Search Results - "Pitzer, Emily M"

Effects of pyrethroids on brain development and behavior: Deltamethrin by Pitzer, Emily M., Williams, Michael T., Vorhees, Charles V.

“…Deltamethrin (DLM) is a Type II pyrethroid pesticide widely used in agriculture, homes, public spaces, and medicine. Epidemiological studies report that…”
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Proteome Profiling of Rat Brain Cortical Changes during Early Postnatal Brain Development by Winnik, Witold M., Padgett, William, Pitzer, Emily M., Herr, David W.

“…Label-free quantitation (LFQ) was applied to proteome profiling of rat brain cortical development during the early postnatal period. Male and female rat brain…”
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Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers by Regan, Samantha L., Hufgard, Jillian R., Pitzer, Emily M., Sugimoto, Chiho, Hu, Yueh-Chiang, Williams, Michael T., Vorhees, Charles V.

“…Attention deficit hyperactivity disorder is a pervasive developmental disorder characterized by inattention, impulsivity, and hyperactivity and is 75–90%…”
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A novel role for the ADHD risk gene latrophilin-3 in learning and memory in Lphn3 knockout rats by Regan, Samantha L., Pitzer, Emily M., Hufgard, Jillian R., Sugimoto, Chiho, Williams, Michael T., Vorhees, Charles V.

“…Latrophilins (LPHNs) are adhesion G protein-coupled receptors with three isoforms but only LPHN3 is brain specific (caudate, prefrontal cortex, dentate,…”
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Cognitive and behavioral effects of whole brain conventional or high dose rate (FLASH) proton irradiation in a neonatal Sprague Dawley rat model by Williams, Michael T, Sugimoto, Chiho, Regan, Samantha L, Pitzer, Emily M, Fritz, Adam L, Sertorio, Mathieu, Mascia, Anthony E, Vatner, Ralph E, Perentesis, John P, Vorhees, Charles V

“…Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive…”
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Whole brain proton irradiation in adult Sprague Dawley rats produces dose dependent and non-dependent cognitive, behavioral, and dopaminergic effects by Williams, Michael T., Sugimoto, Chiho, Regan, Samantha L., Pitzer, Emily M., Fritz, Adam L., Mascia, Anthony E., Sertorio, Mathieu, Vatner, Ralph E., Perentesis, John P., Vorhees, Charles V.

“…Proton radiotherapy causes less off-target effects than X-rays but is not without effect. To reduce adverse effects of proton radiotherapy, a model of…”
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Developmental deltamethrin: Sex-specific hippocampal effects in Sprague Dawley rats by Pitzer, Emily M., Sugimoto, Chiho, Regan, Samantha L., Gudelsky, Gary A., Williams, Michael T., Vorhees, Charles V.

“…[Display omitted] •Low dose deltamethrin (DLM) effects have been reported in developing rodents.•Rats treated with DLM from P3-20 showed effects on NMDA-NR2A…”
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Identification of neurotoxicology (NT)/developmental neurotoxicology (DNT) adverse outcome pathways and key event linkages with in vitro DNT screening assays by Pitzer, Emily M, Shafer, Timothy J, Herr, David W

“…There is a need to assess compounds reliably and quickly for neurotoxicity (NT) and developmental neurotoxicity (DNT). Adverse outcome pathways (AOPs) enable…”
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Deltamethrin Exposure Daily From Postnatal Day 3–20 in Sprague-Dawley Rats Causes Long-term Cognitive and Behavioral Deficits by Pitzer, Emily M, Sugimoto, Chiho, Gudelsky, Gary A, Huff Adams, Courtney L, Williams, Michael T, Vorhees, Charles V

“…Abstract Pyrethroids are synthetic insecticides that act acutely on voltage gated sodium channels to prolong channel opening and depolarization…”
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Adolescent Rats Self-Administer Less Nicotine Than Adults at Low Doses by Schassburger, Rachel L., Pitzer, Emily M., Smith, Tracy T., Rupprecht, Laura E., Thiels, Edda, Donny, Eric C., Sved, Alan F.

“…Although nearly 90% of current smokers initiated tobacco use during adolescence, little is known about reinforcement by nicotine in adolescents. Researchers…”
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Prenatal exposure to PCBs in Cyp1a2 knock-out mice interferes with F 1 fertility, impairs long-term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects by Hufgard, Jillian R, Sprowles, Jenna L N, Pitzer, Emily M, Koch, Sheryl E, Jiang, Min, Wang, Qin, Zhang, Xiang, Biesiada, Jacek, Rubinstein, Jack, Puga, Alvaro, Williams, Michael T, Vorhees, Charles V

“…Polychlorinated biphenyls (PCBs) are toxic environmental pollutants. Humans are exposed to PCB mixtures via contaminated food or water. PCB exposure causes…”
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Prenatal exposure to PCBs in Cyp1a2 knock‐out mice interferes with F1 fertility, impairs long‐term potentiation, reduces acoustic startle and impairs conditioned freezing contextual memory with minimal transgenerational effects by Hufgard, Jillian R., Sprowles, Jenna L.N., Pitzer, Emily M., Koch, Sheryl E., Jiang, Min, Wang, Qin, Zhang, Xiang, Biesiada, Jacek, Rubinstein, Jack, Puga, Alvaro, Williams, Michael T., Vorhees, Charles V.

“…Polychlorinated biphenyls (PCBs) are toxic environmental pollutants. Humans are exposed to PCB mixtures via contaminated food or water. PCB exposure causes…”
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Cognitive and behavioral effects of whole brain conventional or high dose rate by Williams, Michael T, Sugimoto, Chiho, Regan, Samantha L, Pitzer, Emily M, Fritz, Adam L, Sertorio, Mathieu, Mascia, Anthony E, Vatner, Ralph E, Perentesis, John P, Vorhees, Charles V

“…Recent studies suggest that ultra-high dose rates of proton radiation (>40 Gy/s; FLASH) confer less toxicity to exposed healthy tissue and reduce cognitive…”
Get full text

3174: Effects of whole brain conventional or FLASH proton irradiation in Sprague Dawley rats by Vorhees, Charles V., Sugimoto, Chiho, Regan, Samantha L., Pitzer, Emily M., Fritz, Adam L., Gollaway, Brooke M., Sertorio, Mathieu, Mascia, Anthony E., Vatner, Ralph E., Parentesis, John P., Williams, Michael T.

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