Search Results - "Piunti, Andrea"

The roles of Polycomb repressive complexes in mammalian development and cancer by Piunti, Andrea, Shilatifard, Ali

“…More than 80 years ago, the first Polycomb-related phenotype was identified in Drosophila melanogaster . Later, a group of diverse genes collectively called…”
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Epigenetic balance of gene expression by Polycomb and COMPASS families by Piunti, Andrea, Shilatifard, Ali

“…Epigenetic regulation of gene expression in metazoans is central for establishing cellular diversity, and its deregulation can result in pathological…”
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Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer by Piunti, Andrea, Shilatifard, Ali

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Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas by Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali

“…Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however,…”
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Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation by Douillet, Delphine, Sze, Christie C., Ryan, Caila, Piunti, Andrea, Shah, Avani P., Ugarenko, Michal, Marshall, Stacy A., Rendleman, Emily J., Zha, Didi, Helmin, Kathryn A., Zhao, Zibo, Cao, Kaixiang, Morgan, Marc A., Singer, Benjamin D., Bartom, Elizabeth T., Smith, Edwin R., Shilatifard, Ali

“…The COMPASS protein family catalyzes histone H3 Lys 4 (H3K4) methylation and its members are essential for regulating gene expression. MLL2/COMPASS methylates…”
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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability by Rickels, Ryan, Herz, Hans-Martin, Sze, Christie C, Cao, Kaixiang, Morgan, Marc A, Collings, Clayton K, Gause, Maria, Takahashi, Yoh-hei, Wang, Lu, Rendleman, Emily J, Marshall, Stacy A, Krueger, Annika, Bartom, Elizabeth T, Piunti, Andrea, Smith, Edwin R, Abshiru, Nebiyu A, Kelleher, Neil L, Dorsett, Dale, Shilatifard, Ali

“…Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants…”
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Detection of Histone H3 mutations in cerebrospinal fluid-derived tumor DNA from children with diffuse midline glioma by Huang, Tina Y, Piunti, Andrea, Lulla, Rishi R, Qi, Jin, Horbinski, Craig M, Tomita, Tadanori, James, C David, Shilatifard, Ali, Saratsis, Amanda M

“…Diffuse midline gliomas (including diffuse intrinsic pontine glioma, DIPG) are highly morbid glial neoplasms of the thalamus or brainstem that typically arise…”
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Decoding the protein composition of whole nucleosomes with Nuc-MS by Schachner, Luis F., Jooß, Kevin, Morgan, Marc A., Piunti, Andrea, Meiners, Matthew J., Kafader, Jared O., Lee, Alexander S., Iwanaszko, Marta, Cheek, Marcus A., Burg, Jonathan M., Howard, Sarah A., Keogh, Michael-Christopher, Shilatifard, Ali, Kelleher, Neil L.

“…Current proteomic approaches disassemble and digest nucleosome particles, blurring readouts of the ‘histone code’. To preserve nucleosome-level information, we…”
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A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation by Morgan, Marc A J, Rickels, Ryan A, Collings, Clayton K, He, Xiaolin, Cao, Kaixiang, Herz, Hans-Martin, Cozzolino, Kira A, Abshiru, Nebiyu A, Marshall, Stacy A, Rendleman, Emily J, Sze, Christie C, Piunti, Andrea, Kelleher, Neil L, Savas, Jeffrey N, Shilatifard, Ali

“…Histone H3 Lys4 (H3K4) methylation is a chromatin feature enriched at gene -regulatory sequences such as promoters and enhancers. Here we identify an…”
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Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication by Piunti, Andrea, Rossi, Alessandra, Cerutti, Aurora, Albert, Mareike, Jammula, Sriganesh, Scelfo, Andrea, Cedrone, Laura, Fragola, Giulia, Olsson, Linda, Koseki, Haruhiko, Testa, Giuseppe, Casola, Stefano, Helin, Kristian, di Fagagna, Fabrizio d’Adda, Pasini, Diego

“…The ability of PRC1 and PRC2 to promote proliferation is a main feature that links polycomb (PcG) activity to cancer. PcGs silence the expression of the tumour…”
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TET2 coactivates gene expression through demethylation of enhancers by Wang, Lu, Ozark, Patrick A, Smith, Edwin R, Zhao, Zibo, Marshall, Stacy A, Rendleman, Emily J, Piunti, Andrea, Ryan, Caila, Whelan, Anna L, Helmin, Kathryn A, Morgan, Marc Alard, Zou, Lihua, Singer, Benjamin D, Shilatifard, Ali

“…The tet methylcytosine dioxygenase 2 (TET2) enzyme catalyzes the conversion of the modified DNA base 5-methylcytosine to 5-hydroxymethylcytosine. TET2 is…”
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Effects of H3.3G34V mutation on genomic H3K36 and H3K27 methylation patterns in isogenic pediatric glioma cells by Huang, Tina Yi-Ting, Piunti, Andrea, Qi, Jin, Morgan, Marc, Bartom, Elizabeth, Shilatifard, Ali, Saratsis, Amanda M

“…Histone H3.3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or valine (G34R/V),…”
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Isolation of Chromatin from Dysfunctional Telomeres Reveals an Important Role for Ring1b in NHEJ-Mediated Chromosome Fusions by Bartocci, Cristina, Diedrich, Jolene K., Ouzounov, Iliana, Li, Julia, Piunti, Andrea, Pasini, Diego, Yates, John R., Lazzerini Denchi, Eros

“…When telomeres become critically short, DNA damage response factors are recruited at chromosome ends, initiating a cellular response to DNA damage. We…”
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Critical Role for the Human Cytomegalovirus Major Immediate Early Proteins in Recruitment of RNA Polymerase II and H3K27Ac To an Enhancer-Like Element in OriLyt by Forte, Eleonora, Li, Ming, Ayaloglu Butun, Fatma, Hu, Qiaolin, Borst, Eva Maria, Schipma, Matthew J., Piunti, Andrea, Shilatifard, Ali, Terhune, Scott S., Abecassis, Michael, Meier, Jeffery L., Hummel, Mary

“…Human cytomegalovirus (HCMV) is an opportunistic pathogen that infects most of the population. The complex 236 kbp genome encodes more than 170 open reading…”
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PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes by Ponente, Manfredi, Campanini, Letizia, Cuttano, Roberto, Piunti, Andrea, Delledonne, Giacomo A, Coltella, Nadia, Valsecchi, Roberta, Villa, Alessandra, Cavallaro, Ugo, Pattini, Linda, Doglioni, Claudio, Bernardi, Rosa

“…Elucidating the molecular basis of tumor metastasis is pivotal for eradicating cancer-related mortality. Triple-negative breast cancer (TNBC) encompasses a…”
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Abstract A46: Heterotypic nucleosomes and PRC2 role in diffuse intrinsic pontine gliomas by Piunti, Andrea

“…Abstract Diffuse intrinsic pontine gliomas (DIPG) harbor a characteristic lysine-to-methionine mutation on histone H3 (H3K27M) that potently inhibits Polycomb…”
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Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice by Rossi, Alessandra, Ferrari, Karin J, Piunti, Andrea, Jammula, SriGanesh, Chiacchiera, Fulvio, Mazzarella, Luca, Scelfo, Andrea, Pelicci, Pier Giuseppe, Pasini, Diego

“…Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular and biochemical properties…”
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controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins? by Scelfo, Andrea, Piunti, Andrea, Pasini, Diego

“…Polycomb group proteins (PcGs) are a large protein family that includes diverse biochemical features assembled together in two large multiprotein complexes…”
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METB-01. EFFECTS OF H3.3G34V MUTATION ON GENOMIC H3K36 AND H3K27 METHYLATION PATTERNS IN ISOGENIC PEDIATRIC GLIOMA CELLS by Huang, Tina, Piunti, Andrea, Qi, Jin, Bartom, Elizabeth, Saratsis, Amanda

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Epigenetic factors in cancer development: polycomb group proteins by Piunti, Andrea, Pasini, Diego

“…The role of chromatin-modifying factors in cancer biology emerged exponentially in the last 10 years, and increased attention has been focused on Polycomb…”
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