Search Results - "Pizarro, T"

The Treg/Th17 Axis: A Dynamic Balance Regulated by the Gut Microbiome by Omenetti, Sara, Pizarro, Theresa T

“…T-helper 17 (Th17) and T-regulatory (Treg) cells are frequently found at barrier surfaces, particularly within the intestinal mucosa, where they function to…”
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Novel Pharmacological Therapy in Inflammatory Bowel Diseases: Beyond Anti-Tumor Necrosis Factor by Pagnini, Cristiano, Pizarro, Theresa T, Cominelli, Fabio

“…Inflammatory bowel diseases (IBDs) are chronic conditions of the gastrointestinal tract in which dysregulated immune responses cause persistent inflammation of…”
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Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis by Liao, Yun, Zhao, Junjie, Bulek, Katarzyna, Tang, Fangqiang, Chen, Xing, Cai, Gang, Jia, Shang, Fox, Paul L., Huang, Emina, Pizarro, Theresa T., Kalady, Matthew F., Jackson, Mark W., Bao, Shideng, Sen, Ganes C., Stark, George R., Chang, Christopher J., Li, Xiaoxia

“…Copper levels are known to be elevated in inflamed and malignant tissues. But the mechanism underlying this selective enrichment has been elusive. In this…”
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The Artificial Sweetener Splenda Promotes Gut Proteobacteria, Dysbiosis, and Myeloperoxidase Reactivity in Crohn's Disease-Like Ileitis by Rodriguez-Palacios, Alexander, Harding, Andrew, Menghini, Paola, Himmelman, Catherine, Retuerto, Mauricio, Nickerson, Kourtney P, Lam, Minh, Croniger, Colleen M, McLean, Mairi H, Durum, Scott K, Pizarro, Theresa T, Ghannoum, Mahmoud A, Ilic, Sanja, McDonald, Christine, Cominelli, Fabio

“…Abstract Background Epidemiological studies indicate that the use of artificial sweeteners doubles the risk for Crohn's disease (CD). Herein, we experimentally…”
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Probiotics promote gut health through stimulation of epithelial innate immunity by Pagnini, Cristiano, Saeed, Rubina, Bamias, Giorgos, Arseneau, Kristen O, Pizarro, Theresa T, Cominelli, Fabio

“…Probiotic formulations are widely available and have a variety of proposed beneficial effects, including promotion of gut health. The mechanisms of action of…”
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Central role of the gut epithelial barrier in the pathogenesis of chronic intestinal inflammation: lessons learned from animal models and human genetics by Pastorelli, Luca, De Salvo, Carlo, Mercado, Joseph R, Vecchi, Maurizio, Pizarro, Theresa T

“…The gut mucosa is constantly challenged by a bombardment of foreign antigens and environmental microorganisms. As such, the precise regulation of the…”
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IL-33 promotes recovery from acute colitis by inducing miR-320 to stimulate epithelial restitution and repair by Lopetuso, Loris R., De Salvo, Carlo, Pastorelli, Luca, Rana, Nitish, Senkfor, Henry N., Petito, Valentina, Di Martino, Luca, Scaldaferri, Franco, Gasbarrini, Antonio, Cominelli, Fabio, Abbott, Derek W., Goodman, Wendy A., Pizarro, Theresa T.

“…Defective and/or delayed wound healing has been implicated in the pathogenesis of several chronic inflammatory disorders, including inflammatory bowel disease…”
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Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism by Corridoni, Daniele, Pastorelli, Luca, Mattioli, Benedetta, Locovei, Silviu, Ishikawa, Dai, Arseneau, Kristen O, Chieppa, Marcello, Cominelli, Fabio, Pizarro, Theresa T

“…We previously showed that the probiotic mixture, VSL#3, prevents the onset of ileitis in SAMP/YitFc (SAMP) mice, and this effect was associated with…”
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Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis by Pastorelli, Luca, Garg, Rekha R, Hoang, Sharon B, Spina, Luisa, Mattioli, Benedetta, Scarpa, Melania, Fiocchi, Claudio, Vecchi, Maurizio, Pizarro, Theresa T

“…IL-33 is a novel member of the IL-1 family and ligand for the IL-1 receptor-related protein, ST2. Recent evidence suggests that the IL-33/ST2 axis plays a…”
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IL-33 activates tumor stroma to promote intestinal polyposis by Maywald, Rebecca L., Doerner, Stephanie K., Pastorelli, Luca, De Salvo, Carlo, Benton, Susan M., Dawson, Emily P., Lanza, Denise G., Berger, Nathan A., Markowitz, Sanford D., Lenz, Heinz-Josef, Nadeau, Joseph H., Pizarro, Theresa T., Heaney, Jason D.

“…Tumor epithelial cells develop within a microenvironment consisting of extracellular matrix, growth factors, and cytokines produced by nonepithelial stromal…”
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Associations between genetic polymorphisms in IL-33, IL1R1 and risk for inflammatory bowel disease by Latiano, Anna, Palmieri, Orazio, Pastorelli, Luca, Vecchi, Maurizio, Pizarro, Theresa T, Bossa, Fabrizio, Merla, Giuseppe, Augello, Bartolomeo, Latiano, Tiziana, Corritore, Giuseppe, Settesoldi, Alessia, Valvano, Maria Rosa, D'Incà, Renata, Stronati, Laura, Annese, Vito, Andriulli, Angelo

“…Recent evidence suggests that the IL-33/IL1RL1 axis plays a critical role in several autoimmune and inflammatory disorders; however, its mechanistic role in…”
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Novel Insights Into the Interactions Between the Gut Microbiome, Inflammasomes, and Gasdermins During Colorectal Cancer by Privitera, Giuseppe, Rana, Nitish, Scaldaferri, Franco, Armuzzi, Alessandro, Pizarro, Theresa T

“…Colorectal cancer (CRC) is one of the most prevalent and deadly forms of cancer in Western countries. Inflammation is a well-known driver of colonic…”
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In Vivo Inhibition of RIPK2 Kinase Alleviates Inflammatory Disease by Tigno-Aranjuez, Justine T., Benderitter, Pascal, Rombouts, Frederik, Deroose, Frederik, Bai, XiaoDong, Mattioli, Benedetta, Cominelli, Fabio, Pizarro, Theresa T., Hoflack, Jan, Abbott, Derek W.

“…The RIPK2 kinase transduces signaling downstream of the intracellular peptidoglycan sensors NOD1 and NOD2 to promote a productive inflammatory response…”
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Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease by Lopetuso, Loris R, Chowdhry, Saleem, Pizarro, Theresa T

“…In addition to their well-established role(s) in the pathogenesis of gastrointestinal (GI)-related inflammatory disorders, including inflammatory bowel disease…”
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Cytokine-Mediated Regulation of Innate Lymphoid Cell Plasticity in Gut Mucosal Immunity by De Salvo, Carlo, Buela, Kristine-Ann, Pizarro, Theresa T

“…Mucosal barriers are active sites that encounter a bombardment of antigenic stimuli derived from both the commensal flora and a variety of pathogens, as well…”
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Association between metabolic syndrome components and gingival bleeding is women-specific: a nested cross-sectional study by Pietropaoli, Davide, Altamura, Serena, Ortu, Eleonora, Guerrini, Luca, Pizarro, Theresa T, Ferri, Claudio, Del Pinto, Rita

“…Metabolic syndrome (MetS) is a cluster of atherosclerotic risk factors that increases cardiovascular risk. MetS has been associated with periodontitis, but the…”
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Expression, Localization, and Functional Activity of TL1A, a Novel Th1-Polarizing Cytokine in Inflammatory Bowel Disease by Bamias, Giorgos, Martin, Charles, III, Marini, Marco, Hoang, Sharon, Mishina, Margarita, Ross, William G, Sachedina, Muhammadreza A, Friel, Charles M, Mize, James, Bickston, Stephen J, Pizarro, Theresa T, Wei, Ping, Cominelli, Fabio

“…TL1A is a novel TNF-like factor that acts as a costimulator of IFN-gamma secretion through binding to the death domain-containing receptor, DR3. The aim of…”
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Live or let die: Translational insights and clinical perspectives of gasdermin B‐dependent intestinal epithelial cell fate by Privitera, Giuseppe, Pizarro, Theresa T.

“…[...]the activation of particular GSDMB-dependent functions necessitates specific signals or events, often in cooperation with other gut mucosal cells and/or…”
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Stereomicroscopic 3D-pattern profiling of murine and human intestinal inflammation reveals unique structural phenotypes by Rodriguez-Palacios, Alex, Kodani, Tomohiro, Kaydo, Lindsey, Pietropaoli, Davide, Corridoni, Daniele, Howell, Scott, Katz, Jeffry, Xin, Wei, Pizarro, Theresa T., Cominelli, Fabio

“…Histology is fundamental to assess two-dimensional intestinal inflammation; however, inflammatory bowel diseases (IBDs) are often indistinguishable…”
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Editorial: Cytokines and Intestinal Mucosal Immunity by Pizarro, Theresa T, Dinarello, Charles A, Cominelli, Fabio

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