Search Results - "Pitzenberger, S M"

High Fatty Acid Content in Rabbit Serum Is Responsible for the Differentiation of Osteoblasts Into Adipocyte‐like Cells by Diascro, Dominic D., Vogel, Robert L., Johnson, Timothy E., Witherup, Keith M., Pitzenberger, Steven M., Rutledge, Su Jane, Prescott, David J., Rodan, Gideon A., Schmidt, Azriel

“…Osteoblasts and adipocytes originate from common mesenchymal precursors. With aging, there is a decrease in osteoprogenitor cells that parallels an increase of…”
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In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase by Vickers, S, Duncan, C A, Vyas, K P, Kari, P H, Arison, B, Prakash, S R, Ramjit, H G, Pitzenberger, S M, Stokker, G, Duggan, D E

“…Simvastatin (SV), an analog of lovastatin, is the lactone form of 1', 2', 6', 7', 8', 8a'-hexahydro-3,5-dihydroxy-2', 6'-dimethyl-8' (2",…”
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Chemical Synthesis of Echistatin, a Potent Inhibitor of Platelet Aggregation from Echis carinatus: Synthesis and Biological Activity of Selected Analogs by Garsky, Victor M., Lumma, Patricia K., Freidinger, Roger M., Pitzenberger, Steven M., Randall, William C., Veber, Daniel F., Gould, Robert J., Friedman, Paul A.

“…Echistatin, a polypeptide from the venom of the saw-scaled viper, Echis carinatus, containing 49 amino acids and 4 cystine bridges was synthesized by…”
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Characterization of a solid state reaction product from a lyophilized formulation of a cyclic heptapeptide. A novel example of an excipient-induced oxidation by DUBOST, D. C, KAUFMAN, M. J, ZIMMERMAN, J. A, BOGUSKY, M. J, CODDINGTON, A. B, PITZENBERGER, S. M

“…To elucidate the structure of a degradation product arising from a lyophilized formulation of a cyclic heptapeptide, and to provide a mechanism to account for…”
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Antibacterial Activity of Lonchocarpol A by Salvatore, Michael J, King, Aurora B, Graham, Amy C, Onishi, H. Russell, Bartizal, Kenneth F, Abruzzo, George K, Gill, Charles J, Ramjit, Harri G, Pitzenberger, Steven M, Witherup, Keith M

“…Lonchocarpol A, a flavanone, demonstrates in vitro inhibitory activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant…”
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Hepatic metabolism of spironolactone. Production of 3-hydroxy-thiomethyl metabolites by Los, L E, Pitzenberger, S M, Ramjit, H G, Coddington, A B, Colby, H D

“…Spironolactone (SP) is used clinically as a renal aldosterone antagonist and as an antiandrogen. It is known that the drug is extensively metabolized and that…”
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Metabolism of L-689,502 by rat liver slices to potent HIV-1 protease inhibitors by Balani, S K, Pitzenberger, S M, Schwartz, M S, Ramjit, H G, Thompson, W J

“…L-689,502, N-[2(R)-hydroxy-1(S)-indanyl]-5(S)-(1,1-dimethylethoxy- carbonyl-amino)-4(S)-hydroxy-6-phenyl-2(R)-(4-[2(R)-(4-morpholinyl)…”
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Physiological disposition and metabolism of L-365,260, a potent antagonist of brain cholecystokinin receptor, in laboratory animals by Chen, I W, Dorley, J M, Ramjit, H G, Pitzenberger, S M, Lin, J H

“…L-365,260 [3R(+)-N-(2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4- benzodiazepine-3-yl)-N'-(3-methylphenylurea)], a potent nonpeptide antagonist of the CCKB…”
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NMR studies of novel inhibitors bound to farnesyl‐protein transferase by Koblan, Kenneth S., Mosser, Scott D., Omer, Charles A., Christopher Culberson, J., Jane Desolms, S., Giuliani, Elizabeth A., Pitzenberger, Steven M., Bogusky, Michael J.

“…Farnesyl‐protein transferase (FPTase) catalyzes the posttranslational farnesylation of the cysteine residue located in the carboxyl‐terminal tetrapeptide of…”
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Proton NMR assignments and secondary structure of the snake venom protein echistatin by Chen, Yuan, Pitzenberger, Steven M, Garsky, Victor M, Lumma, Patricia K, Sanyal, Gautam, Baum, Jean

“…The snake venom protein echistatin is a potent inhibitor of platelet aggregation. The inhibitory properties of echistatin have been attributed to the…”
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Metabolism of a new HIV-1 reverse transcriptase inhibitor, 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (L-696,229), in rat and liver slices by Balani, S K, Pitzenberger, S M, Kauffman, L R, Arison, B H, Ramjit, H G, Goldman, M E, O'Brien, J A, King, J D, Hoffman, J M, Rooney, C S

“…L-696,229 is a potent and specific inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and is currently undergoing clinical…”
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Biotransformation of lovastatin. I. Structure elucidation of in vitro and in vivo metabolites in the rat and mouse by Vyas, K P, Kari, P H, Pitzenberger, S M, Halpin, R A, Ramjit, H G, Arison, B, Murphy, J S, Hoffman, W F, Schwartz, M S, Ulm, E H

“…Structures of in vitro microsomal and in vivo metabolites of lovastatin, a new cholesterol-lowering drug, were elucidated with the combined application of…”
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In vivo and in vitro metabolism studies on a class III antiarrhythmic agent by Vickers, S, Duncan, C A, Kari, P H, Homnick, C F, Elliott, J M, Pitzenberger, S M, Hichens, M, Vyas, K P

“…The metabolism of L-691,121 (I), a class III antiarrhythmic agent, was studied in vivo in rats and dogs and in vitro by using liver S9 or slices from these…”
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Biotransformation of 5-chloro-3-phenylthioindole-2-carboxamide (L-734,005) in rhesus monkeys and rat liver microsomes to a potent HIV-1 reverse transcriptase inhibitor by Balani, S K, Goldman, M E, Kauffman, L R, Varga, S L, O'Brien, J A, Smith, S J, Olah, T V, Ramjit, H G, Schorn, T W, Pitzenberger, S M

“…Rhesus monkeys were dosed orally with 10 mg/kg 5-chloro-3-phenylthioindole-2-carboxamide (L-734,005), a nonnucleoside human immunodeficiency virus type 1…”
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Metabolism of antiparkinson agent dopazinol by rat liver microsomes by Vyas, K P, Kari, P H, Ramjit, H G, Pitzenberger, S M, Hichens, M

“…Metabolism of dopazinol (DZ) by liver microsomes from control and phenobarbital- and 3-methylcholanthrene-treated rats has been investigated. Liver microsomes…”
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NMR and molecular modeling characterization of RGD containing peptides by Bogusky, M J, Naylor, A M, Pitzenberger, S M, Nutt, R F, Brady, S F, Colton, C D, Sisko, J T, Anderson, P S, Veber, D F

“…The tripeptide sequence arginine-glycine-aspartic acid (RGD) has been shown to be the key recognition segment in numerous cell adhesion proteins. The solution…”
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Disposition and metabolism of sodium 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma -oxobenzenebutanoate in rats and dogs by Tocco, D J, deLuna, F A, Duncan, A E, Ramjit, H G, Pitzenberger, S M, Hsieh, J Y

“…The disposition of sodium 4-[(3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)sulfonyl]-gamma-o xo benzenebutanoate (L-648,051) was determined in rats and dogs…”
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Conformation of a novel tetrapeptide inhibitor NH2-d-Trp-d-Met-Phe(pCl)-Gla-NH2 bound to farnesyl-protein transferase by Bogusky, M.J., Pitzenberger, S.M., Garsky, V.M., Culberson, J.C., Koblan, K.S., Wallace, A., Pessi, A.

“…: Farnesyl‐protein transferase (FPTase) catalyzes the post‐translational farnesylation of the cysteine residue located in the C‐terminal tetrapeptide of the…”
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The solution conformation of Ac-Pen-Arg-Gly-Asp-Cys-OH, a potent fibrinogen receptor antagonist by Bogusky, M J, Naylor, A M, Mertzman, M E, Pitzenberger, S M, Nutt, R F, Brady, S F, Colton, C D, Veber, D F

“…The solution conformation of Ac-Pen-Arg-Gly-Asp-Cys-OH, a potent fibrinogen receptor antagonist, was characterized in DMSO-d6 by the combination of nmr and…”
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Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans by Balani, S K, Kauffman, L R, Arison, B H, Olah, T V, Goldman, M E, Varga, S L, O'Brien, J A, Ramjit, H G, Rooney, C S, Hoffman, J M

“…Healthy subjects were administered single oral doses of 800 mg or 400 mg 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-o ne (L-696,229), a…”
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