Search Results - "Pizcueta, Pilar"

A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma by Puyol, Marta, Martín, Alberto, Dubus, Pierre, Mulero, Francisca, Pizcueta, Pilar, Khan, Gulfaraz, Guerra, Carmen, Santamaría, David, Barbacid, Mariano

“…We have unveiled a synthetic lethal interaction between K- Ras oncogenes and Cdk4 in a mouse tumor model that closely recapitulates human non-small cell lung…”
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Development of PPARγ Agonists for the Treatment of Neuroinflammatory and Neurodegenerative Diseases: Leriglitazone as a Promising Candidate by Pizcueta, Pilar, Vergara, Cristina, Emanuele, Marco, Vilalta, Anna, Rodríguez-Pascau, Laura, Martinell, Marc

“…Increasing evidence suggests that the peroxisome proliferator-activated receptor γ (PPARγ), a member of the nuclear receptor superfamily, plays an important…”
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PPAR gamma agonist leriglitazone improves frataxin-loss impairments in cellular and animal models of Friedreich Ataxia by Rodríguez-Pascau, Laura, Britti, Elena, Calap-Quintana, Pablo, Dong, Yi Na, Vergara, Cristina, Delaspre, Fabien, Medina-Carbonero, Marta, Tamarit, Jordi, Pallardó, Federico V., Gonzalez-Cabo, Pilar, Ros, Joaquim, Lynch, David R., Martinell, Marc, Pizcueta, Pilar

“…Friedreich ataxia (FRDA), the most common autosomal recessive ataxia, is characterized by degeneration of the large sensory neurons and spinocerebellar tracts,…”
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Cannabidiol ameliorates mitochondrial disease via PPARγ activation in preclinical models by Puighermanal, Emma, Luna-Sánchez, Marta, Gella, Alejandro, van der Walt, Gunter, Urpi, Andrea, Royo, María, Tena-Morraja, Paula, Appiah, Isabella, de Donato, Maria Helena, Menardy, Fabien, Bianchi, Patrizia, Esteve-Codina, Anna, Rodríguez-Pascau, Laura, Vergara, Cristina, Gómez-Pallarès, Mercè, Marsicano, Giovanni, Bellocchio, Luigi, Martinell, Marc, Sanz, Elisenda, Jurado, Sandra, Soriano, Francesc Xavier, Pizcueta, Pilar, Quintana, Albert

“…Mutations in mitochondrial energy-producing genes lead to a heterogeneous group of untreatable disorders known as primary mitochondrial diseases (MD). Leigh…”
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Mitochondrial modulation with leriglitazone as a potential treatment for Rett syndrome by Musokhranova, Uliana, Grau, Cristina, Vergara, Cristina, Rodríguez-Pascau, Laura, Xiol, Clara, Castells, Alba A., Alcántara, Soledad, Rodríguez-Pombo, Pilar, Pizcueta, Pilar, Martinell, Marc, García-Cazorla, Angels, Oyarzábal, Alfonso

“…Abstract Background Rett syndrome is a neuropediatric disease occurring due to mutations in MECP2 and characterized by a regression in the neuronal development…”
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Clinical pharmacokinetics of leriglitazone and a translational approach using PBPK modeling to guide the selection of the starting dose in children by Traver, Estefania, Rodríguez‐Pascau, Laura, Meya, Uwe, Pina, Guillem, Pascual, Silvia, Poli, Sonia, Eckland, David, Wetering, Jeroen, Ke, Alice, Lindauer, Andreas, Martinell, Marc, Pizcueta, Pilar

“…Leriglitazone is a unique peroxisome proliferator‐activated receptor‐gamma (PPARγ) agonist that crosses the blood–brain barrier in humans and clinical trials…”
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PPAR Gamma Agonist Leriglitazone Recovers Alterations Due to Pank2-Deficiency in hiPS-Derived Astrocytes by Santambrogio, Paolo, Cozzi, Anna, Di Meo, Ivano, Cavestro, Chiara, Vergara, Cristina, Rodríguez-Pascau, Laura, Martinell, Marc, Pizcueta, Pilar, Tiranti, Valeria, Levi, Sonia

“…The novel brain-penetrant peroxisome proliferator-activated receptor gamma agonist leriglitazone, previously validated for other rare neurodegenerative…”
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Distinct synovial immunopathology in Behçet disease and psoriatic arthritis by Cañete, Juan D, Celis, Raquel, Noordenbos, Troy, Moll, Conchita, Gómez-Puerta, Jose A, Pizcueta, Pilar, Palacin, Antonio, Tak, Paul P, Sanmartí, Raimon, Baeten, Dominique

“…The aim of the study was to investigate synovial immunopathology differences between early Behçet disease (BD) and psoriatic arthritis (PsA). Needle…”
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Identification and Functional Characterization of the Hepatic Stellate Cell CD38 Cell Surface Molecule by March, Sandra, Graupera, Mariona, Rosa Sarrias, María, Lozano, Francisco, Pizcueta, Pilar, Bosch, Jaume, Engel, Pablo

“…The activation of hepatic stellate cells (HSCs) is a critical event in hepatic fibrosis, because these cells are the main producers of extracellular matrix…”
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Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition by Pizcueta, P, Piqué, J M, Fernández, M, Bosch, J, Rodés, J, Whittle, B J, Moncada, S

“…The effects of NG-monomethyl-L-arginine (L-NMMA), an inhibitor of nitric oxide (NO) biosynthesis on the splanchnic and systemic circulation, were investigated…”
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Platelets activated by transient coronary occlusion exacerbate ischemia-reperfusion injury in rat hearts by Mirabet, Maribel, Garcia-Dorado, David, Inserte, Javier, Barrabés, José A, Lidón, Rosa-M, Soriano, Bernat, Azevedo, Marta, Padilla, Ferran, Agulló, Luis, Ruiz-Meana, Marisol, Massaguer, Anna, Pizcueta, Pilar, Soler-Soler, Jordi

“…Platelets (Plt) accumulate in reperfused myocardium but their effect on myocardial necrosis has not been established. We tested the hypothesis that the effect…”
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Concanavalin-A-induced liver injury is severely impaired in mice deficient in P-selectin by Massaguer, Anna, Perez‐del‐Pulgar, Sofía, Engel, Pablo, Serratosa, Joan, Bosch, Jaime, Pizcueta, Pilar

“…P‐selectin (CD62P) is an adhesion molecule that mediates the initial attachment of leukocytes to activated platelets and endothelial cells in damaged tissues…”
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Enhanced monocyte activation and hepatotoxicity in response to endotoxin in portal hypertension by Pulgar, Sofía Pérez del, Pizcueta, Pilar, Engel, Pablo, Bosch, Jaume

“…Background/Aims: Septic shock is a systemic response to infection, and it causes a high mortality rate in cirrhotic patients. The mechanisms responsible for…”
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The brain penetrant PPARγ agonist leriglitazone restores multiple altered pathways in models of X-linked adrenoleukodystrophy by Rodríguez-Pascau, Laura, Vilalta, Anna, Cerrada, Marc, Traver, Estefania, Forss-Petter, Sonja, Weinhofer, Isabelle, Bauer, Jan, Kemp, Stephan, Pina, Guillem, Pascual, Sílvia, Meya, Uwe, Musolino, Patricia L, Berger, Johannes, Martinell, Marc, Pizcueta, Pilar

“…X-linked adrenoleukodystrophy (X-ALD), a potentially fatal neurometabolic disorder with no effective pharmacological treatment, is characterized by clinical…”
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MIN102 (Leriglitazone), a Brain Penetrant PPAR Gamma Agonist for the Treatment of Friedreich’s Ataxia (4147) by Poli, Sonia, Rodríguez-Pascau, Laura, Britti, Elena, Ros, Joaquim, González-Cab, Pilar, Lynch, David, Martinell, Marc, Pizcueta, Pilar

“…Abstract only…”
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A Phase 1 Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effects on Biomarkers of MIN-102 (Leriglitazone) (4149) by Meya, Uwe, Pina, Guillem, Pascual, Silvia, Cerrada-Gimenez, Marc, Pizcueta, Pilar, Martinell, Marc, Eckland, David, Wetering de Rooij, Jeroen v.d.

“…Abstract only…”
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Safety and efficacy of leriglitazone for preventing disease progression in men with adrenomyeloneuropathy (ADVANCE): a randomised, double-blind, multi-centre, placebo-controlled phase 2–3 trial by Köhler, Wolfgang, Engelen, Marc, Eichler, Florian, Lachmann, Robin, Fatemi, Ali, Sampson, Jacinda, Salsano, Ettore, Gamez, Josep, Molnar, Maria Judit, Pascual, Sílvia, Rovira, Maria, Vilà, Anna, Pina, Guillem, Martín-Ugarte, Itziar, Mantilla, Adriana, Pizcueta, Pilar, Rodríguez-Pascau, Laura, Traver, Estefania, Vilalta, Anna, Pascual, María, Martinell, Marc, Meya, Uwe, Mochel, Fanny, Mc Govern, Eavan, Yazbeck, Elise, Barbier, Magali, Luton, Marie-Pierre, Pousset, Françoise, Hogrel, Jean-Yves, Adanyeguh, Isaac, Then Bergh, Florian, Bergner, Caroline, Unterlauft, Astrid, Roicke, Hannes, Hoffmann, Karl-Titus, Scherlach, Cordula, Kalb, Andrea, Meilick, Bianca, Reuschel, Mandy, Fenu, Silvia, Mauro, Elena, Murphy, Elaine, Krishna, Gauri, Beyene, Tiggy, Sierra, Alba, Quiñoa, Sara, Belen Canovas, Anna, Grosz, Zoltan, Györgyi, Báthori, van de Stadt, S.I., Huffnagel, I.C., van Ballegoij, W.J.C., Voermans, M.M.C., Seyedsadjadi, Reza, Corre, Camille, Godbole, Neha, Grant, Natalie Rose, Brito Pires, Claudia Maria, Trovato, Melissa, Yeh, Nancy, Goodman, Jordan, Keller, Jennifer, Joseph, Chris, Van Haren, Keith, Sakamuri, Sarada, Duong, Tina, Perrone, Lila, Tran, Stephanie, Dunaway Young, Sally, Hashmi, Syed

“…Adult patients with adrenoleukodystrophy have a poor prognosis owing to development of adrenomyeloneuropathy. Additionally, a large proportion of patients with…”
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MIN-102 (leriglitazone), a Brain Penetrant PPAR gamma Agonist, Decreases Neuroinflammation and Neurodegeneration and Promotes Re-Myelination in Preclinical Models of X-linked Adrenoleukodystrophy (X-ALD) (759) by Poli, Sonia, Vilalta, Anna, Rodríguez-Pascau, Laura, Cerrada-Gimenez, Marc, Berger, Johannes, Forss-Petter, Sonja, Weinhofer, Isabelle, Musolino, Patricia, Martinell, Marc, Pizcueta, Pilar

“…Abstract only…”
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Hemodynamic effects of blood volume restitution following a hemorrhage in rats with portal hypertension due to cirrhosis of the liver: influence of the extent of portal-systemic shunting by Kravetz, D, Bosch, J, Arderiu, M, Pilar Pizcueta, M, Rodés, J

“…The present study investigated whether, in rats with portal hypertension due to cirrhosis of the liver induced by carbon tetrachloride, blood volume…”
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Hemodynamic effects of glucagon in portal hypertension by Silva, G, Navasa, M, Bosch, J, Chesta, J, Pilar Pizcueta, M, Casamitjana, R, Rivera, F, Rodés, J

“…It has been suggested that glucagon contributes to the pathogenesis of portal hypertension by increasing portal blood flow. This study examined this issue by…”
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