Search Results - "Pitzalis, Costantino"

Lactate at the crossroads of metabolism, inflammation, and autoimmunity by Pucino, Valentina, Bombardieri, Michele, Pitzalis, Costantino, Mauro, Claudio

“…For a long time after its discovery at the beginning of the 20th century, lactate was considered a waste product of cellular metabolism. Starting in the early…”
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Ectopic lymphoid neogenesis in rheumatic autoimmune diseases by Bombardieri, Michele, Lewis, Myles, Pitzalis, Costantino

“…Key Points Ectopic lymphoid structures (ELSs) develop in the target organs of a subset of patients with rheumatic autoimmune diseases and recapitulate key…”
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Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer by Nerviani, Alessandra, Pitzalis, Costantino

“…Ectopic (or tertiary) lymphoid structures (ELS) are organized aggregates of lymphocytes resembling secondary lymphoid organs and developing in chronically…”
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Ectopic lymphoid-like structures in infection, cancer and autoimmunity by Pitzalis, Costantino, Jones, Gareth W., Bombardieri, Michele, Jones, Simon A.

“…Key Points Ectopic lymphoid-like structure neogenesis is a common clinical occurrence and contributes to the pathology that is associated with cancer,…”
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Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs by Corsiero, Elisa, Bombardieri, Michele, Carlotti, Emanuela, Pratesi, Federico, Robinson, William, Migliorini, Paola, Pitzalis, Costantino

“…Rheumatoid arthritis (RA) is characterised by breach of self-tolerance towards citrullinated antigens with generation of anti-citrullinated peptide/proteins…”
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Ectopic Lymphoid Structures: Powerhouse of Autoimmunity by Corsiero, Elisa, Nerviani, Alessandra, Bombardieri, Michele, Pitzalis, Costantino

“…Ectopic lymphoid structures (ELS) often develop at sites of inflammation in target tissues of autoimmune diseases, such as rheumatoid arthritis, Sjögren's…”
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New learnings on the pathophysiology of RA from synovial biopsies by Pitzalis, Costantino, Kelly, Stephen, Humby, Frances

“…PURPOSE OF REVIEWTo critically appraise the literature related to the pathophysiology of rheumatoid arthritis (RA) focusing on the contribution of synovial…”
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Role of the IL-23/IL-17 Axis in Psoriasis and Psoriatic Arthritis: The Clinical Importance of Its Divergence in Skin and Joints by Boutet, Marie-Astrid, Nerviani, Alessandra, Gallo Afflitto, Gabriele, Pitzalis, Costantino

“…Psoriasis is a chronic systemic inflammatory disease causing erythematosus and scaly skin plaques; up to 30% of patients with psoriasis develop Psoriatic…”
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M3C: Monte Carlo reference-based consensus clustering by John, Christopher R., Watson, David, Russ, Dominic, Goldmann, Katriona, Ehrenstein, Michael, Pitzalis, Costantino, Lewis, Myles, Barnes, Michael

“…Genome-wide data is used to stratify patients into classes for precision medicine using clustering algorithms. A common problem in this area is selection of…”
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IL-36, IL-37, and IL-38 Cytokines in Skin and Joint Inflammation: A Comprehensive Review of Their Therapeutic Potential by Boutet, Marie-Astrid, Nerviani, Alessandra, Pitzalis, Costantino

“…The interleukin (IL)-1 family of cytokines is composed of 11 members, including the most recently discovered IL-36α, β, γ, IL-37, and IL-38. Similar to IL-1,…”
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Transforming clinical trials in rheumatology: towards patient-centric precision medicine by Pitzalis, Costantino, Choy, Ernest H. S., Buch, Maya H.

“…Despite the success of targeted therapies in the treatment of inflammatory arthritides, the lack of predictive biomarkers drives a ‘trial and error’ approach…”
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Spectrum: fast density-aware spectral clustering for single and multi-omic data by John, Christopher R, Watson, David, Barnes, Michael R, Pitzalis, Costantino, Lewis, Myles J

“…Abstract Motivation Clustering patient omic data is integral to developing precision medicine because it allows the identification of disease subtypes. A…”
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B cells in the formation of tertiary lymphoid organs in autoimmunity, transplantation and tumorigenesis by Corsiero, Elisa, Delvecchio, Francesca Romana, Bombardieri, Michele, Pitzalis, Costantino

“…•TLS develop in target organs of autoimmune diseases, transplantation and cancer.•TLS can function as germinal centres supporting B-cell…”
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CD40L-Dependent Pathway Is Active at Various Stages of Rheumatoid Arthritis Disease Progression by Guo, Yanxia, Walsh, Alice M, Fearon, Ursula, Smith, Malcolm D, Wechalekar, Mihir D, Yin, Xuefeng, Cole, Suzanne, Orr, Carl, McGarry, Trudy, Canavan, Mary, Kelly, Stephan, Lin, Tai-An, Liu, Xuejun, Proudman, Susanna M, Veale, Douglas J, Pitzalis, Costantino, Nagpal, Sunil

“…The inflammatory CD40-CD40L pathway is implicated in various autoimmune diseases, but the activity status of this pathway in various stages of rheumatoid…”
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Generation of restriction endonucleases barcode map to trace SARS-CoV-2 origin and evolution by Colombo, Federico, Corsiero, Elisa, Lewis, Myles J., Pitzalis, Costantino

“…Since the first report of SARS-CoV-2 in China in 2019, there has been a huge debate about the origin. In this work, using a different method we aimed to…”
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Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells by Rauber, Simon, Luber, Markus, Weber, Stefanie, Maul, Lisa, Soare, Alina, Wohlfahrt, Thomas, Lin, Neng-Yu, Dietel, Katharina, Bozec, Aline, Herrmann, Martin, Kaplan, Mark H, Weigmann, Benno, Zaiss, Mario M, Fearon, Ursula, Veale, Douglas J, Cañete, Juan D, Distler, Oliver, Rivellese, Felice, Pitzalis, Costantino, Neurath, Markus F, McKenzie, Andrew N J, Wirtz, Stefan, Schett, Georg, Distler, Jörg H W, Ramming, Andreas

“…Number of IL-9-expressing ILC2s are elevated in patients with inflammatory arthritis during remission, and these cells are critical in mice for the resolution…”
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Secondary and ectopic lymphoid tissue responses in rheumatoid arthritis: from inflammation to autoimmunity and tissue damage/remodeling by Manzo, Antonio, Bombardieri, Michele, Humby, Frances, Pitzalis, Costantino

“…Rheumatoid arthritis is a chronic systemic inflammatory disease primarily affecting the synovium of diarthrodial joints. Despite the currently unknown…”
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Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis by Gomez, Esteban A., Colas, Romain A., Souza, Patricia R., Hands, Rebecca, Lewis, Myles J., Bessant, Conrad, Pitzalis, Costantino, Dalli, Jesmond

“…Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and…”
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The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis by Mattiola, Irene, Tomay, Federica, De Pizzol, Maria, Silva-Gomes, Rita, Savino, Benedetta, Gulic, Tamara, Doni, Andrea, Lonardi, Silvia, Astrid Boutet, Marie, Nerviani, Alessandra, Carriero, Roberta, Molgora, Martina, Stravalaci, Matteo, Morone, Diego, Shalova, Irina N., Lee, Yunquin, Biswas, Subhra K., Mantovani, Giovanna, Sironi, Marina, Pitzalis, Costantino, Vermi, William, Bottazzi, Barbara, Mantovani, Alberto, Locati, Massimo

“…The plasma membrane tetraspan molecule MS4A4A is selectively expressed by macrophage-lineage cells, but its function is unknown. Here we report that MS4A4A was…”
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Ectopic lymphoid structures support ongoing production of class-switched autoantibodies in rheumatoid synovium by Humby, Frances, Bombardieri, Michele, Manzo, Antonio, Kelly, Stephen, Blades, Mark C, Kirkham, Bruce, Spencer, Jo, Pitzalis, Costantino

“…Follicular structures resembling germinal centres (GCs) that are characterized by follicular dendritic cell (FDC) networks have long been recognized in…”
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