitulate actual tumors. Orthotopic tumor xenografts within the mouse brain…”
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Functional impact of intramolecular cleavage and dissociation of adhesion G protein–coupled receptor GPR133 (ADGRD1) on canonical signaling by Frenster, Joshua D., Stephan, Gabriele, Ravn-Boess, Niklas, Bready, Devin, Wilcox, Jordan, Kieslich, Bjoern, Wilde, Caroline, Sträter, Norbert, Wiggin, Giselle R., Liebscher, Ines, Schöneberg, Torsten, Placantonakis, Dimitris G.

“…GPR133 (ADGRD1), an adhesion G protein–coupled receptor (GPCR) whose canonical signaling activates GαS-mediated generation of cytosolic cAMP, has been shown to…”
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Cerebrospinal fluid from COVID-19 patients with olfactory/gustatory dysfunction: A review by Lewis, Ariane, Frontera, Jennifer, Placantonakis, Dimitris G., Galetta, Steven, Balcer, Laura, Melmed, Kara R.

“…We reviewed the literature on cerebrospinal fluid (CSF) testing in patients with altered olfactory/gustatory function due to COVID-19 for evidence of viral…”
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Performance of orientation distribution function‐fingerprinting with a biophysical multicompartment diffusion model by Filipiak, Patryk, Shepherd, Timothy, Lin, Ying‐Chia, Placantonakis, Dimitris G., Boada, Fernando E., Baete, Steven H.

“…Purpose Orientation Distribution Function (ODF) peak finding methods typically fail to reconstruct fibers crossing at shallow angles below 40°, leading to…”
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T2-FLAIR Mismatch Sign Predicts DNA Methylation Subclass and CDKN2A/B Status in IDH-Mutant Astrocytomas by Lee, Matthew D, Jain, Rajan, Galbraith, Kristyn, Chen, Anna, Lieberman, Evan, Patel, Sohil H, Placantonakis, Dimitris G, Zagzag, David, Barbaro, Marissa, Guillermo Prieto Eibl, Maria Del Pilar, Golfinos, John G, Orringer, Daniel A, Snuderl, Matija

“…DNA methylation profiling stratifies isocitrate dehydrogenase (IDH)-mutant astrocytomas into methylation low- and high-grade groups. We investigated the…”
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Volumetric growth rates of untreated cavernous sinus meningiomas by Benjamin, Carolina Gesteira, Schnurman, Zane, Ashayeri, Kimberly, Kazi, Eman, Mullen, Reed, Gurewitz, Jason, Golfinos, John G, Sen, Chandranath, Placantonakis, Dimitris G, Pacione, Donato, Kondziolka, Douglas

“…Meningiomas that arise primarily within the cavernous sinus are often believed to be more indolent in their growth pattern. Despite this perceived growth…”
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In vitro evidence for glioblastoma cell death in temperatures found in the penumbra of laser-ablated tumors by Frenster, Joshua D., Desai, Shivang, Placantonakis, Dimitris G.

“…The concept of thermal therapy toward the treatment of brain tumors has gained traction in recent years. Traditionally, thermal therapy has been subdivided…”
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Laser interstitial thermal therapy for new and recurrent meningioma: a prospective and retrospective case series by Chiang, Veronica L, Pugazenthi, Sangami, Leidig, William A, Rodriguez, Analiz, Prabhu, Sujit, Haskell-Mendoza, Aden P, Fecci, Peter E, Placantonakis, Dimitris G, Abram, Steven R, Lega, Bradley, Kim, Albert H

“…Meningiomas are the most common primary brain tumors in adults and a subset are aggressive lesions resistant to standard therapies. Laser interstitial thermal…”
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