Search Results - "Pizard, A."

Preventive and chronic mineralocorticoid receptor antagonism is highly beneficial in obese SHHF rats by Youcef, G, Olivier, A, Nicot, N, Muller, A, Deng, C, Labat, C, Fay, R, Rodriguez‐Guéant, R‐M, Leroy, C, Jaisser, F, Zannad, F, Lacolley, P, Vallar, L, Pizard, A

“…Background and Purpose Mineralocorticoid receptor (MR) activation contributes to heart failure (HF) progression. Its overactivity in obesity is thought to…”
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Disseminated Arterial Calcification and Enhanced Myogenic Response Are Associated With Abcc6 Deficiency in a Mouse Model of Pseudoxanthoma Elasticum by Kauffenstein, Gilles, Pizard, A, Le Corre, Y, Vessières, E, Grimaud, L, Toutain, B, Labat, C, Mauras, Y, Gorgels, T.G, Bergen, A.A, Le Saux, O, Lacolley, P, Lefthériotis, G, Henrion, D, Martin, L

“…OBJECTIVE—Pseudoxanthoma elasticum is an inherited metabolic disorder resulting from ABCC6 gene mutations. It is characterized by progressive calcification and…”
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Tissue kallikrein is required for the cardioprotective effect of Cyclosporin A in myocardial ischemia in the mouse by Youcef, G., Belaidi, E., Waeckel, L., Fazal, L., Clemessy, M., Vincent, M.P., Zadigue, G., Richer, C., Alhenc-Gelas, F., Ovize, M., Pizard, A.

“…Clinical and experimental studies suggest that pharmacological postconditioning with Cyclosporin A (CsA) reduces infarct size in cardiac ischemia and…”
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N-linked glycosylation of the human bradykinin B2 receptor is required for optimal cell-surface expression and coupling by Michineau, Stéphanie, Muller, Laurent, Pizard, Anne, Alhenc-Gélas, François, Rajerison, Rabary M

“…To investigate the glycosylation of the human bradykinin B2 receptor and the functional significance of this modification, we studied receptors mutated at…”
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Palmitoylation of the Human Bradykinin B2 Receptor Influences Ligand Efficacy by Pizard, Anne, Blaukat, Andree, Michineau, Stéphanie, Dikic, Ivan, Müller-Esterl, Werner, Alhenc-Gelas, François, Rajerison, Rabary M

“…To investigate the palmitoylation of the human bradykinin B2 receptor, we have mutated individually or simultaneously into glycine two potential acylation…”
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Receptors for kinins in the human isolated umbilical vein by Gobeil, F., Pheng, L.H., Badini, I., Nguyen‐Le, X.K., Pizard, A., Rizzi, A., Blouin, D., Regoli, D.

“…1 The human umbilical vein has been found to contract in response to bradykinin (BK) and desArg9BK. 2 The rank order of potency of agonists, in the presence of…”
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I038 Influence des kinines sur les effets cardioet réno-vasculaires de la cyclosporine a by Fazal, L, Alhenc-Gelas, F, Pizard, A

“…La déficience génétique du Système Kallicréine Kinines (SKK) conduit à un dysfonctionnement artériel, cardiaque et rénal. Des observations faites chez l’homme…”
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Effect of eplerenone in patients with heart failure and reduced ejection fraction: potential effect modification by abdominal obesity. Insight from the EMPHASIS‐HF trial by Olivier, Arnaud, Pitt, Bertram, Girerd, Nicolas, Lamiral, Zohra, Machu, Jean‐Loup, McMurray, John J.V., Swedberg, Karl, van Veldhuisen, Dirk J., Collier, Timothy J., Pocock, Stuart J., Rossignol, Patrick, Zannad, Faiez, Pizard, Anne

“…Aims An excessive production of aldosterone influences outcome in patients with heart failure (HF) and in obese patients. Findings from laboratory studies…”
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The T-Box transcription factor Tbx5 is required for the patterning and maturation of the murine cardiac conduction system by Moskowitz, Ivan P G, Pizard, Anne, Patel, Vickas V, Bruneau, Benoit G, Kim, Jae B, Kupershmidt, Sabina, Roden, Dan, Berul, Charles I, Seidman, Christine E, Seidman, Jonathan G

“…We report a critical role for the T-box transcription factor Tbx5 in development and maturation of the cardiac conduction system. We find that Tbx5 is…”
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Transgenic mice overexpressing mutant PRKAG2 define the cause of wolff-parkinson-white syndrome in glycogen storage cardiomyopathy by ARAD, Michael, MOSKOWITZ, Ivan P, STAPLETON, David, SCHMITT, Joachim P, GUO, X. X, PIZARD, Anne, KUPERSHMIDT, Sabina, RODEN, Dan M, BERUL, Charles I, SEIDMAN, Christine E, SEIDMAN, J. G, PATEL, Vickas V, AHMAD, Ferhaan, PEREZ-ATAYDE, Antonio R, SAWYER, Douglas B, WALTER, Mark, LI, Guo H, BURGON, Patrick G, MAGUIRE, Colin T

“…Mutations in the gamma2 subunit (PRKAG2) of AMP-activated protein kinase produce an unusual human cardiomyopathy characterized by ventricular hypertrophy and…”
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Mutation in the transcriptional coactivator EYA4 causes dilated cardiomyopathy and sensorineural hearing loss by Seidman, Christine E, Schönberger, Jost, Wang, Libin, Shin, Jordan T, Kim, Sang Do, Depreux, Frederic F S, Zhu, Hao, Zon, Leonard, Pizard, Anne, Kim, Jae B, MacRae, Calum A, Mungall, Andy J, Seidman, J G

“…We identified a human mutation that causes dilated cardiomyopathy and heart failure preceded by sensorineural hearing loss (SNHL). Unlike previously described…”
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Bradykinin-induced internalization of the human B2 receptor requires phosphorylation of three serine and two threonine residues at its carboxyl tail by Pizard, A, Blaukat, A, Müller-Esterl, W, Alhenc-Gelas, F, Rajerison, R M

“…The binding of bradykinin (BK) to B2 receptor triggers the internalization of the agonist-receptor complex. To investigate the mechanisms and the receptor…”
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Determination of Bradykinin B2 Receptor in Vivo Phosphorylation Sites and Their Role in Receptor Function by Blaukat, Andree, Pizard, Anne, Breit, Andreas, Wernstedt, Christer, Alhenc-Gelas, François, Müller-Esterl, Werner, Dikic, Ivan

“…Reversible phosphorylation plays important roles in G protein-coupled receptor signaling, desensitization, and endocytosis, yet the precise location and role…”
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Loss-of-function polymorphism of the human Kallikrein gene with reduced urinary kallikrein activity by SLIM, Rola, TORREMOCHA, Florence, MOREAU, Thierry, PIZARD, Anne, HUNT, Steven C, VUAGNAT, Albert, WILLIAMS, Gordon H, GAUTHIER, Francis, JEUNEMAITRE, Xavier, ALHENC-GELAS, Francois

“…Kallikrein is synthesized in the distal tubules and produces kinins, which are involved in the regulation of vascular tone in the kidney. Urinary kallikrein…”
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A Novel Protein-Protein Interaction between a G Protein-coupled Receptor and the Phosphatase SHP-2 Is Involved in Bradykinin-induced Inhibition of Cell Proliferation by Duchene, Johan, Schanstra, Joost P, Pecher, Christiane, Pizard, Anne, Susini, Christiane, Esteve, Jean-Pierre, Bascands, Jean-Loup, Girolami, Jean-Pierre

“…Mitogenic G protein-coupled receptor (GPCR) signaling has been extensively studied. In contrast, little is known about anti-mitogenic GPCR signaling. We show…”
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Palmitoylation of the Human Bradykinin B 2 Receptor Influences Ligand Efficacy by Pizard, Anne, Blaukat, Andree, Michineau, Stéphanie, Dikic, Ivan, Müller-Esterl, Werner, Alhenc-Gelas, François, Rajerison, Rabary M.

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Negative cooperativity in the human bradykinin B2 receptor by Pizard, A, Marchetti, J, Allegrini, J, Alhenc-Gelas, F, Rajerison, R M

“…A human kidney bradykinin (BK) B2 receptor cDNA was transfected in CHO-K1 cells to establish cell lines that express stably and at high density a receptor…”
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Activation of mitogen-activated protein kinase by the bradykinin B 2 receptor is independent of receptor phosphorylation and phosphorylation-triggered internalization by Blaukat, Andree, Pizard, Anne, Rajerison, Rabary M., Alhenc-Gelas, François, Müller-Esterl, Werner, Dikic, Ivan

“…Recent evidence suggests that serine/threonine phosphorylation and internalization of β 2-adrenergic receptors play critical roles in signalling to the…”
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Activation of mitogen‐activated protein kinase by the bradykinin B2 receptor is independent of receptor phosphorylation and phosphorylation‐triggered internalization by Blaukat, Andree, Pizard, Anne, Rajerison, Rabary M., Alhenc-Gelas, François, Müller-Esterl, Werner, Dikic, Ivan

“…Recent evidence suggests that serine/threonine phosphorylation and internalization of β2‐adrenergic receptors play critical roles in signalling to the…”
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Bradykinin-induced Internalization of the Human B sub(2) Receptor Requires Phosphorylation of Three Serine and Two Threonine Residues at Its Carboxyl Tail by Pizard, A, Blaukat, A, Mueller-Esterl, W, Alhenc-Gelas, F, Rajerison, R M

“…The binding of bradykinin (BK) to B sub(2) receptor triggers the internalization of the agonist-receptor complex. To investigate the mechanisms and the…”
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