Search Results - "Pituch, Katarzyna C"
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Mesenchymal Stem Cells Successfully Deliver Oncolytic Virotherapy to Diffuse Intrinsic Pontine Glioma
Published in Clinical cancer research (15-03-2021)“…Diffuse intrinsic pontine glioma (DIPG) is among the deadliest of pediatric brain tumors. Radiotherapy is the standard-of-care treatment for DIPG, but offers…”
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Pharmacologic modulation of nasal epithelium augments neural stem cell targeting of glioblastoma
Published in Theranostics (01-01-2019)“…Glioblastoma (GBM) remains the most lethal and untreatable central nervous system malignancy. The challenges to devise novel and effective anti-tumor therapies…”
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Computed tomography findings in a cohort of 169 dogs with elbow dysplasia - a retrospective study
Published in BMC veterinary research (06-09-2021)“…Abstract Background Canine elbow dysplasia (CED) is a complex developmental skeletal disorder associated with a number of pathological conditions within the…”
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microRNA-219 Reduces Viral Load and Pathologic Changes in Theiler's Virus-Induced Demyelinating Disease
Published in Molecular therapy (07-03-2018)“…Analysis of microRNA (miR) expression in the central nervous system white matter of SJL mice infected with the BeAn strain of Theiler’s murine…”
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CCL2 Produced by the Glioma Microenvironment Is Essential for the Recruitment of Regulatory T Cells and Myeloid-Derived Suppressor Cells
Published in Cancer research (Chicago, Ill.) (01-10-2016)“…In many aggressive cancers, such as glioblastoma multiforme, progression is enabled by local immunosuppression driven by the accumulation of regulatory T cells…”
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Therapeutic targeting of tumor-associated myeloid cells synergizes with radiation therapy for glioblastoma
Published in Proceedings of the National Academy of Sciences - PNAS (19-11-2019)“…Tumor-associated myeloid cells (TAMCs) are key drivers of immunosuppression in the tumor microenvironment, which profoundly impedes the clinical response to…”
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Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma
Published in Molecular therapy (04-04-2018)“…In order to fully harness the potential of immunotherapy with chimeric antigen receptor (CAR)-modified T cells, pre-clinical studies must be conducted in…”
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Neural stem cells secreting bispecific T cell engager to induce selective antiglioma activity
Published in Proceedings of the National Academy of Sciences - PNAS (02-03-2021)“…Glioblastoma (GBM) is the most lethal primary brain tumor in adults. No treatment provides durable relief for the vast majority of GBM patients. In this study,…”
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GCN2 is essential for CD8+ T cell survival and function in murine models of malignant glioma
Published in Cancer Immunology, Immunotherapy (01-01-2020)“…Amino acid deprivation is a strategy that malignancies utilize to blunt anti-tumor T-cell immune responses. It has been proposed that amino acid insufficiency…”
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Dysfunction of Platelet-derived Growth Factor Receptor α (PDGFRα) Represses the Production of Oligodendrocytes from Arylsulfatase A-deficient Multipotential Neural Precursor Cells
Published in The Journal of biological chemistry (13-03-2015)“…The membrane-bound receptor for platelet-derived growth factor A (PDGFRα) is crucial for controlling the production of oligodendrocytes (OLs) for myelination,…”
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Local Application of Autologous Platelet-Rich Fibrin Patch (PRF-P) Suppresses Regulatory T Cell Recruitment in a Murine Glioma Model
Published in Molecular neurobiology (01-07-2019)“…The immunosuppressive microenvironment is one of the major factors promoting the growth of glioblastoma multiforme (GBM). Infiltration of CD4 + CD25 + Foxp3 +…”
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Dysfunction of Platelet-derived Growth Factor Receptor a (PDGFR alpha) Represses the Production of Oligodendrocytes from Arylsulfatase A-deficient Multipotential Neural Precursor Cells
Published in The Journal of biological chemistry (13-03-2015)“…The membrane-bound receptor for platelet-derived growth factor A (PDGFR alpha) is crucial for controlling the production of oligodendrocytes (OLs) for…”
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P08.46 Synergistic Therapeutic Efficacy via Immunomodulatory Platelet Rich Fibrin Patch (PRF-P) in Combination with Oncolytic Adenovirus for the Treatment of Glioma
Published in Neuro-oncology (Charlottesville, Va.) (01-05-2017)“…Introduction: Oncolytic virotherapy is an interesting approach for the treatment of cancer, including glioblastoma. Recent studies in this area suggest a…”
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