Search Results - "Pitzele, B S"

2-Iminopyrrolidines as Potent and Selective Inhibitors of Human Inducible Nitric Oxide Synthase by Hagen, Timothy J, Bergmanis, Arija A, Kramer, Steven W, Fok, Kam F, Schmelzer, Albert E, Pitzele, Barnett S, Swenton, Lydia, Jerome, Gina M, Kornmeier, Christine M, Moore, William M, Branson, Linda F, Connor, Jane R, Manning, Pamela T, Currie, Mark G, Hallinan, E. Ann

“…A series of substituted 2-iminopyrrolidines has been prepared and shown to be potent and selective inhibitors of the human inducible nitric oxide synthase…”
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Substituted 2-Iminopiperidines as Inhibitors of Human Nitric Oxide Synthase Isoforms by Webber, R. Keith, Metz, Suzanne, Moore, William M, Connor, Jane R, Currie, Mark G, Fok, Kam F, Hagen, Timothy J, Hansen, Donald W, Jerome, Gina M, Manning, Pamela T, Pitzele, Barnett S, Toth, Mihaly V, Trivedi, Mahima, Zupec, Mark E, Tjoeng, F. Siong

“…A series of analogues of 2-iminopiperidine have been prepared and shown to be potent inhibitors of the human nitric oxide synthase (NOS) isoforms. Methyl…”
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Acetamidine Lysine Derivative, N-(5(S)-amino-6,7-dihydroxyheptyl)ethanimidamide Dihydrochloride:  A Highly Selective Inhibitor of Human Inducible Nitric Oxide Synthase by Hallinan, E. Ann, Tsymbalov, Sofya, Finnegan, Patricia M, Moore, William M, Jerome, Gina M, Currie, Mark G, Pitzele, Barnett S

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2-Iminohomopiperidinium Salts as Selective Inhibitors of Inducible Nitric Oxide Synthase (iNOS) by Hansen, Donald W, Peterson, Karen B, Trivedi, Mahima, Kramer, Steven W, Webber, Ronald K, Tjoeng, Foe S, Moore, William M, Jerome, Gina M, Kornmeier, Christine M, Manning, Pamela T, Connor, Jane R, Misko, Thomas P, Currie, Mark G, Pitzele, Barnett S

“…An attractive approach to the treatment of inflammatory conditions such as osteo- and rheumatoid arthritis, inflammatory bowel disease, and sepsis is through…”
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Selective heterocyclic amidine inhibitors of human inducible nitric oxide synthase by Moormann, Alan E, Metz, Sue, Toth, Mihaly V, Moore, William M, Jerome, Gina, Kornmeier, Christine, Manning, Pamela, Hansen, Donald W, Pitzele, Barnett S, Webber, R.K

“…The potency and selectivity of a series of 5-hetero-2-iminohexahydroazepines were examined as inhibitors of the three human NOS isoforms. The effect of ring…”
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Potential antisecretory antidiarrheals. 2. Alpha 2-adrenergic 2-[(aryloxy)alkyl]imidazolines by Moormann, A E, Pitzele, B S, Jones, P H, Gullikson, G W, Albin, D, Yu, S S, Bianchi, R G, Sanguinetti, E L, Rubin, B, Grebner, M

“…Lofexidine, an alpha 2-agonist, has central hypotensive activity and peripheral intestinal antisecretory activity. Analogues were synthesized with increased…”
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The N-Boc group as an activator for the α-lithiation of carbamates: synthesis of 11-substituted dibenzoxazepines by HAGEN, T. J, RAFFERTY, M. F, COLLINS, J. T, GARLAND, D. J, LI, J. J, NORTON, M. B, REITZ, D. B, TSYMBALOV, S, PITZELE, B. S, HALLINAN, E. A

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Potential antisecretory antidiarrheals. 1. Alpha 2-adrenergic aromatic aminoguanidine hydrazones by Pitzele, B S, Moormann, A E, Gullikson, G W, Albin, D, Bianchi, R G, Palicharla, P, Sanguinetti, E L, Walters, D E

“…Guanabenz, a centrally acting antihypertensive agent, has been shown to have intestinal antisecretory properties. A series of aromatic aminoguanidine…”
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Synthesis and Biological Characterization of L-N 6 -(1-Iminoethyl)lysine 5-Tetrazole-amide, a Prodrug of a Selective iNOS Inhibitor by Hallinan, E. Ann, Tsymbalov, Sofya, Dorn, Clifford R., Pitzele, Barnett S., Hansen, Donald W., Moore, William M., Jerome, Gina M., Connor, Jane R., Branson, Linda F., Widomski, Deborah L., Zhang, Yan, Currie, Mark G., Manning, Pamela T.

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Synthesis of 2-oxygenated glycyrrhetic acid derivatives by Pitzele, Barnett S

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Synthesis and biological activities of substituted glycyrrhetic acids by Baran, John S, Langford, Donna D, Liang, Chi D, Pitzele, Barnett S

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4-Fluorinated L-lysine analogs as selective i-NOS inhibitors: methodology for introducing fluorine into the lysine side chain by Hallinan, E Ann, Kramer, Steven W, Houdek, Stephen C, Moore, William M, Jerome, Gina M, Spangler, Dale P, Stevens, Anna M, Shieh, Huey S, Manning, Pamela T, Pitzele, Barnett S

“…In the literature, the introduction of fluorine into bioactive molecules has been known to enhance the biological activity relative to the parent molecule…”
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5-Fluorinated l-Lysine Analogues as Selective Induced Nitric Oxide Synthase Inhibitors by Hallinan, E. Ann, Hagen, Timothy J, Bergmanis, Arija, Moore, William M, Jerome, Gina M, Spangler, Dale P, Stevens, Anna M, Shieh, Huey S, Manning, Pamela T, Pitzele, Barnett S

“…5(S)-Fluoro-N6-(iminoethyl)-l -lysine ( 14), an analogue of the potent, selective induced nitric oxide synthase (iNOS) inhibitor iminoethyl-l-lysine (1), was…”
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Enkephalin Analogs as Systemically Active Antinociceptive Agents: O- and N-Alkylated Derivatives of the Dipeptide Amide L-2,6-Dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide by Pitzele, Barnett S, Hamilton, Robert W, Kudla, Kathleen D, Tsymbalov, Sofya, Stapelfeld, Awilda, Savage, Michael A, Clare, Michael, Hammond, Donna L, Hansen, Donald W

“…A number of O- and N-alkylated derivatives of the antinociceptive, orally active, mu-opioid-selective truncated enkephalin analog…”
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3-Hydroxy-4-methyl-5-pentyl-2-iminopyrrolidine: A potent and highly selective inducible nitric oxide synthase inhibitor by Tsymbalov, Sofya, Hagen, Timothy J., Moore, William M., Jerome, Gina M., Connor, Jane R., Manning, Pamela T., Pitzele, Barnett S., Hallinan, E.Ann

“…(3 S,4 S,5 R)-2-Imino-4-methyl-5-pentyl-3-pyrrolidinol hydrochloride ( 1) is a potent inducible nitric oxide synthase (i-NOS) inhibitor that has three times…”
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Enkephalin analogs as systemically active antinociceptive agents : O- and N-alkylated derivatives of the dipeptide amine L-2,6-dimethyltyrosyl-N-(3-phenylpropyl)-D-alaninamide by PITZELE, B. S, HAMILTON, R. W, KUDLA, K. D, TSYMBALOV, S, STAPELFELD, A, SAVAGE, M. A, CLARE, M, HAMMOND, D. L, HANSEN, D. W

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The synthesis of 6-trifluoroethyl- l-lysine: a method to introduce functionality at C-6 of l-lysine by Hallinan, E.Ann, Dorn, Clifford R., Moore, William M., Jerome, Gina M., Manning, Pamela T., Pitzele, Barnett S.

“…Described is a method of introducing trifluoroalkyl groups at C-6 of lysine. This chemistry has the potential to introduce a variety of functionality at C-6 of…”
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Potential antisecretory antidiarrheals. 2. alpha sub(2)-adrenergic 2-((aryloxy)alkyl) imidazolines by Moormann, A E, Pitzele, B S, Jones, PH, Gullikson, G W, Albin, D, Yu, S S, Bianchi, R G, Sanguinetti, EL, Rubin, B

“…Lofexidine, an alpha sub(2)-agonist, has central hypotensive activity and peripheral intestinal antisecretory activity. Analogues were synthesized with…”
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Potential antisecretory antidiarrheals. II: α2-adrenergic 2-[(aryloxy)alkyl]imidazolines by MOORMANN, A. E, PITZELE, B. S, MONROY, M, KELLAR, P, CASLER, J, JONES, P. H, GULLIKSON, G. W, ALBIN, D, YU, S. S, BIANCHI, R. G, SANGUINETTI, E. L, RUBIN, B, GREBNER, M

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Potential antisecretory antidiarrheals. I: α2-Adrenergic aromatic aminoguanidine hydrazones by PITZELE, B. S, MOORMANN, A. E, GULLIKSON, G. W, ALBIN, D, BIANCHI, R. G, PALICHARLA, P, SANGUINETTI, E. L, WALTERS, D. E

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