Developmental toxicity of purified fumonisin B1 in pregnant Syrian hamsters

Developmental toxicity of purified fumonisin B1 in pregnant Syrian hamsters

The purpose of this study was to characterize the developmental toxicity of fumonisin B1 (FB1), a mycotoxin produced by Fusarium moniliforme, on fetal Syrian hamsters. Fusarium moniliforme has been associated with a variety of diseases in animals and esophageal cancer in humans. Purified FB1 causes...

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Bibliographic Details
Published in:Journal of applied toxicology Vol. 18; no. 3; pp. 197 - 203
Main Authors: Penner, Jocelyn D., Casteel, Stan W., Pittman Jr, Louis, Rottinghaus, George E., Wyatt, Roger D.
Format: Journal Article
Language:English
Published: Chichester John Wiley & Sons, Ltd 01-05-1998
Wiley
Subjects:
Abnormalities, Drug-Induced - pathology
Animals
Biological and medical sciences
Carboxylic Acids - administration & dosage
Carboxylic Acids - pharmacology
Carboxylic Acids - toxicity
Cricetinae
developmental
Dose-Response Relationship, Drug
Embryology: invertebrates and vertebrates. Teratology
Embryonic and Fetal Development - drug effects
F. moniliforme
Female
Fetal Death - chemically induced
fumonisin
Fumonisins
Fundamental and applied biological sciences. Psychology
hamster
Medical sciences
Mesocricetus
Plant poisons toxicology
Pregnancy
Teratology. Teratogens
toxicity
Toxicology
Embryonic development
Toxicity
Rodentia
Mycotoxin
Ingestion
Dose activity relation
Fungi
Vertebrata
Mammalia
Animal
Plant origin
Fungi Imperfecti
Teratogen
Fusarium moniliforme
Hamster
Thallophyta
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Summary:The purpose of this study was to characterize the developmental toxicity of fumonisin B1 (FB1), a mycotoxin produced by Fusarium moniliforme, on fetal Syrian hamsters. Fusarium moniliforme has been associated with a variety of diseases in animals and esophageal cancer in humans. Purified FB1 causes leukoencephalomalacia in horses and is hepatocarcinogenic in rats. Fumonisin B1 has been associated with fetal toxicity in rats and mice and has been suggested to be involved in reproductive failure in pregnant sows. Results from a preliminary developmental toxicity study using an aqueous extract of F. moniliforme corn‐culture material in hamsters suggested that FB1 was a developmental toxicant. These results were verified using purified FB1. Six groups of ten time‐mated female Syrian hamsters were dosed with 0.0–18 mg kg−1 day−1 of FB1 by gavage on days 8–12 of gestation and euthanized on day 15. Live fetuses were weighed and examined for gross external and internal abnormalities and skeletal anomalies. Purified fumonisin B1 was shown to cause dose‐dependent fetal death and delayed fetal development without causing fetal abnormalities. © 1998 John Wiley & Sons, Ltd.
Bibliography:istex:29A7FCE8A54864B776BFE3C7EBB01BFE92F1F945
ArticleID:JAT497
ark:/67375/WNG-3GR878R9-S
DHHS - No. RR07004
ISSN:0260-437X
1099-1263
DOI:10.1002/(SICI)1099-1263(199805/06)18:3<197::AID-JAT497>3.0.CO;2-R