Search Results - "Pizza, Grazia"

Transcription-induced formation of extrachromosomal DNA during yeast ageing by Hull, Ryan M, King, Michelle, Pizza, Grazia, Krueger, Felix, Vergara, Xabier, Houseley, Jonathan

“…Extrachromosomal circular DNA (eccDNA) facilitates adaptive evolution by allowing rapid and extensive gene copy number variation and is implicated in the…”
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Identification of miR‐31‐5p, miR‐141‐3p, miR‐200c‐3p, and GLT1 as human liver aging markers sensitive to donor–recipient age‐mismatch in transplants by Capri, Miriam, Olivieri, Fabiola, Lanzarini, Catia, Remondini, Daniel, Borelli, Vincenzo, Lazzarini, Raffaella, Graciotti, Laura, Albertini, Maria Cristina, Bellavista, Elena, Santoro, Aurelia, Biondi, Fiammetta, Tagliafico, Enrico, Tenedini, Elena, Morsiani, Cristina, Pizza, Grazia, Vasuri, Francesco, D'Errico, Antonietta, Dazzi, Alessandro, Pellegrini, Sara, Magenta, Alessandra, D'Agostino, Marco, Capogrossi, Maurizio C., Cescon, Matteo, Rippo, Maria Rita, Procopio, Antonio Domenico, Franceschi, Claudio, Grazi, Gian Luca

“…Summary To understand why livers from aged donors are successfully used for transplants, we looked for markers of liver aging in 71 biopsies from donors aged…”
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Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis by Mousavy Gharavy, S. Neda, Owen, Bryn M., Millership, Steven J., Chabosseau, Pauline, Pizza, Grazia, Martinez-Sanchez, Aida, Tasoez, Emirhan, Georgiadou, Eleni, Hu, Ming, Fine, Nicholas H. F., Jacobson, David A., Dickerson, Matthew T., Idevall-Hagren, Olof, Montoya, Alex, Kramer, Holger, Mehta, Zenobia, Withers, Dominic J., Ninov, Nikolay, Gadue, Paul J., Cardenas-Diaz, Fabian L., Cruciani-Guglielmacci, Céline, Magnan, Christophe, Ibberson, Mark, Leclerc, Isabelle, Voz, Marianne, Rutter, Guy A.

“…Aims/hypothesis Variants close to the VPS13C / C2CD4A/C2CD4B locus are associated with altered risk of type 2 diabetes in genome-wide association studies…”
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Cell‐free DNA as a biomarker of aging by Teo, Yee Voan, Capri, Miriam, Morsiani, Cristina, Pizza, Grazia, Faria, Ana Maria Caetano, Franceschi, Claudio, Neretti, Nicola

“…Cell‐free DNA (cfDNA) is present in the circulating plasma and other body fluids and is known to originate mainly from apoptotic cells. Here, we provide the…”
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Liver kinase B1 (LKB1) regulates the epigenetic landscape of mouse pancreatic beta cells by Haberman, Nejc, Cheung, Rebecca, Pizza, Grazia, Cvetesic, Nevena, Nagy, Dorka, Maude, Hannah, Blazquez, Lorea, Lenhard, Boris, Cebola, Inês, Rutter, Guy A., Martinez‐Sanchez, Aida

“…Liver kinase B1 (LKB1/STK11) is an important regulator of pancreatic β‐cell identity and function. Elimination of Lkb1 from the β‐cell results in improved…”
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Aging yeast gain a competitive advantage on non‐optimal carbon sources by Frenk, Stephen, Pizza, Grazia, Walker, Rachael V., Houseley, Jonathan

“…Summary Animals, plants and fungi undergo an aging process with remarkable physiological and molecular similarities, suggesting that aging has long been a fact…”
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Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function by Cheung, Rebecca, Pizza, Grazia, Chabosseau, Pauline, Rolando, Delphine, Tomas, Alejandra, Burgoyne, Thomas, Wu, Zhiyi, Salowka, Anna, Thapa, Anusha, Macklin, Annabel, Cao, Yufei, Nguyen-Tu, Marie-Sophie, Dickerson, Matthew T, Jacobson, David A, Marchetti, Piero, Shapiro, James, Piemonti, Lorenzo, de Koning, Eelco, Leclerc, Isabelle, Bouzakri, Karim, Sakamoto, Kei, Smith, David M, Rutter, Guy A, Martinez-Sanchez, Aida

“…Impaired pancreatic β-cell function and insulin secretion are hallmarks of type 2 diabetes. miRNAs are short, noncoding RNAs that silence gene expression vital…”
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Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement by Kangas, Reeta, Morsiani, Cristina, Pizza, Grazia, Lanzarini, Catia, Aukee, Pauliina, Kaprio, Jaakko, Sipilä, Sarianna, Franceschi, Claudio, Kovanen, Vuokko, Laakkonen, Eija K, Capri, Miriam

“…Tissue-specific effects of 17β-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat…”
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2183-P: miR-125b Is Regulated by Glucose via AMPK and Impairs ß-Cell Function by CHEUNG, REBECCA, PIZZA, GRAZIA, ROLANDO, DELPHINE M., CHABOSSEAU, PAULINE L., NGUYEN-TU, MARIE-SOPHIE, LECLERC, ISABELLE, RUTTER, GUY A., MARTINEZ-SANCHEZ, AIDA

“…miRNAs are tiny RNAs that repress gene expression post-transcriptionally, necessary for normal endocrine function. AMPK is essential for glucose homeostasis…”
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2183-P: miR-125b Is Regulated by Glucose via AMPK and Impairs β-Cell Function by Cheung, Rebecca, Pizza, Grazia, Rolando, Delphine M, Chabosseau, Pauline L, Nguyen-Tu, Marie-Sophie, Leclerc, Isabelle, Rutter, Guy A, Martinez-Sanchez, Aida

“…miRNAs are tiny RNAs that repress gene expression post-transcriptionally, necessary for normal endocrine function. AMPK is essential for glucose homeostasis…”
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Discussing the role of circular RNA in the pathogenesis of non-alcoholic fatty liver disease and its complications by Cheung, Rebecca, Pizza, Grazia, Chabosseau, Pauline, Rolando, Delphine, Tomas, Alejandra, Burgoyne, Thomas, Wu, Zhiyi, Salowka, Anna, Thapa, Anusha, Macklin, Annabel, Cao, Yufei, Nguyen-Tu, Marie-Sophie, Dickerson, Matthew, Jacobson, David, Marchetti, Piero, Shapiro, James, Piemonti, Lorenzo, de Koning, Eelco, Leclerc, Isabelle, Bouzakri, Karim, Sakamoto, Kei, Smith, David, Rutter, Guy, Martinez-Sanchez, Aida

“…Circular RNAs (circRNAs) are class of non-coding RNA, which are characterized by a covalently closed loop structure. Functionally they can act on cellular…”
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Mucosal immunogenicity of genetically detoxified derivatives of heat labile toxin from Escherichia coli by Douce, Gill, Giulianit, Marzia Monica, Giannelli, Valentina, Pizza, Maria Grazia, Rappuoli, Rino, Dougan, Gordon

“…Using a fixed dose of antigen, the immune response to detoxified mutants of LT—WT following intranasal (i.n.), subcutaneous (s.c.) and oral (i.g.) immunisation…”
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The Arg7Lys Mutant of Heat-Labile Enterotoxin Exhibits Great Flexibility of Active Site Loop 47-56 of the A Subunit by van den Akker, Focco, Merritt, Ethan A, Pizza, MariaGrazia, Domenighini, Mario, Rappuoli, Rino, Hol, Wim G. J

“…The heat-labile enterotoxin from Escherichia coli (LT) is a member of the cholera toxin family. These and other members of the larger class of AB5 bacterial…”
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